Inhibiting bacterial cell division by controlling the essential FtsZ/SepH protein-protein interaction
Lead Research Organisation:
University of East Anglia
Department Name: Pharmacy
Abstract
Antibiotic-resistant pathogens are a huge threat in healthcare. The last resorts of conventional antibiotic drugs are unable to treat multi-resistant strains in patients. New approaches towards antibiotics are desperately needed. To spread and survive, bacteria need to divide. Thus, bacterial cell division has emerged as a promising antibiotic target pathway to combat multi-resistant pathogens. This project aims to target a protein-protein interactions that pathogenic bacteria, like the causative agent of TB, Mycobacterium tuberculosis require to propagate. Using Mycobacteria smegmatis as a harmless model organisms for M. tuberculosis, the project will design, synthesise and test compounds which specifically prevent the formation of this essential protein-protein interaction to inhibit cell division.
Organisations
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/T008717/1 | 01/10/2020 | 30/09/2028 | |||
2869043 | Studentship | BB/T008717/1 | 01/10/2023 | 30/09/2027 |