Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Impact Summary
working in the field of bacterial flagella biogenesis.
Engagement Activities
the cilium in chondrocyte mechanotransduction
Key Findings
in TALPID3 lack primary cilia, a small organelle found on the surface of each cell.
As primary...
Research Databases and Models
Developed mathematical model for cilia-driven flow near a rigid substrate in a (linear)...
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Collaboration
Analysis of primary cilia in human cells
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
Functional Conservation in Ciliary Trafficking
Engagement Activities
Talk
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Engagement Activities
the University of Southampton
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Engagement Activities
flagella - Talk
Collaboration
PCD male fertility assessment
Engagement Activities
Mucociliary Interactions
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Research Databases and Models
This is a collection of Matlab programming functions, that between them, can track the two flagella...
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Key Findings
cilia to be resorbed and identified the pathway responsible
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Engagement Activities
conference by Hannah Mitchison
Engagement Activities
Hannah Mitchison
Collaboration
Developing calcium sensors in green algae
Collaboration
Collaboration with molecular basis of disease and therapeutics
Research Tools and Methods
We have used techniques like protein structure prediction with mutation, cloning, and bacterial...
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
UK Cilia Network
Engagement Activities
Talk - DAMTP Fluid Seminars
Engagement Activities
variable length - Talk
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Engagement Activities
Network Meeting
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
sensory cilia that sense flow stimuli, not only the type of flow (whether fast vibrations or flow...
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Engagement Activities
Takeover 3 - Fraser McPhie, PhD Student
Research Databases and Models
Computed flow from Stokes singularities in a two layer system
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Collaboration
Role of primary cilia in cortical development
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
Takeover 2 - Dr Daniel Dodd,
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Engagement Activities
meeting Edinburgh 06/10/2024
Engagement Activities
meeting Edinburgh 06/10/2024
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.