Enhanced Rice quality for Health (EnRicH)

Lead Research Organisation: Rothamsted Research
Department Name: Plant Sciences

Abstract

Rice is a staple food for more than half of the world's population. However, rice is largely consumed as polished grain (white rice) and its consumption, as part of the adoption of a Western diet and increasingly sedentary life style, is associated with increased risk of a range of chronic diseases including type 2 diabetes, obesity, cardio-vascular disease and forms of cancer. Hence it is important to consider the impact of rice on nutrition and health as well as traditional quality attributes. Consequently, the two most important targets for quality improvement of polished white rice are to reduce the rate of digestion in the human gastrointestinal tract (through starch structure manipulation and increasing the percentage of resistant starch) and increase the content of dietary fibre while retaining high yield and good cooking and sensory properties.
The research project will carry out detailed analyses of grain composition of a wide range of rice lines to identify lines with increased health benefits combined with good consumer acceptability. Cutting-edge genetics and bioinformatics will then be used to identify molecular markers that can be used to select for quality traits by breeders.
The improved lines and markers will then be delivered to national and international rice breeding programmes to allow them to develop new commercial varieties.

Planned Impact

The project will bring together major rice research groups in the Philippines and major cereal researchers in the UK at Rothamsted Research. RRes scientists have established research programmes on cereal improvement, in particular the Cell Wall Group has a strong research interest in improving wheat quality with the aim of delivering improved diet and health. The Philippine partners have substantial programmes of research on rice improvement. IRRI is part of the CGIAR system of agricultural research centres with a mandate to lead rice improvement and to translate food and nutritional security in S Asia and SE Asia. DA-PhilRice is the national rice research institute in the Philippines which aims to help develop high-yielding and cost-reducing technologies for farmers, including improved rice varieties.
The partners are committed to provide an infrastructure for research and collaboration beyond the time span of the current grant. A "legacy" of shared platforms for genotyping, rapid screens and data management; and of trained staff, students and early career scientists, will facilitate future research and collaboration on rice improvement within and between the two countries. The partnership will also increase the academic impact of both research communities in international rice research.
In the longer term the project will provide improved health to large populations through diet based interventions in one of the major staples of diet in Asia, at low cost and to improve social welfare.
Dissemination.
1. The primary direct beneficiaries from this project are rice breeders in the target regions who will be provided with elite breeding materials and with state of the art molecular markers and training in their use. Both IRRI and PhilRice have established pathways for dissemination and delivery of improved germplasm to national and international breeders. These include talks, discussions and field demonstrations of improved technologies and agronomic package of practices. Within the Philippines this will make use of the Philippines National Agricultural Research and extension systems (NARES).
2. Publications: a schedule for publication will be agreed, including preparing review articles for journals of wide circulation to rice researchers and other stakeholders, including farmers and breeders, in the Philippines. Primary research data will be published in open access articles in broad scope international refereed journals. Significant findings will be highlighted in press releases issued in the UK and the Philippines.
3. Data from the project will be made freely available to the global rice community on the IRRI web site
4. Presentations will be made at local, national and international meetings of the scientific community such as the Crop Science Society of the Philippines Scientific Conference, the International Rice Congress.
5. Wider communication to the general public will be made via institute open days, public meetings and articles in local publications. This will be aided by press releases highlighting the relevance of the work to food security and environmental sustainability.
 
Description Rothamsted Research has analysed the cell wall polysaccharides in polished grain of a diversity panel of 370 rice lines. We have identified variation in amount, by over three-fold, and composition. Statistical analysis was used to divide the lines into 10 groups which differed in both total amount and composition, with current rice breeding lines being intermediate in content. This is important as the level of dietary fibre has an impact on how fast the starch in rice grains is digested. This is of significance as if starch is digested fast, the rice is said to have a high GI (Glycaemic Index) value and consumption of foods with a high GI are associated with increased risks of a number of chronic diseases, including type II diabetes. The study therefore demonstrated that substantial variation exists in the content and composition of the major dietary fibre fraction of polished rice which should be amenable to exploitation by breeders to incorporate the beneficial high fibre trait in improved rice cultivars while maintaining high yields and high consumer acceptability. This could contribute to reduced burdens of diet-related chronic diseases globally. Partners in the Philippines have been involved in field trials and consumer-trial testing of rice lines with high increased levels of DF (DA-PhilRice- Department of Agriculture- Philippine Rice Research Institute). Amylose content (one component of starch, crucial for quality determination) was analysed at IRRI (International Rice Research Institute) in the diverse rice line panel. Differences in starch structure, were linked to information about the genes associated with starch biosynthesis and degradation. These data can be used to help rice breeders select rice lines with less easily digested starch but still acceptable to consumers.
Exploitation Route Make available genomic information/markers related to high fibre/low GI rice when available.
Make rice lines available to National and International rice breeding programmes with high dietary fibre.
Sectors Agriculture

