Selection for antibiotic resistance in complex microbial communities
Lead Research Organisation:
UNIVERSITY OF EXETER
Department Name: University of Exeter Medical School
Abstract
It is becoming increasingly clear that the natural environment plays an important role in the evolution and dissemination of antibiotic resistance. This studentship will determine the mechanistic basis and significance of gene flow that underlies the abundance of antimicrobial resistance genes in bacteria inhabiting polluted natural environments such as downstream of waste water treatment plants (WWTPs). It is unclear whether increased prevalence of antibiotic resistant organisms associated with WWTPs is due to constant emissions of resistant organisms or whether bacteria such as multi-drug resistant E. coli persist and/or acquire resistance genes by horizontal gene transfer (HGT) in aquatic sediments under selection by environmental pollutants including antibiotic residues. This project will study selection for resistance in complex communities utilising mesocosm studies interrogated using culture and culture independent methods. The latter will include real-time PCR for enumeration of key marker genes and next generation sequencing (NGS) to determine the effects of single antibiotics, mixtures of different classes of antibiotic and field samples of polluted effluents on relative abundance of all known resistance genes. This knowledge will be used to support environmental policy development and environmental risk management.
People |
ORCID iD |
William Gaze (Primary Supervisor) | |
Isobel Stanton (Student) |
Publications
Gaze W.H.
(2017)
Antimicrobial Resistance: Investigating the Environmental Dimension.
Gaze, W.H.
(2017)
Have we opened the floodgates on antimicrobial resistance?
Grenni P
(2019)
Sulfamethoxazole persistence in a river water ecosystem and its effects on the natural microbial community and Lemna minor plant
in Microchemical Journal
Murray AK
(2020)
The 'SELection End points in Communities of bacTeria' (SELECT) Method: A Novel Experimental Assay to Facilitate Risk Assessment of Selection for Antimicrobial Resistance in the Environment.
in Environmental health perspectives
Murray AK
(2021)
Dawning of a new ERA: Environmental Risk Assessment of antibiotics and their potential to select for antimicrobial resistance.
in Water research
Powell N
(2017)
Developing a local antimicrobial resistance action plan: the Cornwall One Health Antimicrobial Resistance Group.
in The Journal of antimicrobial chemotherapy
Rauseo J
(2019)
Dissipation of the antibiotic sulfamethoxazole in a soil amended with anaerobically digested cattle manure.
in Journal of hazardous materials
Stanton I.
(2020)
Selection for antibiotic resistance in complex microbial communities
Stanton IC
(2020)
Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration.
in Communications biology
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/N504026/1 | 30/09/2015 | 29/09/2019 | |||
1641426 | Studentship | BB/N504026/1 | 30/09/2015 | 29/09/2019 | Isobel Stanton |
Description | Measureable concentrations of antibiotics are released into the environment from anthropogenic sources. Environmental risk assessment investigates the risks these concentrations pose to aquatic life but does not determine whether selection for resistance is occurring. Recent studies suggest environmental concentrations of tetracycline, ciprofloxacin and cefotaxime may be able to select for resistance in complex microbial communities. The aims of research were to determine whether selection for resistance occurs at environmentally relevant concentrations of macrolide antibiotics; to understand how mixtures of antibiotics affect selective endpoints; to understand the effect of temperature on selective endpoints, and, finally, to compare the methods used with previously published methods. Selective endpoints of macrolide antibiotics were found to be 750 µg/L for azithromycin, clarithromycin and erythromcyin which is significantly higher than current environmental concentrations. Mixing of antibiotics produces at least an additive, if not a synergistic, effect. The selective endpoints of sulfamethoxazole and trimethoprim decrease over 11 times and by a half, respectively, when used in combination. The selective endpoint of macrolides is reduced by a third when they are found in combination. Selective endpoints of individual genes are affected by temperature but, as only preliminary data has been produced, overall effect concentrations have not been determined across the entire experimental resistome. Alternative gene targets associated with taxa favoured at low temperatures may be under selection. Finally, the phenomenon of increased persistence has been described and the minimal increased persistence concentration has been defined for the first time. |
Exploitation Route | Data can be used by policy makers in environmental risk assessments, in conjunction with other ecotoxicological endpoints to determine safe release levels of antibiotic residues in wastewater. This will help minimise selection for antibiotic resistance in the environment and, therefore, exposure of humans to resistant bacteria through environmental transmission. Unpublished data (the selective endpoints of the macrolide antibiotics and the mixing effect observed when combining trimethoprim and sulfamethoxazole) was shared with the European Environment Agency's Joint Research Council for consideration when developing the next Water Framework Directive's priority watch list. This has resulted in two antibiotics that was not previously on the list being put forward for inclusion on the watch list based on data shared. |
