Nanoscale dissection of the Ephrin-Eph Receptor signalling axis in cellular invasion

Lead Research Organisation: Queen Mary, University of London
Department Name: Barts Cancer Institute

Abstract

Juxtacrine cellular cross-talk is critical during development, allowing leader and follower cells to communicate during angiogenesis and neuronal migration. One key axis mediating this process is Ephrin-Eph receptor signalling. Ephrin ligands induce forward signalling in neighbouring cells expressing Eph receptor tyrosine kinases, but also exhibit reverse signalling within the Ephrin-expressing cell. As with many developmental pathways, this signalling is recapitulated in disease, for example in pancreatic cancer invasion. We will use genetic engineering and super-resolution microscopy, in 2D/3D cell-based models to interrogate the dynamics of this reverse signalling, providing crucial insights into the regulation and function of this signalling axis.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/T008709/1 30/09/2020 29/09/2028
2546576 Studentship BB/T008709/1 26/09/2021 29/09/2025 Cerian Bolton