Computational modelling of separation processes for green continuous pharmaceutical manufacturing

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Engineering

Abstract

Continuous pharmaceutical manufacturing (CPM) has been shown to provide significant cost savings and reduction of material requirements and waste compared to the currently used, yet inefficient, batch methods. With the highest research and development costs of all industrial sectors, and historically increasing commercialisation costs, technological innovation is essential for pharmaceutical firms to remain profitable and sustainable. For the benefits of CPM to be realised by industry, demonstration of its feasibility and viability is paramount. The proposed PhD project looks to focus on the environmental benefits of CPM by process modelling and simulation of drug purification and separation stages. Non-linear programming of separation processes using rigorous thermodynamic modelling will be implemented to provide insights into the best separation process options. This will showcase the green benefits of CPM over the current batch paradigm, and contribute work to further the switch from batch to continuous manufacturing in the pharmaceutical industry today.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 01/10/2016 30/09/2021
1783036 Studentship EP/N509644/1 01/07/2016 31/12/2019 Samir Diab
 
Description EU Cost Action Grant
Amount € 1,420 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2017 
End 09/2017
 
Description John Moyes Lessells Travel Scholarship
Amount £3,640 (GBP)
Organisation Royal Society of Edinburgh (RSE) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 05/2018
 
Description Society of Chemical Industry (SCI) Richardson Bursary
Amount £850 (GBP)
Organisation Society of Chemical Industry 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2018 
End 12/2018
 
Description Attending and presenting at PSE@ResearchDayUK 2017 (Imperial College, London, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited oral presentation at PSE@ResearchDayUK 2017 at Imperial College (London, UK) of my research on "Systematic antisolvent selection for diphenhydramine crystallisation in continuous pharmaceutical manufacturing."
Year(s) Of Engagement Activity 2017
 
Description Attending and presenting at the 2018 AIChE Annual Meeting (Pittsburgh, PA, USA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Attending and delivering two oral presentations, entitled "Optimal design of separation systems for the continuous manufacturing of nevirapine, an active pharmaceutical ingredient (API) for HIV treatment" and "Process modelling, simulation and optimisation of continuous biopharmaceutical manufacturing", at the 2018 American Institute for Chemical Engineers (AIChE) Annual Meeting (Pittsburgh, PA, USA).
Year(s) Of Engagement Activity 2018
 
Description Attending and presenting at the 28th European Symposium on Computer Aided Process Engineering (ESCAPE-28) (Graz, Austria) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Attending and delivering an oral presentation at the 28th European Symposium on Computer Aided Process Engineering (ESCAPE-28) (Graz, Austria) on my research on "Process modelling, simulation and technoeconomic optimisation for continuous pharmaceutical manufacturing of (S)-warfarin."
Year(s) Of Engagement Activity 2018
 
Description Attending and presenting at the 2nd Green and Sustainable Chemistry Conference (Berlin, Germany) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Attendance and poster presentation at the 2nd Green and Sustainable Chemistry Conference in Berlin, Germany, presenting research on "Systematic Antisolvent Selection for Diphenhydramine Crystallisation on Continuous Pharmaceutical Manufacturing" to academic and industrial conference attendees.
Year(s) Of Engagement Activity 2017
 
Description Attending and presenting at the 3rd EuCheMS Congress on Green and Sustainable Chemistry (York, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Attendance and oral presentation at the 3rd European Chemical Society (EuCheMS) Congress on Green and Sustainable Chemistry (York, UK), presenting research on "Technoeconomic Evaluation and Antisolvent Selection for Crystallisation in Continuous Pharmaceutical Manufacturing: Ibuprofen and Diphenhydramine"
Year(s) Of Engagement Activity 2017
 
Description Oral presentation at the 2017 AIChE Annual Meeting (Minneapolis, MN, USA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral presentation at the 2017 American Institute for Chemical Engineers (AIChE) Annual Meeting (Minneapolis, MN, USA) by my PhD supervisor of my research on "Technoeconomic evaluation of cyclosporine crystallisation using a cascade of MSMPR crystallisers."
Year(s) Of Engagement Activity 2017
 
Description Poster presentation at the 2016 AIChE Annual Meeting (San Francisco, CA, USA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Poster presentation at the 2016 American Institute for Chemical Engineers (AIChE) Annual Meeting (San Francisco, CA, USA) by my PhD supervisor of my research on "Systematic technoeconomic comparison of separation solvents for green continuous manufacturing."
Year(s) Of Engagement Activity 2016