Rapid Functional and Mechanical Characterisation of Neutrophil-Bacteria Interactions

Lead Research Organisation: Durham University
Department Name: Chemistry

Abstract

Neutrophils are white blood cell that rapidly identify, ingest and kill bacteria However, little is known about the immediate physical processes occurring when neutrophils first meet bacteria, and how these vary in health and during severe infection. This project will address this gap by combining expertise and simultaneously imaging real-time bacterial ingestion, probing changes in neutrophil mechanics, and studying chemical changes in neutrophils. The research will visualise bacterial ingestion, probe the neutrophil's mechanical properties, and link these to functional changes in neutrophils from healthy people and patients. Abnormalities detected will be exploited for new therapeutic treatments.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S022791/1 30/04/2019 30/10/2027
2744004 Studentship EP/S022791/1 30/09/2022 29/09/2026 Siwenyue Marriott Zhang