Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Engagement Activities
the cilium in chondrocyte mechanotransduction
Key Findings
in TALPID3 lack primary cilia, a small organelle found on the surface of each cell.
As primary...
Research Databases and Models
Developed mathematical model for cilia-driven flow near a rigid substrate in a (linear)...
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
PCD male fertility assessment
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Engagement Activities
Talk
Intellectual Property
A tactile sensor, consisting of a flexible main body with embedded magnets, soft magnetized cilia...
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
first was to see IF we could see tiny organelles called primary cilia in the mouse growth plate and...
Engagement Activities
the University of Southampton
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Key Findings
critical for cilia formation functions mechanistically, what lipid preferences it has, and at what...
Research Databases and Models
This is a collection of Matlab programming functions, that between them, can track the two flagella...
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Engagement Activities
Mucociliary Interactions
Engagement Activities
flagella - Talk
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Collaboration
Collaboration with molecular basis of disease and therapeutics
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
Developing calcium sensors in green algae
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Research Tools and Methods
We have used techniques like protein structure prediction with mutation, cloning, and bacterial...
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Key Findings
cilia to be resorbed and identified the pathway responsible
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
Role of primary cilia in cortical development
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Collaboration
UK Cilia Network
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Engagement Activities
Network Meeting
Engagement Activities
Talk - DAMTP Fluid Seminars
Engagement Activities
variable length - Talk
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Collaboration
Collaboration between the University of Warwick and RIKEN
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Research Databases and Models
Computed flow from Stokes singularities in a two layer system
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Key Findings
sensory cilia that sense flow stimuli, not only the type of flow (whether fast vibrations or flow...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Engagement Activities
meeting Edinburgh 06/10/2024
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Engagement Activities
variable length - Talk - BAM Colloquium
Collaboration
Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and...
Engagement Activities
years on - at EMBO Cilia 2022 in Cologne, Germany (4th October 2022)
Research Databases and Models
Paranasal sinuses are hollow spaces within the bones surrounding the nose. Of these, the largest...
Collaboration
Frankfurt/Cologne clinical genetics