Italy-Croatia-Poland-UK partnership - The GLI Transcription Factors: From Upstream Regulators to Downstream Targets

Lead Research Organisation: University of Leeds
Department Name: Sch of Molecular & Cellular Biology

Abstract

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Publications

10 25 50
 
Description Strategic funding
Amount £5,288 (GBP)
Funding ID N/A 
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 06/2022 
End 03/2025
 
Description BBSRC -IPA 
Organisation Ruder Boskovic Institute
Country Croatia 
Sector Public 
PI Contribution Starting collaboration through an International Partnering Award - officially beginning in April 2022
Collaborator Contribution Partners will contribute to development of a Hedgehog signalling website resource and provide genetically modified human-derived cancer cell lines, advanced training in mass spec of GLI proteins PTMs, and transgenic mice.
Impact First Hh signalling workshop organised in January 2023 at the University of Leeds. 20 delegates attended and presented talks in a 2-day networking event.
Start Year 2022
 
Description BBSRC -IPA 
Organisation Sapienza University of Rome
Country Italy 
Sector Academic/University 
PI Contribution Starting collaboration through an International Partnering Award - officially beginning in April 2022
Collaborator Contribution Partners will contribute to development of a Hedgehog signalling website resource and provide genetically modified human-derived cancer cell lines, advanced training in mass spec of GLI proteins PTMs, and transgenic mice.
Impact First Hh signalling workshop organised in January 2023 at the University of Leeds. 20 delegates attended and presented talks in a 2-day networking event.
Start Year 2022
 
Description BBSRC -IPA 
Organisation University of Warsaw
Country Poland 
Sector Academic/University 
PI Contribution Starting collaboration through an International Partnering Award - officially beginning in April 2022
Collaborator Contribution Partners will contribute to development of a Hedgehog signalling website resource and provide genetically modified human-derived cancer cell lines, advanced training in mass spec of GLI proteins PTMs, and transgenic mice.
Impact First Hh signalling workshop organised in January 2023 at the University of Leeds. 20 delegates attended and presented talks in a 2-day networking event.
Start Year 2022
 
Description Collaboration with Dr. Pawel Niewiadomski 
Organisation University of Warsaw
Country Poland 
Sector Academic/University 
PI Contribution We have provided proteomic datasets for cross-referencing and contributed to many brainstorming sessions to guide PhD and postdoctoral researcher projects.
Collaborator Contribution The partner has contributed key unpublished data, methods and a large amount of new cell lines and plasmids for generation of preliminary data for grant applications.
Impact Nothing to report yet.
Start Year 2023
 
Description Collaboration with Prof. Lucia Di Marcotullio 
Organisation Sapienza University of Rome
Country Italy 
Sector Academic/University 
PI Contribution This collaboration to study the microenviroment of medulloblastoma tumours will use spatial proteomics expertise in house as well as functional studies of validation of Erap1 in Hh signalling. I will provide lab space, consumables support, travel and lodging, and access to spatial proteomics of mouse tissue.
Collaborator Contribution The collaborator will contribute mouse medulloblastoma tissue blocks of different phenotypes, collected by the PhD student, and dedicated time of the student to spend in my lab in Leeds as part of her PhD as well as costly antibodies. I have become officially a co-supervisor in the project.
Impact Not yet
Start Year 2024