Food and Drink

Healthcare

 
Description Greater awareness of need to increase fibre to reduce risk factors for a number of NCDs such as type 2 diabetes, obesity for eg. Various outreach projects in Philippines- especially via DA- PhilRice in the Philippines
First Year Of Impact 2018
Sector Agriculture, Food and Drink
Impact Types Policy & public services

 
Description BB/GCRF-IAA/17/18
Amount £9,600 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 02/2018
 
Description GCRF-IAA
Amount £4,350 (GBP)
Funding ID BB/GCRF-IAA/17/18 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 02/2018
 
Description GCRF-IAA
Amount £5,250 (GBP)
Funding ID BB/GCRF-IAA/17/18 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 02/2018
 
Description Improving the nutritional value and digestibility of rice to address double burden malnutrition in the Philippines and Thailand
Amount £1,012,374 (GBP)
Funding ID BB/T008873/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 02/2023
 
Description RRES GNCA- Relationships between Fibre Content and Starch Digestion in Brown and White Rice
Amount £30,000 (GBP)
Organisation Rothamsted Research 
Sector Academic/University
Country United Kingdom
Start 11/2022 
End 12/2022
 
Description Relationships between Fibre Content and Starch Digestion in Brown and White Rice. UKRI-GCRF/Newton Consolation account (GNCA)
Amount £32,937 (GBP)
Organisation Rothamsted Research 
Sector Academic/University
Country United Kingdom
Start 09/2022 
End 01/2023
 
Description Philippines partners 
Organisation International Rice Research Institute
Department Grain Quality and Nutrition Center
Country Philippines 
Sector Charity/Non Profit 
PI Contribution Rothamsted has a major programme on the biosynthesis and composition of wheat dietary fibre and its role in human health. We have identified a high level of variation in the content of the major dietary fibre components in wheat flour and bran fractions, with a substantial proportion of this variation being heritable and hence appropriate for selection in breeding programmes. We bring expertise in a suite of analytical techniques for fibre analysis, based on state of the art analytical equipment, including HP-AEC-PAD, HP-SEC-MALS, mass spectrometry, including MALDI-Tof, Q-traps, Orbitrap; GC-FID and GC-MS allowing detailed analysis of cell wall polysaccharides. We now intend to use this expertise to develop tools to analyse cell wall polysaccharides in diverse rice germplasm to improve the dietary fibre content in high yielding rice cultivars.
Collaborator Contribution IRRI brings extensive expertise in the domain of grain quality and nutrition, plant breeding related activities, effective agronomic management expertise, impact assessment and extension value chain with a well established network of varietal delivery systems. Analytical platforms related to size exclusion chromatography, resistant starch (RS) measurements and comprehensive grain quality profiling methods with ISO 17025 accredited facilities. Expertise in rice genomics, associating phenotypic characteristics with genetic factors to measure quality traits that relate to biochemical composition, flavor, and texture. Bioinformatic tools related to genome-wide association studies (GWAS) have been established for the detection of major and minor QTLs and fine mapping of the QTLs underlying complex traits of grain quality from untapped germplasm. DA-PhilRice conduct grain quality analysis particularly in sensory evaluation, employing laboratory and consumer panelists. DA-PhilRice also provides field trialling facilities.
Impact No outputs as yet.
Start Year 2016
 
Description Philippines partners 
Organisation Philippine Rice Research Institute
Country Philippines 
Sector Public 
PI Contribution Rothamsted has a major programme on the biosynthesis and composition of wheat dietary fibre and its role in human health. We have identified a high level of variation in the content of the major dietary fibre components in wheat flour and bran fractions, with a substantial proportion of this variation being heritable and hence appropriate for selection in breeding programmes. We bring expertise in a suite of analytical techniques for fibre analysis, based on state of the art analytical equipment, including HP-AEC-PAD, HP-SEC-MALS, mass spectrometry, including MALDI-Tof, Q-traps, Orbitrap; GC-FID and GC-MS allowing detailed analysis of cell wall polysaccharides. We now intend to use this expertise to develop tools to analyse cell wall polysaccharides in diverse rice germplasm to improve the dietary fibre content in high yielding rice cultivars.
Collaborator Contribution IRRI brings extensive expertise in the domain of grain quality and nutrition, plant breeding related activities, effective agronomic management expertise, impact assessment and extension value chain with a well established network of varietal delivery systems. Analytical platforms related to size exclusion chromatography, resistant starch (RS) measurements and comprehensive grain quality profiling methods with ISO 17025 accredited facilities. Expertise in rice genomics, associating phenotypic characteristics with genetic factors to measure quality traits that relate to biochemical composition, flavor, and texture. Bioinformatic tools related to genome-wide association studies (GWAS) have been established for the detection of major and minor QTLs and fine mapping of the QTLs underlying complex traits of grain quality from untapped germplasm. DA-PhilRice conduct grain quality analysis particularly in sensory evaluation, employing laboratory and consumer panelists. DA-PhilRice also provides field trialling facilities.
Impact No outputs as yet.
Start Year 2016
 
