Harnessing the Melanocortin System (MCS) to moderate inflammation and enhance healthy ageing
Lead Research Organisation:
Queen Mary University of London
Department Name: William Harvey Research Institute
Abstract
Inflammation is an evolutionary conserved biological response in mammals characterised by cell recruitment and release of critical chemokines/cytokines, growth factors and peptide hormones that orchestrate the protective reaction and lead to resolution and tissue repair. Two major cell types that coordinate these responses are macrophages and fibroblast. With age inflammation become prolonged and fails to resolve. The melanocortins have critical roles in regulating inflammation by modulating cell recruitment, adhesion and cytokine release. This project will explore the melanocortin pathways in inflammation and discover the key receptors and ligands that mediate the inflammatory function of macrophages and their
interaction with fibroblast.
interaction with fibroblast.
Publications
Khodeneva N
(2022)
Melanocortin therapies to resolve fibroblast-mediated diseases.
in Frontiers in immunology
Davan-Wetton C
(2021)
Senescence under appraisal: hopes and challenges revisited
in Cellular and Molecular Life Sciences
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M009513/1 | 30/09/2015 | 31/03/2024 | |||
2096137 | Studentship | BB/M009513/1 | 30/09/2018 | 30/11/2022 | Camilla Davan Wetton |