Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Impact Summary
working in the field of bacterial flagella biogenesis.
Engagement Activities
the cilium in chondrocyte mechanotransduction
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Collaboration
Analysis of primary cilia in human cells
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Collaboration
Functional Conservation in Ciliary Trafficking
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Engagement Activities
the University of Southampton
Engagement Activities
Talk
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Engagement Activities
Mucociliary Interactions
Collaboration
PCD male fertility assessment
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
cilia to be resorbed and identified the pathway responsible
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Engagement Activities
flagella - Talk
Collaboration
Developing calcium sensors in green algae
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
Collaboration with molecular basis of disease and therapeutics
Research Databases and Models
This is a collection of Matlab programming functions, that between them, can track the two flagella...
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
UK Cilia Network
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Engagement Activities
Flagella.
Engagement Activities
Flagella.
Engagement Activities
Network Meeting
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Research Tools and Methods
We have used techniques like protein structure prediction with mutation, cloning, and bacterial...
Intellectual Property
Immunogenic compositions containing Escherichia coli O157:H7 flagella including fusion proteins and...
Engagement Activities
Takeover 3 - Fraser McPhie, PhD Student
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Engagement Activities
Talk - DAMTP Fluid Seminars
Engagement Activities
variable length - Talk
Collaboration
Role of primary cilia in cortical development
Engagement Activities
Takeover 2 - Dr Daniel Dodd,
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Engagement Activities
meeting Edinburgh 06/10/2024
Engagement Activities
meeting Edinburgh 06/10/2024
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Collaboration
Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Engagement Activities
years on - at EMBO Cilia 2022 in Cologne, Germany (4th October 2022)
Engagement Activities
variable length - Talk - BAM Colloquium