Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Engagement Activities
the cilium in chondrocyte mechanotransduction
Impact Summary
working in the field of bacterial flagella biogenesis.
Collaboration
Analysis of primary cilia in human cells
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Collaboration
Functional Conservation in Ciliary Trafficking
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Engagement Activities
the University of Southampton
Engagement Activities
Talk
Collaboration
PCD male fertility assessment
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
Mucociliary Interactions
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
Collaboration with molecular basis of disease and therapeutics
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Engagement Activities
flagella - Talk
Key Findings
cilia to be resorbed and identified the pathway responsible
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
UK Cilia Network
Collaboration
Developing calcium sensors in green algae
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Engagement Activities
Takeover 3 - Fraser McPhie, PhD Student
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Research Databases and Models
This is a collection of Matlab programming functions, that between them, can track the two flagella...
Engagement Activities
variable length - Talk
Engagement Activities
Talk - DAMTP Fluid Seminars
Intellectual Property
Immunogenic compositions containing Escherichia coli O157:H7 flagella including fusion proteins and...
Collaboration
Role of primary cilia in cortical development
Engagement Activities
Takeover 2 - Dr Daniel Dodd,
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
years on - at EMBO Cilia 2022 in Cologne, Germany (4th October 2022)
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Engagement Activities
variable length - Talk - BAM Colloquium
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Collaboration
Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and...
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Primary cilia in Joubert Syndrome
Collaboration
Nordic Centrosome and Cilia Network
Key Findings
understanding the substrate that YhaO transported (ie D serine) and correlating this with the...
Key Findings
range of cellular and developmental processes and defects in IFT underlie a range of pathological...
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Key Findings
how mechanical interactions with polymer networks in biological fluids influence the movement of...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Engagement Activities
Trinity Centre for Bioengineering
Research Tools and Methods
We have developed and refined a procedure to attach superparamagnetic beads (1 micron in diameter)...
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Key Findings
mechanisms that underlie the workings of multicellular organisms, suggesting scenarios by which...