Nanoscale dissection of the Ephrin-Eph Receptor signalling axis in cellular invasion

Lead Research Organisation: Queen Mary, University of London
Department Name: Barts Cancer Institute


Juxtacrine cellular cross-talk is critical during development, allowing leader and follower cells to communicate during angiogenesis and neuronal migration. One key axis mediating this process is Ephrin-Eph receptor signalling. Ephrin ligands induce forward signalling in neighbouring cells expressing Eph receptor tyrosine kinases, but also exhibit reverse signalling within the Ephrin-expressing cell. As with many developmental pathways, this signalling is recapitulated in disease, for example in pancreatic cancer invasion. We will use genetic engineering and super-resolution microscopy, in 2D/3D cell-based models to interrogate the dynamics of this reverse signalling, providing crucial insights into the regulation and function of this signalling axis.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/T008709/1 30/09/2020 29/09/2028
2546576 Studentship BB/T008709/1 26/09/2021 29/09/2025 Cerian Bolton