Sectors | Environment Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
Description | Unpublished data was shared with the European Environment Agency's Joint Research Council for consideration when developing the next Water Framework Directive's priority watch list. This has resulted in two antibiotics that was not previously on the list being put forward for inclusion on the watch list based on data shared. Two antibiotics have now been included and three removed. https://circabc.europa.eu/faces/jsp/extension/wai/navigation/container.jsp |
First Year Of Impact | 2020 |
Sector | Environment |
Impact Types | Policy & public services |
Description | ? Invited to meeting in South America (Argentina or Uruguay in June 2018) to advise the Interagency Coordination Group on Antimicrobial Resistance (IACG) co-chaired by the UN Deputy Secretary-General and the Director General of the World Health Organization. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Contribution to a national consultation/review |
Description | Co-authored a box in Chief Medical Officers annual report |
Geographic Reach | National |
Policy Influence Type | Citation in other policy documents |
URL | https://www.gov.uk/government/publications/chief-medical-officer-annual-report-2017-health-impacts-o... |
Description | EEA forwarded unpublsihed research (submitted) to JRC. As a result they have shortlisted trimethoprim for inclusion on the hazardous compound watch list. |
Geographic Reach | Europe |
Policy Influence Type | Contribution to a national consultation/review |
Impact | The EU Joint Research Centre is considering adding additional antibiotics to the Water Framework Directive's hazardous compound watch list based on our UKRI funded research |
Description | Informed the European Commission Water Framework Directive's Hazardous substances list |
Geographic Reach | Europe |
Policy Influence Type | Contribution to a national consultation/review |
Impact | Stanton 2020, Murray 2020 and Stanton (unpublished) was shared with the European Environment Agency before publication to help inform the next iteration of the watch list. This resulted in the macrolide antibiotics being removed, and trimethoprim and sulfamethoxazole being added. |
URL | https://circabc.europa.eu/faces/jsp/extension/wai/navigation/container.jsp |
Description | Informing decision making around the WFD watch list of antibiotics |
Geographic Reach | Europe |
Policy Influence Type | Citation in other policy documents |
Impact | Research has influenced decision making on inclusion of antibiotics on the WFD hazardous compound watch list |
Description | Invited by Lee Slater (Senior Policy Advisor on AMR in the environment at Defra) to sit on a panel of academic experts in a series of workshops between the US, UK, China and India on antimicrobial resistance and antibiotic pollution in the environment. It's being co-ordinated by the UK Science and Innovation Network and the USA Centers for Disease Control and Prevention. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Contribution to a national consultation/review |
Description | Invited to speak to Defra Antimicrobial Resistance Coordination (DARC) Group Autumn 2017 on AMR in the environment. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a guidance/advisory committee |
Impact | Talk to Defra and veterinary medicines directorate about antibiotics in the environment |
Description | Invited to speak to Defra Hazardous Substances Advisory committee about AMR in the environment |
Geographic Reach | National |
Policy Influence Type | Participation in a guidance/advisory committee |
Description | Presentation to All Party Parliamentary Group meeting |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | Presentation to All Party Parliamentary Group meeting on Antibiotics in the Environment |
URL | https://appg-on-antibiotics.com/assets/Report-APPGMeeting2020-16122020.pdf |
Description | Report for United Nations Env Programme |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Contribution to a national consultation/review |
Impact | Report was published alongside UNEA commitment to tackle AMR form an environment and human health perspective |
Description | Second consultative meeting in preparation of the report on the environment and health impacts of pesticides and fertilizers (UNEP, WHO, FAO). |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Description | Strategies for Addressing Antimicrobial Resistance - Future challenges for UK policy |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Description | Three papers cited in the Download the JPIAMR Strategic Research and Innovation Agenda on Antimicrobial Resistance 2019 |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in other policy documents |
URL | https://www.jpiamr.eu/wp-content/uploads/2019/05/JPIAMR_SRIA_final.pdf |
Description | UNEP Frontiers 2017 report only one of two cited papers/reports on AMR and the environment in Interagency Coordination Group on AMR Final report presented to the UN Secretary general |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in other policy documents |
Impact | This is arguably the most important document on AMR produced by the WHO/FAO/OIE and scientific experts in recent years as it will shape the global response to AMR by the UN/WHO. |
