Development of high-value chemicals bioproduction integrating metabolic engineering, Design of Experiments and entrepreneurship

Lead Research Organisation: Imperial College London
Department Name: Life Sciences

Abstract

The use of genetically engineered strains to biomanufacture chemicals enables direct CO2-to-
product systems with vastly superior environmental sustainability (reduced GHGe) and synthesis
of isomer(s) with a purity not achieved by traditional chemistry. However, the engineering and
optimization of microbial bioproduction strains (essential components in the development of
biological manufacturing systems) is time-consuming and costly. Coupled with the uncertainty of
biological engineering, this leads to higher risk and a lower appetite for investment, making
commercialisation challenging. To enable SynBio to make a meaningful contribution to the
enormous fossil fuel problem, we propose to first commence with higher value beachhead target
products and solve current bottlenecks to developing viable solutions.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S022856/1 01/04/2019 30/09/2027
2898855 Studentship EP/S022856/1 01/10/2023 30/09/2027 Celine Caraffa