How the gut reacts to stress: changes in intestinal stem cell behaviour in response to perturbation of the enteric nervous system.

Lead Research Organisation: Quadram Institute
Department Name: Gut Health and Food Safety



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Description We have discovered that proliferation of small intestinal cells is enhanced in situations of chronic stress
Exploitation Route By elucidating the mechanisms of interaction between the enteric nervous system and the epithelium, new strategies could be developed to reduce the impact of nervous stress on inflammatory bowel disease patients
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

Description Michel Neunlist 
Organisation National Institute of Health and Medical Research (INSERM)
Department DR2 INSERM
Country France 
Sector Public 
PI Contribution Mathematical modelling of epithelial stem cell proliferation and differentiation during acute and chronic stress
Collaborator Contribution Technology to experimentally evaluate the enteric nervous system and confocal microscopy
Impact N/A
Start Year 2015