Health - Determining the effect of Salmonella infection on longlived intestinal macrophages and identifying their role in preventing IBD
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Biological Sciences
Abstract
Salmonella is a globally significant intestinal infection, causing an estimated 93.8 million cases of gastroenteritis per year. Although usually a self-limiting disease, Salmonella infection can result in increased risk of inflammatory bowel disease (IBD) and colon cancer. The reasons for these post-infection problems are not fully known and further understanding may lead to the development of restorative therapies to prevent these adverse outcomes. Macrophages are known to play a critical role in maintaining gastrointestinal health, contributing to maintaining mucosal barrier integrity and controlling inflammation at this site; dysregulation of these functions are also linked to IBD and colon cancer.
Organisations
People |
ORCID iD |
Tovah Shaw (Primary Supervisor) | http://orcid.org/0000-0002-8107-2836 |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/T00875X/1 | 30/09/2020 | 29/09/2028 | |||
2672580 | Studentship | BB/T00875X/1 | 30/09/2021 | 30/11/2025 |