Centre for Integrative Physiology and Pharmacology at Imperial

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description As described in previous responses, the programme was responsible for training a number of MRes and PhD students in in vivo skills, and supporting in vivo training, and the careers of researchers working within in vivo research.
Exploitation Route The students trained have gone on to many different careers, including within academic science and industry. The research findings made have contributed significantly to the literature in a number of fields, which have been built on by other researchers.
Sectors Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description The major aim of the centre was to train young scientists to perform the physiological and pharmacological studies needed to understand the functions of genes, identify new drug targets and biomarkers, explore the pharmacokinetic properties of novel drugs and to facilitate the development of new medicines. The training programmes associated with the Centre trained 48 students to MRes level in such skills, and at least 30 subsequently began PhD training. In addition, the research staff associated with the Centre have continued to be promoted, make new findings and to train their own teams in in vivo techniques.
First Year Of Impact 2012
Sector Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic

 
Description MRC clinical research fellowship (Anjali Amin). 'Role of T1R1/T1R3 in satiety' 2013-2016
Amount £294,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2013 
End 06/2016
 
Description NC3Rs grant
Amount £270,000 (GBP)
Funding ID G0800720/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Reduction and refinement of murine models of bacterial infection
Amount £270,000 (GBP)
Funding ID G0800720/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 12/2011
 
Description Animals in research workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals.
Year(s) Of Engagement Activity 2016
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CIMPP received a grant from the Society for Endocrinology to put on demonstrations at the Cheltenham Science Festival
(June 2012). The students (Ellie Hughes, Helen Smith, Renee Schalks, Katherine Banks and Paul Holloway) created ways
to present emotions, attraction, appetite and exercise in a programme entitled, 'How Are Your Hormones'. Hundreds of
children and adults participated.
Year(s) Of Engagement Activity 2012
 
Description Combat my Cough 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Event to keep our patients up to date with the work we are doing in our clinic and through our research to find a cure for chronic cough. The event provoked questions and discussion, and patients suggesting they would change behaviours.
Year(s) Of Engagement Activity 2013,2014,2015,2016
URL https://www.combatmycough.com/events
 
Description Combat my Cough - Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Presentation explaining our research to a group of chronic cough patients from a specialist cough clinic in Manchester.
Year(s) Of Engagement Activity 2016
URL https://www.combatmycough.com/events
 
Description Symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A two day symposium (Animal Models and their Value in Predicting Drug Efficacy
and Toxicity, hosted jointly by the CIMPP, King's and New York Academy of Science) attracted approx 200 delegates from
academia, pharma and regulatory bodies; discussions were lively and emphasised (a) the importance of scientists
informing their studies with a better understanding of disease complexity (reverse translation) and (b) bias in the literature
resulting from difficulties of publishing 'negative data' from well designed studies.
Year(s) Of Engagement Activity 2011
 
Description Talk at MRC Asthma Centre - "Environmental asthma triggers and sensory irritation in the airway: contribution to the asthma phenotype" (September 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on current research
Year(s) Of Engagement Activity 2016
 
Description The Science Museum's Dana Centre, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A series of public discussions at the Science Museum's Dana Centre was organised in 2011/12. Speakers (including
students) from CIMPP talked openly about animal research in context with wider health issues such as neurodegeneration.
In two events (Greying Matters and Brain Evolution) students put on displays and talked informally to the audience about
their research.
No Pain, No Gain
Breathless
Fat of the Land
Greying Matters (in collaboration with the Society for Immunology)
Magic of Medicine (with the British Pharmacological Society)
Brain Evolution (with the British Neuroscience Association)
Year(s) Of Engagement Activity 2011
 
Description Workshop on the use of animals in research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals.
Year(s) Of Engagement Activity 2016