Description RRES GNCA -Relationships between Fibre Content and Starch Digestion in Brown and White Rice 
Organisation Philippine Rice Research Institute
Country Philippines 
Sector Public 
PI Contribution Writing grant proposal and exchange of personnel, training.
Collaborator Contribution Provision research samples, expertise regarding attributes of rice grain quality in the Philippines.
Impact Training of Philippines research staff in measurement of dietary fibre. Knowledge exchange in Philippines regarding importance of increasing fibre intake. Personnel exchange- including training of UK researcher in the Philippines.
Start Year 2022
 
Description SuperNutrientRice 
Organisation National Institute of Agronomy and Botany (NIAB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Fibre analysis of rice lines. Statistical analysis of combined data.
Collaborator Contribution NIAB-Phytochemical analysis of rice lines to link with genomic data obtained to previous project IRRI- Social-economic- nutritional impact of introducing nutrient- improved rice to Philippines KCL-Mineral availability in rice lines
Impact N/A yet. Preparation of data for publication in discussions
Start Year 2020
 
Description Alison Lovegrove Keynote UK Rice Research Community ECR Workshop. University of Essex September, 2023 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Alison Lovegrove Keynote UK Rice Research Community ECR Workshop. University of Essex September, 2023. "Improving the quality of staple foods to deliver health benefits".
Year(s) Of Engagement Activity 2023
 
Description Baltic wheat Workshop, Malmo Sweden. 23-25th May 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Baltic wheat Workshop, Malmo Sweden. 23-25th May.- Organised by Peter Shewry. Researchers from DSW (JIC, Earlham, Rothamsted, University of Bristol) organised by Peter Shewry meeting researchers from the Baltic wheat network- Sweden, Denmark, Lithuania, Latvia, Finland, Estonia, and Wheat breeders
Year(s) Of Engagement Activity 2023
 
Description Institute Accelerator Award (IAA) to attend the TriSociety (2023 ASA, CSSA, SSSA) INTERNATIONAL ANNUAL MEETING, St Louis. (29th Oct-1st Nov) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Institute Accelerator Award (IAA) for Peter Shewry, Alison Lovegrove, Anneke Prins and Maria Oszvald for travel and conference costs to attend the TriSociety (2023 ASA, CSSA, SSSA) INTERNATIONAL ANNUAL MEETING, St Louis. (29th Oct-1st Nov). This meeting will include a special workshop for Coalition for Grain Fibre collaborators- at which Alison Lovegrove and Peter Shewry presented.
Year(s) Of Engagement Activity 2023
 
Description Processing workshop hosted by UK Millers April 2023 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Processing workshop hosted by UK Millers and organised by Peter Shewry. London 19th April (formally NABIM). UK researchers ( with an emphasis on ECRs) from DSW attended, also collaborators from the University of Reading. Talks from Heads of research from industry- millers and bakers industry talks ( Heygates, ATC, Warburtons, ADM and also a representative from AHDB)
Year(s) Of Engagement Activity 2023
 
Description XIV International Gluten Workshop (IGW), Madrid. 19th-22 June 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Peter Shewry Keynote Speaker.
Alison Lovegrove on Organising committee.
Alison Lovegrove gave talk with Itria Maria Ibba (Head of Wheat Quality lab CIMMYT Mexico) at 'Women in Wheat Quality' Session- 'Speed-dating' mentoring session.
Expert Working Group meeting at end of IGW.
Alison Lovegrove gave talk on dietary fibre research.
Members discussed the 'Coalition for Grain Fibre' initiative begun following discussions between Peter Shewry and Steve Greenspan and Rod Wallace. The Coalition for Grain Fiber " is an International coalition of scientific researchers (UK, Europe, America, Mexico) and FIHF (Foundation for Innovation in Healthy Food) partners across the grain supply chain with healthcare and community interest groups to increase the amount of fiber in the grain-based food that consumers choose to eat."
Year(s) Of Engagement Activity 2023