URL | https://www.who.int/antimicrobial-resistance/interagency-coordination-group/en/ |
Description | Mapping the evidence for the risks of human exposure and transmission of AMR in the natural environment |
Amount | £80,590 (GBP) |
Funding ID | NE/S015965/1 |
Organisation | Natural Environment Research Council |
Sector | Public |
Country | United Kingdom |
Start | 01/2019 |
End | 09/2020 |
Description | Microbiology Society Annual Conference Grant |
Amount | £300 (GBP) |
Organisation | Microbiology Society |
Sector | Learned Society |
Country | United Kingdom |
Start | 03/2017 |
End | 04/2017 |
Description | Microbiology Society Travel Grant |
Amount | £254 (GBP) |
Organisation | Microbiology Society |
Sector | Learned Society |
Country | United Kingdom |
Start | 09/2018 |
End | 10/2018 |
Description | The environmental dimension of antimicrobial resistance: informing policy, regulation and practice. |
Amount | £72,525 (GBP) |
Funding ID | NE/S006257/1 |
Organisation | Natural Environment Research Council |
Sector | Public |
Country | United Kingdom |
Start | 01/2019 |
End | 12/2021 |
Description | Towards Developing an International Environmental AMR Surveilance Strategy |
Amount | £44,356 (GBP) |
Funding ID | MR/S037713/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2019 |
End | 12/2020 |
Description | Travel Grant |
Amount | £150 (GBP) |
Organisation | British Society for Antimicrobial Chemotherapy |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2017 |
End | 12/2018 |
Description | Water Research Institute, National Research Council (IRSA-CNR) |
Organisation | National Research Council |
Country | Italy |
Sector | Public |
PI Contribution | We hosted one PhD student from the Water Research Institute, National Research Council (IRSA-CNR) on a summer placement project in 2016 and Isobel Stanton trained her in qPCR analysis. She was able to run analyse a number of samples using qPCR to investigate antibiotic resistance gene prevalence during her time here from her current work. After her summer placement project, samples were sent to us from the Water Research Institute, National Research Council (IRSA-CNR) and Isobel Stanton undertook qPCR analysis on these investigating antibiotic resistance gene prevalence. Two publications that resulted from this, |
Collaborator Contribution | The Water Research Institute, National Research Council (IRSA-CNR) undertook the chemistry and microbiology work for, and wrote the drafts of, the two publications. |
Impact | Two publications have resulted from this collaboration: https://doi.org/10.1016/j.jhazmat.2019.120769 https://doi.org/10.1016/j.microc.2019.103999 This collaboration was multi-disciplinary involving work in chemical analysis, microbiology and molecular biology. |
Start Year | 2017 |
Description | "Behind the paper" blog post - Nature Microbiology Community |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Blog written on request from Nature Microbiology Community by Isobel Stanton, Aimee Murray and William Gaze to summarise key findings of Stanton 2020 Communications Biology: "Do antibiotics excreted by humans and animals drive evolution of resistance in the environment?" |
Year(s) Of Engagement Activity | 2020 |
URL | https://naturemicrobiologycommunity.nature.com/posts/do-antibiotics-excreted-by-humans-and-animals-d... |
Description | ? Attended a Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) workshop in Gothenburg |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Attended a Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) workshop in Gothenburg in September 2017 to explore and identify critical research needs that relate to the environmental dimensions of AMR, both in the longer term for providing input to an updated JPIAMR Strategic Research Agenda, but also in the shorter term to provide guidance for specific calls. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.jpiamr.eu/wp-content/uploads/2017/11/Report-_JPIAMR-workshop-on-Environmental-dimensions... |
Description | ? Gaze WH. The environmental aspects of antibiotic resistance. Learned Societies AMR meeting. June 25th, 2015 London. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Antimicrobial resistance: environments,evolution and transmission Networking workshops for researchers |
Year(s) Of Engagement Activity | 2015 |
URL | https://www.responsibleantibioticuse.org/#xl_xr_page_index |
Description | ? Invited by MRC to work with Viadynamics to develop an AMR framework to map out research challenges and ways in which we are addressing those challenges. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Advise RCUK policy on research priorities on AMR |
Year(s) Of Engagement Activity | 2017 |
Description | ? Invited to EA meeting on AMR in waste water to plan EA programme of investigation. March 2017 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Help inform water industry AMR research programme |
Year(s) Of Engagement Activity | 2017 |
Description | ? NERC Planet Earth article "Have we opened the floodgates on antimicrobial resistance?" Winter 2016/17. |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | ?Article for Planet earth detailing role of flooding and climate change on environmental transmission of Amr |
Year(s) Of Engagement Activity | 2017 |
Description | Al Khaleej Today online article for Murray et al 2020 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Al Khaleej Today online article following University of Exeter press release for Murray et al 2020 (Environmental Health Perspectives) |
