Computational modelling of separation processes for green continuous pharmaceutical manufacturing
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Engineering
Abstract
Continuous pharmaceutical manufacturing (CPM) has been shown to provide significant cost savings and reduction of material requirements and waste compared to the currently used, yet inefficient, batch methods. With the highest research and development costs of all industrial sectors, and historically increasing commercialisation costs, technological innovation is essential for pharmaceutical firms to remain profitable and sustainable. For the benefits of CPM to be realised by industry, demonstration of its feasibility and viability is paramount. The proposed PhD project looks to focus on the environmental benefits of CPM by process modelling and simulation of drug purification and separation stages. Non-linear programming of separation processes using rigorous thermodynamic modelling will be implemented to provide insights into the best separation process options. This will showcase the green benefits of CPM over the current batch paradigm, and contribute work to further the switch from batch to continuous manufacturing in the pharmaceutical industry today.
Organisations
People |
ORCID iD |
| Dimitrios Gerogiorgis (Primary Supervisor) | |
| Samir Diab (Student) |
Publications
Diab S
(2020)
Design Space Identification and Visualization for Continuous Pharmaceutical Manufacturing.
in Pharmaceutics
Diab S.
(2019)
Process modelling, design and technoeconomic liquid-liquid extraction (LLE) optimisation for comparative evaluation of batch vs. continuous pharmaceutical manufacturing of atropine
in Computers & Chemical Engineering
Diab S.
(2017)
Technoeconomic Evaluation of Multiple Mixed Suspension-Mixed Product Removal (MSMPR) Crystallizer Configurations for Continuous Cyclosporine Crystallization
in Organic Process Research & Development
Diab S.
(2018)
Technoeconomic optimization of continuous crystallization for three active pharmaceutical ingredients, (APIs): cyclosporine, paracetamol and aliskiren
in Industrial & Engineering Chemistry Research
Diab S.
(2017)
Process modelling, simulation and technoeconomic evaluation of separation solvents for the continuous pharmaceutical manufacturing (CPM) of diphenhydramine
in Organic Process Research & Development
Diab S.
(2019)
Process Design and Optimization for the Continuous Manufacturing of Nevirapine, an Active Pharmaceutical Ingredient for HIV Treatment
in Organic Process Research & Development
Diab S.
(2018)
Process Systems Engineering for Pharmaceutical Manufacturing
Ellerker M.E.
(2018)
28th European Symposium on Computer Aided Process Engineering
Jolliffe, H.G.
(2018)
Nonlinear optimization via explicit NRTL model solubility prediction for antisolvent mixture selection in artemisinin crystallization
in Organic Process Research & Development
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509644/1 | 01/10/2016 | 30/09/2021 | |||
| 1783036 | Studentship | EP/N509644/1 | 01/07/2016 | 31/12/2019 | Samir Diab |
| Description | EU Cost Action Grant |
| Amount | € 1,420 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2017 |
| End | 09/2017 |
| Description | John Moyes Lessells Travel Scholarship |
| Amount | £3,640 (GBP) |
| Organisation | Royal Society of Edinburgh (RSE) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 05/2018 |
| Description | Society of Chemical Industry (SCI) Richardson Bursary |
| Amount | £850 (GBP) |
| Organisation | Society of Chemical Industry |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 12/2018 |
| Description | Attending and presenting at PSE@ResearchDayUK 2017 (Imperial College, London, UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited oral presentation at PSE@ResearchDayUK 2017 at Imperial College (London, UK) of my research on "Systematic antisolvent selection for diphenhydramine crystallisation in continuous pharmaceutical manufacturing." |
| Year(s) Of Engagement Activity | 2017 |
| Description | Attending and presenting at the 2018 AIChE Annual Meeting (Pittsburgh, PA, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attending and delivering two oral presentations, entitled "Optimal design of separation systems for the continuous manufacturing of nevirapine, an active pharmaceutical ingredient (API) for HIV treatment" and "Process modelling, simulation and optimisation of continuous biopharmaceutical manufacturing", at the 2018 American Institute for Chemical Engineers (AIChE) Annual Meeting (Pittsburgh, PA, USA). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Attending and presenting at the 28th European Symposium on Computer Aided Process Engineering (ESCAPE-28) (Graz, Austria) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attending and delivering an oral presentation at the 28th European Symposium on Computer Aided Process Engineering (ESCAPE-28) (Graz, Austria) on my research on "Process modelling, simulation and technoeconomic optimisation for continuous pharmaceutical manufacturing of (S)-warfarin." |
| Year(s) Of Engagement Activity | 2018 |
| Description | Attending and presenting at the 2nd Green and Sustainable Chemistry Conference (Berlin, Germany) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attendance and poster presentation at the 2nd Green and Sustainable Chemistry Conference in Berlin, Germany, presenting research on "Systematic Antisolvent Selection for Diphenhydramine Crystallisation on Continuous Pharmaceutical Manufacturing" to academic and industrial conference attendees. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Attending and presenting at the 3rd EuCheMS Congress on Green and Sustainable Chemistry (York, UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Attendance and oral presentation at the 3rd European Chemical Society (EuCheMS) Congress on Green and Sustainable Chemistry (York, UK), presenting research on "Technoeconomic Evaluation and Antisolvent Selection for Crystallisation in Continuous Pharmaceutical Manufacturing: Ibuprofen and Diphenhydramine" |
| Year(s) Of Engagement Activity | 2017 |
| Description | Oral presentation at the 2017 AIChE Annual Meeting (Minneapolis, MN, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation at the 2017 American Institute for Chemical Engineers (AIChE) Annual Meeting (Minneapolis, MN, USA) by my PhD supervisor of my research on "Technoeconomic evaluation of cyclosporine crystallisation using a cascade of MSMPR crystallisers." |
| Year(s) Of Engagement Activity | 2017 |
| Description | Poster presentation at the 2016 AIChE Annual Meeting (San Francisco, CA, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation at the 2016 American Institute for Chemical Engineers (AIChE) Annual Meeting (San Francisco, CA, USA) by my PhD supervisor of my research on "Systematic technoeconomic comparison of separation solvents for green continuous manufacturing." |
| Year(s) Of Engagement Activity | 2016 |