Core Capability - University of York
Lead Research Organisation:
University of York
Department Name: Chemistry
Abstract
The Chemistry Department in York is one of University's largest research-led departments, with approximately 50 academic staff, 57-research fellows, 136 PhD (30 funded by EPSRC, 12 by NERC), and 14 MSc/MRes research students. Our chemical analyses are critical for the publication of research articles and these are made at a number of leading research centres for example, the York Centre of Excellence in Mass Spectrometry (CoEMS), York Centre for Magnetic Resonance (YCMR), York JEOL Nanocentre, and the Centre for Hyperpolarisation in Magnetic Resonance (CHyM). This bid is made for new/replacement equipment to support our leading research in the following activities:
NMR Spectroscopy: We seek funding for a 400 MHz solid state NMR system as a vital extension to our research activities, given the huge importance of solid/soft matter in numerous research and technological areas such as heterogeneous catalysis, green chemistry, materials and nano-science. In addition, we will contribute to solid state NMR methodology research, which will allow our hyperpolarization research to include NMR studies of surface species/catalysis, and also to the expansion of unconventional computational research (based on spin dynamics) that will be extended to much more complicated, time-dependent phenomena than is currently possible.
Mass Spectrometry: In collaboration with Bruker Daltonics, the Centre of Excellence in Mass Spectrometry (CoEMS) in York was supplied with a unique combination and breadth of instrumentation, the centre piece of which is our FT-ICR instrument, which was upgraded to the new solariX. FT-ICR is the method that provides the highest resolution and accuracy measurements in mass spectrometry. The specification of our current instrument (9.4T solariX) has a resolution of 1.5 x 10 sixth at m/z 400. With its MALDI and ESI sources, it is also capable of imaging MS. We now seek to upgrade the solariX to the even higher resolving power and accuracy required to capture the full range of information for increasingly complex natural mixtures like fossil- and bio-fuels and many other current analytical challenges such as the molecular-level characterization of atmospheric aerosols and probing intact proteins and protein assemblies.
Small Angle X-Ray Diffraction: "Soft-matter" comprises a family of differing materials from membrane lipids, detergents, polymers, and nanoparticles to liquid crystals; ie, systems integral to every-day-life. The properties and applications of such systems require detailed understanding of structure and local molecular organisation. Previously, structures were inferred from polarized light microscopy, however, as the complexities of the phases of functional materials increase modern X-ray diffraction has become the standard for structural characterisation. This request is directed at extending our cutting edge research on self-assembling systems, via the acquisition of a diffractometer with custom-made sample holders, to study phase structures in the bulk, in thin films, and in devices.
Fluorescence X-ray Spectroscopy: In 2009, UoY prioritised the purchase of a micro-X-ray fluorescence (Horiba XGT-7000 Micro XRF). The instrument provides non-destructive elemental analysis, beyond CHN (ppm levels), directly from the sample (solid or liquid) without digestion using hazardous strong acids (ie, mandatory for flame atomic absorption). The equipment is currently unusable and needs parts replacing and repair.
NMR Spectroscopy: We seek funding for a 400 MHz solid state NMR system as a vital extension to our research activities, given the huge importance of solid/soft matter in numerous research and technological areas such as heterogeneous catalysis, green chemistry, materials and nano-science. In addition, we will contribute to solid state NMR methodology research, which will allow our hyperpolarization research to include NMR studies of surface species/catalysis, and also to the expansion of unconventional computational research (based on spin dynamics) that will be extended to much more complicated, time-dependent phenomena than is currently possible.
Mass Spectrometry: In collaboration with Bruker Daltonics, the Centre of Excellence in Mass Spectrometry (CoEMS) in York was supplied with a unique combination and breadth of instrumentation, the centre piece of which is our FT-ICR instrument, which was upgraded to the new solariX. FT-ICR is the method that provides the highest resolution and accuracy measurements in mass spectrometry. The specification of our current instrument (9.4T solariX) has a resolution of 1.5 x 10 sixth at m/z 400. With its MALDI and ESI sources, it is also capable of imaging MS. We now seek to upgrade the solariX to the even higher resolving power and accuracy required to capture the full range of information for increasingly complex natural mixtures like fossil- and bio-fuels and many other current analytical challenges such as the molecular-level characterization of atmospheric aerosols and probing intact proteins and protein assemblies.