Year(s) Of Engagement Activity | 2020 |
URL | https://alkhaleejtoday.co/international/5154624/Scientists-are-paving-the-way-for-reducing-antibioti... |
Description | BSAC conference 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Annual workshop for the British Society for Antimicrobial Chemotherapy. Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2016 |
Description | BSAC conference 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Annual workshop for the British Society for Antimicrobial Chemotherapy. Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2017 |
Description | Blog for British Society for Antimicrobial Chemotherapy |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | British Society for Antimicrobial Chemotherapy blog post: "Antibiotics and antibiotic resistance in our waters - are we up a creek without a paddle?" Written by Aimee Murray, William Gaze, Isobel Stanton and Anne Leonard. Based on Stanton et al 2020, Murray et al 2020 and Leonard et al 2018. |
Year(s) Of Engagement Activity | 2020 |
URL | http://bsac.org.uk/antibiotics-and-antibiotic-resistance-in-our-waters-are-we-up-a-creek-without-a-p... |
Description | Daily Mail Online article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Daily Mail Online article written following press release from University of Exeter Medical School |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.dailymail.co.uk/news/article-8696367/Antiobiotics-waterways-puts-millions-danger-increas... |
Description | EDAR conference 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | International conference for the Environmental Dimension of Antibiotic Resistance. Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2017 |
Description | Guest lecturer |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Undergraduate students |
Results and Impact | Following press release from University of Exeter for Stanton et al 2020 (Communications Biology), Isobel Stanton was asked to give guest lectures at the University of Cambridge's Certificate of Infectious disease course as part of their Institute of Continuing Education. |
Year(s) Of Engagement Activity | 2020,2021 |
Description | HCWH webinar with myself and Dame Sally Davies, I hr to journalists and other specialists eg. WHO. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Webinar with myself and Dame Sally Davies answering questions from policy makers and media around AMR |
Year(s) Of Engagement Activity | 2019 |
Description | ISME conference 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Poster presentation at ISME 17 conference |
Year(s) Of Engagement Activity | 2018 |
Description | ISME16 - Montreal |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | International conference for the International Society of Microbial Ecology. Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2016 |
Description | Interview for BBC Radio 4 Costing the Earth. Swimming in Superbugs episode. |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview for BBC Radio 4 Costing the Earth: Swimming in Superbugs episode. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bbc.co.uk/programmes/m000mr6r |
Description | Interview on Times Radio as a results of Stanton 2020, Communications Biology |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Times Radio interview with Carole Walker - late night headlines (3rd September 2020. 10:20pm). University of Exeter press office version: https://mms.tveyes.com/PlaybackPortal.aspx?SavedEditID=082d859a-1be9-4c9d-88da-878724bebb6c |
Year(s) Of Engagement Activity | 2020 |
Description | Invited to speak at Bolivian conference on AMR attended by the minister of health. Santa Cruz, June 2019. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | I had previously been invited to travel to Bolivia and speak to the AMR Action plan committee hosted by the British Embassy in La Paz, this was a follow up presentation to a similar group including the Minister of Health. |
Year(s) Of Engagement Activity | 2019 |
Description | Keynote speaker at the Environmental Dimension of Antibiotic Resistance conference in Hong Kong in June 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was an international conference attended by academics and representatives from Wellcome, WHO and UNEP. I presented the theoretical framework which underpins this project grant and it was well received with both Wellcome and WHO requesting a copy of my presentation. |
Year(s) Of Engagement Activity | 2019 |
Description | Live24 online article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Live24 news article following press release from University of Exeter for Stanton et al 2020 (Communications Biology) |
Year(s) Of Engagement Activity | 2020 |
URL | https://live24.ru/nauka/34292-uchenye-zajavili-chto-vysokij-uroven-antibiotikov-v-rekah-podvergaet-o... |
Description | MSN online article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | MSN online article following press release from University of Exeter for Stanton et al 2020 (Communications Biology) |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.msn.com/en-gb/health/medical/antibiotics-in-rivers-risks-lives-new-study-reveals/ar-BB18... |
Description | Microbiology Society Annual Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Annual conference for the Microbiology Society. Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2017 |
