5a-Reductases: Mapping pathways of Metabolic Disease

Lead Research Organisation: University of Edinburgh
Department Name: College of Medicine & Vet Medicine


5-alpha reductase inhibitors reduce the symptoms of benign prostate hyperplasia but also the breakdown of glucocorticoid in liver. Excess glucocorticoids are well recognised to induce metabolic and cardiovascular diseases. This project aims to investigate the link between 5-alpha reductase and progression of cardiometabolic diseases through (1) the investigation of electronic health datasets, including THINS, SCI-DC, and NHIRD (Taiwan), and (2) SNP and eQTL studies to construct the downstream regulatory networks of 5-alpha reductase.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/W006804/1 30/09/2022 29/09/2028
2746668 Studentship MR/W006804/1 31/08/2022 30/08/2026 Haolan Tu