Ca2+ and Viruses: Probing Novel Ca2+ Channels in Viral Entry

Lead Research Organisation: University College London
Department Name: Structural Molecular Biology

Abstract

Viruses, such as the Ebola virus, that enter cells through late endosomes, have been shown recently to require a novel class of host ion channels known as the two-pore channels (TPCs) for infection. We aim to establish how human TPCs impact on virus entry and investigate whether TPCs might be targeted therapeutically to develop novel specific, or broad-spectrum, anti-virals. This project is of contemporary significance and offers broad training at the interface of cell signalling, membrane traffic, drug discovery and disease.

Publications

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Patel S (2018) Thinking through acidic Ca stores. in Science signaling

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M009513/1 01/10/2015 30/09/2023
1764823 Studentship BB/M009513/1 26/09/2016 30/03/2021 Kristin Vassileva