Structural and Functional Studies of Cannabidiol Interactions With Voltage-gated Sodium Channels

Lead Research Organisation: Birkbeck, University of London
Department Name: Biological Sciences

Abstract

Using structural and biophysical methods to explore the interactions between cannabidiol and voltage-gated sodium ion channels, using the prokaryotic sodium ion channel NavMs as a model.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013867/1 30/09/2016 29/09/2025
1905211 Studentship MR/N013867/1 30/09/2017 29/09/2021
 
Title Crystallographic Coordinates of 6Yz2 
Description crystal structure coordinated deposited in the pdb 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Crystallographic coordiantes used by other researchers 
 
Title PDB 6YZ0 
Description Crystallographic coordinates deposited in the Protein Data Bank 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Used by structural Biologists 
 
Description Collaboration with Simon Fraser University, Canada 
Organisation Simon Fraser University
Country Canada 
Sector Academic/University 
PI Contribution The Wallace team (Birkbeck) did all the structural and bioinformatics aspects of the partnership
Collaborator Contribution Prof P. Ruben's lab did the electrophysilogy aspects of the partnership, leading to a joint publication
Impact Publication (2020) in Elife which was also reported in an article written by the Diamond Light Source (and on their website).
Start Year 2020
 
Description GW Pharmaceuticals collaboration 
Organisation GW Pharmaceuticals
Country United Kingdom 
Sector Private 
PI Contribution Carrying out research into the interaction between CBD and VGSCs. GW deals in CBD, thus it is important that its interactions are understood.
Collaborator Contribution They provided CBD for the experiments.
Impact On-going experiments and investigations into the structural interaction between CBD and VGSCs.
Start Year 2019