Description | NERC KE Fellowship working with EA, Defra, Water and pharmaceutical industries |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | This is in its early stages but it has already resulted in a JPIAMR (MRC) funded network on environmental AMR surveillance which has resulted in engagement with gov stakeholders and national / international partners |
Year(s) Of Engagement Activity | 2019 |
Description | Noticiasdelaciencia.com online article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Online article noticiasdelaciencia.com following press release from University of Exeter about Stanton et al 2020 (Communications Biology). |
Year(s) Of Engagement Activity | 2020 |
URL | https://noticiasdelaciencia.com/art/39458/antibioticos-en-las-cloacas-la-amenaza-oculta-de-la-resist... |
Description | Outreach Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Teaching Antibiotic Resistance in the Context of One Health at schools within Cornwall |
Year(s) Of Engagement Activity | 2019 |
Description | Phys.org online article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Online article as a response to University of Exeter press release for Stanton et al 2020 (Communications Biology) |
Year(s) Of Engagement Activity | 2020 |
URL | https://phys.org/news/2020-09-safe-thresholds-antibiotics-sewage-combat.html |
Description | Phys.org online article based on Murray 2020 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Phys.org online article following University of Exeter press release for Murray et al 2020 (Environmental Health Perspectives) |
Year(s) Of Engagement Activity | 2020 |
URL | https://phys.org/news/2020-10-scientists-pave-antibiotic-resistance-build-up.html |
Description | Presentation at the Environmental Dimension of AMR meeting in Hong Kong |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Presentation from EDAR5 (basis for UK:Argentina grant detailing conceptual framework for Environmental AMR) requested by Tim Jinks (Head of Infection at Wellcome) and David Sutherland (WHO Technical Officer One Health Tripartite Coordination Group for Asia and the Pacific). "I'd be very grateful if you could send your presentation. It will be treated in confidence but will help with my briefing to WHO and FAO (duly acknowledged) and modifications to my risk framework". |
Year(s) Of Engagement Activity | 2019 |
Description | Press release for Murray et al 2020 (Environmental Health Perspectives) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Press release from University of Exeter for Murray et al 2020 (Environmental Health Perspectives) |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.exeter.ac.uk/research/news/articles/scientistspavewaytoreduci.html |
Description | Press release for Stanton et al 2020 (Communications Biology) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Press release for Stanton 2020 (Communications Biology) was released by the University of Exeter Medical School. This resulted in media interviews undertaken and news paper articles written about the publication. |
Year(s) Of Engagement Activity | 2020 |
URL | https://medicine.exeter.ac.uk/news/articles/safethresholdsforantibiot.html |
Description | Public Outreach Event - Eden Project. BSAC & Public Health England |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Attended Eden Project to engage both children and parents visiting during half term on the issues of antimicrobial resistance and spread of disease. Children were involved in activities to show the importance of hand washing, the spread of germs when sneezing and basic demonstrations of how antibiotic resistance begins and spreads. Parents were spoken to about antimicrobial resistance and sparked discussions about not using them for viral infections/colds/flu etc and the importance of vaccines. Parents were also encouraged to sign up to become Antibiotic Guardians (Public Health England's Scheme). |
Year(s) Of Engagement Activity | 2016 |
URL | http://antibioticguardian.com/keep-antibiotics-working/ |
Description | SETAC conference 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | International conference for the Society of Environmental Toxicology and Chemistry. Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2016 |
Description | SETAC conference 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | International conference for the Society of Environmental Toxicology and Chemistry. Flash talk and Poster presentation. Discussion with other delegates. |
Year(s) Of Engagement Activity | 2017 |
Description | STEAC conference 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Oral presentation give to between 100-200 delegates at the SETAC Rome conference |
Year(s) Of Engagement Activity | 2018 |
Description | Speaking at House of Commons UKRI AMR research strategy refresh |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Speaking at House of Commons UKRI AMR research strategy refresh focusing on existing UKRI funded work in the area of AMR and the environment |
Year(s) Of Engagement Activity | 2019 |
Description | Times online article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Times print article alongside Radio Interview as a result of the University of Exeter press release for Stanton et al 2020 (Communications Biology) |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.thetimes.co.uk/article/medical-waste-in-rivers-raises-threat-of-antibiotic-resistance-f3... |
Description | XENOWAC II Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Oral presentation given at XENOWAC II conference |
Year(s) Of Engagement Activity | 2018 |