Small Angle X-Ray Diffraction: "Soft-matter" comprises a family of differing materials from membrane lipids, detergents, polymers, and nanoparticles to liquid crystals; ie, systems integral to every-day-life. The properties and applications of such systems require detailed understanding of structure and local molecular organisation. Previously, structures were inferred from polarized light microscopy, however, as the complexities of the phases of functional materials increase modern X-ray diffraction has become the standard for structural characterisation. This request is directed at extending our cutting edge research on self-assembling systems, via the acquisition of a diffractometer with custom-made sample holders, to study phase structures in the bulk, in thin films, and in devices.
Fluorescence X-ray Spectroscopy: In 2009, UoY prioritised the purchase of a micro-X-ray fluorescence (Horiba XGT-7000 Micro XRF). The instrument provides non-destructive elemental analysis, beyond CHN (ppm levels), directly from the sample (solid or liquid) without digestion using hazardous strong acids (ie, mandatory for flame atomic absorption). The equipment is currently unusable and needs parts replacing and repair.
Planned Impact
The University of York's proposal is based on a collective approach by the N8 universities to the EPSRC Core Capability Call. This approach is in response to the Wakeham Review of efficiencies in research funding, a report was commissioned in 2011 to explore the benefits of wider collaboration across the universities represented by the group (Prof L. Georghiou, Sharing for Excellence and Growth, 2011, http://www.n8research.org.uk/research_areas/). This report identified a strong need of the N8 group to collaborate and co-ordinate on equipment and capital costs, where this is viable. The coordinated bid from the N8 Universities is in full alignment with this recommendation.
An asset-sharing programme has been developed to create an integrated database of assets that are available for the use of researchers throughout the N8. These systems describe the research equipment in detail, including its availability, procedures for access (eg health and safety and training) and how access would be charged to another institution. Through the implementation and utilisation of this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution. Furthermore, as a result the N8 Collective will be able to continue to train chemists to a standard in order to enable them to compete on national and international levels on the most relevant equipment.
An asset-sharing programme has been developed to create an integrated database of assets that are available for the use of researchers throughout the N8. These systems describe the research equipment in detail, including its availability, procedures for access (eg health and safety and training) and how access would be charged to another institution. Through the implementation and utilisation of this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution. Furthermore, as a result the N8 Collective will be able to continue to train chemists to a standard in order to enable them to compete on national and international levels on the most relevant equipment.
Organisations
Publications
Liang J
(2019)
A subcompatible rhizobium strain reveals infection duality in Lotus.
in Journal of experimental botany
Lia A
(2020)
Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid.
in Wellcome open research
Lia A
(2020)
Partial catalytic Cys oxidation of human GAPDH
in Wellcome Open Research
Li Z
(2024)
Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity-Based Probes
in Angewandte Chemie International Edition
Leadbeater DR
(2021)
Mechanistic strategies of microbial communities regulating lignocellulose deconstruction in a UK salt marsh.
in Microbiome
Lau C
(2023)
A phase-separated CO2-fixing pyrenoid proteome determined by TurboID in Chlamydomonas reinhardtii
in The Plant Cell
Krajcarz M
(2025)
Dietary preferences and collagen to collagen prey-predator trophic discrimination factors ( ? 13 C, ? 15 N) in late Pleistocene cave hyena
in Quaternary Research
Keenan T
(2021)
A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein a-oxo-Aldehydes in Competing a-oxo-Mannich and Catalyst-Free Aldol Ligations
in ACS Chemical Biology
Keenan T
(2024)
Structural dissection of the CMP-pseudaminic acid synthetase, PseF.
in Structure (London, England : 1993)
Keenan T
(2023)
Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manß1,4GlcNAc library.
in Chemical science
Keenan T
(2020)
Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides.
in Cell chemical biology
High K
(2019)
New approaches using mass spectrometry to investigate changes to cytokinin and abscisic acid (ABA) concentrations in soil
in Soil Biology and Biochemistry
Hennius A
(2022)
Late Iron Age Whaling in Scandinavia
in Journal of Maritime Archaeology
Hendi NN
(2024)
Functional characterization of the SDR42E1 reveals its role in vitamin D biosynthesis.
in Heliyon
Helena-Bueno K
(2024)
A new family of bacterial ribosome hibernation factors.
