The Systems Biology of Exercise

Lead Research Organisation: University of Leeds
Department Name: Institute of Membrane & Systems Biology

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Benson AP (2013) A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. in Journal of applied physiology (Bethesda, Md. : 1985)

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Benson AP (2012) A validated and optimised model linking muscle and pulmonary oxygen uptake kinetics in Virtual Physiological Human Annual Conference

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Bowen TS (2014) The spatial distribution of absolute skeletal muscle deoxygenation during ramp-incremental exercise is not influenced by hypoxia in Proceedings of the International Society for Oxygen Transport to Tissue

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Bowen TS (2012) A dynamic overshoot in skeletal muscle deoxygenation is not evidence of a VO2 kinetic limitation in Medicine and Science in Sport and Exercise

 
Description This project was to support a partnership between Researchers in the UK (Leeds, Liverpool) and Japan (Kobe, Hiroshima, Tskuba) to bring together international expertise in regular meetings to progress the computational modelling of systems (cardiovascular, neuromuscular, pulmonary) interactions during exercise.

The team aimed to access immobile regional resources (e.g. multi-channel, time-resolved, near-infrared spectroscopy and chemical shift magnetic resonance spectroscopy) through collaboration. This aim has been very successful and has led to multiple publications, particularly using time-resolved, near-infrared spectroscopy (TRS NIRS). We have shown that TRS NIRS can be used to assess the matching of oxygen delivery to utilization in muscle at different depths and that O2 delivery limitations can lead to slowed rate of oxidative phosphorylation in muscle. Applications of this technology after the award finished have included in healthy subjects for academic research and clinical populations (in intensive care and sickle cell anaemia)

The team also build sustainable long term links through exchange of young researchers (post-doctoral and post-graduate) between partner laboratories. This aim has been successful with the exchange of several UK and Japanese students between the host labs. Three of these students went on to get personal post-doctoral fellowship fuding to continue their research in other universities.

The group also met an additional aim of hosted an international conference on the Systems Biology of Exercise at the University of Leeds in 2012.
Exploitation Route These findings have been used to help develop projects investigating the utility of quantitative time-resolved near-infrared spectroscopy in healthy subjects, as clinical tool to monitor adequacy or perfusion in patients in intensive care, and in academic research of exercise in healthy children and in pediatric patients with sickle cell anaemia. Papers associated with this project have been cited 102 times (Scopus, accessed Feb 19, 2017).
Sectors Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Pharmaceuticals and Medical Biotechnology

 
Description Collaboration with Universities of Kobe and Tokyo 
Organisation Kobe Design University
Country Japan 
Sector Academic/University 
PI Contribution Through the international Partnering Award, the PDRA employed on this grant was able to travel to Japan for 10 days to collaborate with Kobe University and Tokyo University. The outcome of this travel and collaborative work is a new manuscript focusing on the biochemical control of muscle contraction (currently under preparation).
Start Year 2012
 
Description Collaboration with Universities of Kobe and Tokyo 
Organisation University of Tokyo
Country Japan 
Sector Academic/University 
PI Contribution Through the international Partnering Award, the PDRA employed on this grant was able to travel to Japan for 10 days to collaborate with Kobe University and Tokyo University. The outcome of this travel and collaborative work is a new manuscript focusing on the biochemical control of muscle contraction (currently under preparation).
Start Year 2012
 
Description American College of Sports Medicine, South Western Chapter, Newport Beach CA, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Talk sparked questions and discussion

None known to date
Year(s) Of Engagement Activity 2014
 
Description American Health Journal interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 2016, Mar 27 TV Interview with "American Health Journal" Aired on KVCR and PBS TV in Los Angeles
http://www.thedoctorshow.com
Year(s) Of Engagement Activity 2016
URL https://vimeo.com/160808833
 
Description Mind over muscle: what limits human performance? 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBSRC Press release: Mind over muscle: what limits human performance?
Year(s) Of Engagement Activity 2016
URL http://bbsrc.tumblr.com/post/148686657371/mind-over-muscle-what-limits-human-performance
 
Description National Heart & Lung Institute, Imperial College London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Stimulated discussion and questions

None to date
Year(s) Of Engagement Activity 2013
 
Description Research visit for HBR and GJK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact HBR and GJK visited Japan for a research project and give presentations at special symposia at the Institute of Health and Sports Science, University of Tsukuba, Tsukuba, and the Faculty of Human Development, Kobe University.

No actual impacts realised to date
Year(s) Of Engagement Activity 2013
 
Description School of Gerontology, University of Southern California, Los Angeles CA, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Sparked questions and discussion

None to date
Year(s) Of Engagement Activity 2013