Enhancing Mitophagy to treat Parkinson's disease
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Neurosciences
Abstract
Mitochondrial mutations accumulate in Ageing. Evidence suggests mitochondrial mutations arise more frequently in
dopaminergic neurons (DNs) implicated in PD and Prof. Chinnery's Lab has evidence limited mitophagy occurs in
healthy DNs. One hypothesis is DNs conserve their mitochondrial numbers, and deliberately reduce mitophagy. This is
supported by the presence of deubiquitinases like USP30, which remove ubiquitin tags on mitochondria and suppress
parkin-driven mitophagy.
dopaminergic neurons (DNs) implicated in PD and Prof. Chinnery's Lab has evidence limited mitophagy occurs in
healthy DNs. One hypothesis is DNs conserve their mitochondrial numbers, and deliberately reduce mitophagy. This is
supported by the presence of deubiquitinases like USP30, which remove ubiquitin tags on mitochondria and suppress
parkin-driven mitophagy.
People |
ORCID iD |
| Patrick Chinnery (Primary Supervisor) | |
| Brandon Lockey (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/W006650/1 | 30/09/2022 | 29/09/2028 | |||
| 2905842 | Studentship | MR/W006650/1 | 30/09/2022 | 29/09/2026 | Brandon Lockey |