Ca2+ and Viruses: Probing Novel Ca2+ Channels in Viral Entry
Lead Research Organisation:
University College London
Department Name: Structural Molecular Biology
Abstract
Viruses, such as the Ebola virus, that enter cells through late endosomes, have been shown recently to require a novel class of host ion channels known as the two-pore channels (TPCs) for infection. We aim to establish how human TPCs impact on virus entry and investigate whether TPCs might be targeted therapeutically to develop novel specific, or broad-spectrum, anti-virals. This project is of contemporary significance and offers broad training at the interface of cell signalling, membrane traffic, drug discovery and disease.
Organisations
People |
ORCID iD |
Mark Marsh (Primary Supervisor) | |
Kristin Vassileva (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M009513/1 | 30/09/2015 | 31/03/2024 | |||
1764823 | Studentship | BB/M009513/1 | 30/09/2016 | 29/06/2021 | Kristin Vassileva |