High throughput genetics to enhance long-term efficacy and function of CAR-T cell therapy in solid cancers
Lead Research Organisation:
University of Cambridge
Department Name: Pathology
Abstract
Chimeric antigen receptor (CAR) T cell therapy involves genetically engineering T cells to express CAR which redirect their specificity to target tumour-expressed antigens. While CAR-T cell therapies have led to remarkable clinical responses in haematological malignancies the response in solid cancers has so far been limited.
The aim of this project is to use high-throughput functional screens to identify genetic means of improving solid cancer CAR-T cell efficacy by (a) preventing CAR-T dysfunction and (b) armouring CAR-T cells to overcome immune suppression within the solid tumour microenvironment.
The aim of this project is to use high-throughput functional screens to identify genetic means of improving solid cancer CAR-T cell efficacy by (a) preventing CAR-T dysfunction and (b) armouring CAR-T cells to overcome immune suppression within the solid tumour microenvironment.
People |
ORCID iD |
Rahul Roychoudhuri (Primary Supervisor) | |
Teresa Von Linde (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/W006650/1 | 01/10/2022 | 30/09/2028 | |||
2895113 | Studentship | MR/W006650/1 | 01/10/2023 | 30/09/2027 | Teresa Von Linde |