Harnessing the Melanocortin System (MCS) to moderate inflammation and enhance healthy ageing

Lead Research Organisation: Queen Mary, University of London
Department Name: William Harvey Research Institute

Abstract

Inflammation is an evolutionary conserved biological response in mammals characterised by cell recruitment and release of critical chemokines/cytokines, growth factors and peptide hormones that orchestrate the protective reaction and lead to resolution and tissue repair. Two major cell types that coordinate these responses are macrophages and fibroblast. With age inflammation become prolonged and fails to resolve. The melanocortins have critical roles in regulating inflammation by modulating cell recruitment, adhesion and cytokine release. This project will explore the melanocortin pathways in inflammation and discover the key receptors and ligands that mediate the inflammatory function of macrophages and their
interaction with fibroblast.

Publications

10 25 50
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Davan-Wetton CSA (2021) Senescence under appraisal: hopes and challenges revisited. in Cellular and molecular life sciences : CMLS

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M009513/1 01/10/2015 30/09/2023
2096137 Studentship BB/M009513/1 01/10/2018 30/11/2022 Camilla Sophie Davan Wetton