Nanoscale dissection of the Ephrin-Eph Receptor signalling axis in cellular invasion
Lead Research Organisation:
Queen Mary University of London
Department Name: Barts Cancer Institute
Abstract
Juxtacrine cellular cross-talk is critical during development, allowing leader and follower cells to communicate during angiogenesis and neuronal migration. One key axis mediating this process is Ephrin-Eph receptor signalling. Ephrin ligands induce forward signalling in neighbouring cells expressing Eph receptor tyrosine kinases, but also exhibit reverse signalling within the Ephrin-expressing cell. As with many developmental pathways, this signalling is recapitulated in disease, for example in pancreatic cancer invasion. We will use genetic engineering and super-resolution microscopy, in 2D/3D cell-based models to interrogate the dynamics of this reverse signalling, providing crucial insights into the regulation and function of this signalling axis.
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/T008709/1 | 30/09/2020 | 29/09/2028 | |||
2546576 | Studentship | BB/T008709/1 | 30/09/2021 | 29/09/2025 | Cerian Bolton |