in Nature
Hauser JR
(2021)
Pyrene Tags for the Detection of Carbohydrates by Label-Assisted Laser Desorption/Ionisation Mass Spectrometry*.
in Chembiochem : a European journal of chemical biology
Hatton N
(2024)
Synthesis of colicin Ia neoglycoproteins: tools towards glyco-engineering of bacterial cell surfaces
in RSC Advances
Hann JL
(2019)
Pentaerythritol Derived Tetrapode Exhibiting a Nematic-Like Mesophase at Ambient Temperatures.
in Chemphyschem : a European journal of chemical physics and physical chemistry
Goodby J
(2019)
Nano-objects - sculpting and shape in molecular material design (The Pierre Gilles de Gennes ILCS prize lecture)
in Liquid Crystals
Goodby J
(2017)
Free volume, molecular grains, self-organisation, and anisotropic entropy: machining materials
in Liquid Crystals
Goodby J
(2021)
Janus mesophases of matter
in Liquid Crystals
Geoghegan V
(2022)
CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics.
in Communications biology
Gao H
(2020)
Application of serine integrases for secondary metabolite pathway assembly in Streptomyces.
in Synthetic and systems biotechnology
Gaffney I
(2021)
Metabolomic Approaches to Studying the Response to Drought Stress in Corn (Zea mays) Cobs.
in Metabolites
Fritsch L
(2021)
Carbosilane terminated alkoxycyanobiphenyls for bistable scattering mode LCDs
in Journal of Materials Chemistry C
Forestier E
(2021)
Engineering Production of a Novel Diterpene Synthase Precursor in Nicotiana benthamiana
in Frontiers in Plant Science
Fisher P
(2019)
Modeling Glycan Processing Reveals Golgi-Enzyme Homeostasis upon Trafficking Defects and Cellular Differentiation.
in Cell reports
Fisher P
(2019)
The N-Glycosylation Processing Potential of the Mammalian Golgi Apparatus.
in Frontiers in cell and developmental biology
Ferreira TR
(2020)
PRMT7 regulates RNA-binding capacity and protein stability in Leishmania parasites.
in Nucleic acids research
Evans M
(2023)
Detection of dairy products from multiple taxa in Late Neolithic pottery from Poland: an integrated biomolecular approach.
in Royal Society open science
Ebanks B
(2022)
Proteomic analysis of the ATP synthase interactome in notothenioids highlights a pathway that inhibits ceruloplasmin production.
in American journal of physiology. Regulatory, integrative and comparative physiology
Drieu L
(2020)
Is it possible to identify ancient wine production using biomolecular approaches?
in STAR: Science & Technology of Archaeological Research
Drieu L
(2024)
A medium-throughput approach for improved taxonomic identification of lipids preserved in ancient pottery
in Archaeometry
Ding R
(2022)
Experimental and numerical study on motion instability of modular floating structures
in Nonlinear Dynamics
Digomann D
(2019)
The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity
in Clinical Cancer Research
Dierickx K
(2022)
Peptide mass fingerprinting of preserved collagen in archaeological fish bones for the identification of flatfish in European waters.
in Royal Society open science
Dierickx K
(2023)
Rapid collagen peptide mass fingerprinting as a tool to authenticate Pleuronectiformes in the food industry
in Food Control
Dekker J
(2023)
Spatial analysis of the ancient proteome of archeological teeth using mass spectrometry imaging.
in Rapid communications in mass spectrometry : RCM
De Pablos LM
(2019)
The mRNA-bound Proteome of Leishmania mexicana: Novel Genetic Insight into an Ancient Parasite.
in Molecular & cellular proteomics : MCP
Cracknell T
(2020)
Proteomic resolution of IGFN1 complexes reveals a functional interaction with the actin nucleating protein COBL
in Experimental Cell Research
Chidwick HS
(2021)
Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac.
in Scientific reports
Chauhan N
(2024)
Contrasting species-specific stress response to environmental pH determines the fate of coccolithophores in future oceans.
in Marine pollution bulletin
| Description | This grant was to upgrade the equipment base in the department. This has been achieved. |
| Exploitation Route | The new equipment is in constant use and underpins many current scientific investigations |
| Sectors | Agriculture Food and Drink Chemicals Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | This award was to upgrade key departmental equipment. |
| First Year Of Impact | 2013 |
| Sector | Agriculture, Food and Drink,Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |