The neural correlates of phantom sensations and phantom limb pain
Lead Research Organisation:
University of Oxford
Department Name: Clinical Neurosciences
Abstract
Phantom limb pain (PLP) is a debilitating condition, occurring after limb amputation.
Traditionally, PLP is thought to be driven by maladaptive plasticity in the sensorimotor cortex1. However, treatment associated with such neural hypotheses (e.g. mirror-box therapy) report limited success.
Study 1) Plasticity in the neighbouring body part to the deprived hand region, and its relationship to phantom limb pain: this study aims to address the extent of maladaptive plasticity after amputation and it's association to phantom pain.
Study 2) How does impaired sensorimotor control influence the processing of nociception?: this study aims to use a reinforcement learning model (which models predictions and prediction errors) in the context of an active nociceptive learning task, thereby addressing study 1-3 below.
Study 3) Peripheral and central contributions to phantom sensation: here we are using peripheral (highly-detailed EMG electrode arrays) and central (MRI) correlates of phantom sensations and looking at their relative contributions to phantom perception.
Traditionally, PLP is thought to be driven by maladaptive plasticity in the sensorimotor cortex1. However, treatment associated with such neural hypotheses (e.g. mirror-box therapy) report limited success.
Study 1) Plasticity in the neighbouring body part to the deprived hand region, and its relationship to phantom limb pain: this study aims to address the extent of maladaptive plasticity after amputation and it's association to phantom pain.
Study 2) How does impaired sensorimotor control influence the processing of nociception?: this study aims to use a reinforcement learning model (which models predictions and prediction errors) in the context of an active nociceptive learning task, thereby addressing study 1-3 below.
Study 3) Peripheral and central contributions to phantom sensation: here we are using peripheral (highly-detailed EMG electrode arrays) and central (MRI) correlates of phantom sensations and looking at their relative contributions to phantom perception.
Organisations
People |
ORCID iD |
Irene Tracey (Primary Supervisor) | |
Victoria Root (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/N013468/1 | 30/09/2016 | 29/09/2025 | |||
2106798 | Studentship | MR/N013468/1 | 30/09/2018 | 30/05/2022 | Victoria Root |
MR/R502224/1 | 30/09/2017 | 30/05/2022 | |||
2106798 | Studentship | MR/R502224/1 | 30/09/2018 | 30/05/2022 | Victoria Root |