Italy-Croatia-Poland-UK partnership - The GLI Transcription Factors: From Upstream Regulators to Downstream Targets
Lead Research Organisation:
University of Leeds
Department Name: Sch of Molecular & Cellular Biology
Abstract
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Organisations
- University of Leeds (Lead Research Organisation)
- Sapienza University of Rome (Collaboration)
- University of Warsaw (Collaboration, Project Partner)
- Ruder Boskovic Institute (Collaboration)
- ISPRO (Project Partner)
- Sapienza University of Rome (Project Partner)
- Rudjer Boskovic Institute (Project Partner)
Description | Strategic funding |
Amount | £5,288 (GBP) |
Funding ID | N/A |
Organisation | University of Leeds |
Sector | Academic/University |
Country | United Kingdom |
Start | 06/2022 |
End | 03/2025 |
Description | BBSRC -IPA |
Organisation | Ruder Boskovic Institute |
Country | Croatia |
Sector | Public |
PI Contribution | Starting collaboration through an International Partnering Award - officially beginning in April 2022 |
Collaborator Contribution | Partners will contribute to development of a Hedgehog signalling website resource and provide genetically modified human-derived cancer cell lines, advanced training in mass spec of GLI proteins PTMs, and transgenic mice. |
Impact | First Hh signalling workshop organised in January 2023 at the University of Leeds. 20 delegates attended and presented talks in a 2-day networking event. |
Start Year | 2022 |
Description | BBSRC -IPA |
Organisation | Sapienza University of Rome |
Country | Italy |
Sector | Academic/University |
PI Contribution | Starting collaboration through an International Partnering Award - officially beginning in April 2022 |
Collaborator Contribution | Partners will contribute to development of a Hedgehog signalling website resource and provide genetically modified human-derived cancer cell lines, advanced training in mass spec of GLI proteins PTMs, and transgenic mice. |
Impact | First Hh signalling workshop organised in January 2023 at the University of Leeds. 20 delegates attended and presented talks in a 2-day networking event. |
Start Year | 2022 |
Description | BBSRC -IPA |
Organisation | University of Warsaw |
Country | Poland |
Sector | Academic/University |
PI Contribution | Starting collaboration through an International Partnering Award - officially beginning in April 2022 |
Collaborator Contribution | Partners will contribute to development of a Hedgehog signalling website resource and provide genetically modified human-derived cancer cell lines, advanced training in mass spec of GLI proteins PTMs, and transgenic mice. |
Impact | First Hh signalling workshop organised in January 2023 at the University of Leeds. 20 delegates attended and presented talks in a 2-day networking event. |
Start Year | 2022 |
Description | Collaboration with Dr. Pawel Niewiadomski |
Organisation | University of Warsaw |
Country | Poland |
Sector | Academic/University |
PI Contribution | We have provided proteomic datasets for cross-referencing and contributed to many brainstorming sessions to guide PhD and postdoctoral researcher projects. |
Collaborator Contribution | The partner has contributed key unpublished data, methods and a large amount of new cell lines and plasmids for generation of preliminary data for grant applications. |
Impact | Nothing to report yet. |
Start Year | 2023 |
Description | Collaboration with Prof. Lucia Di Marcotullio |
Organisation | Sapienza University of Rome |
Country | Italy |
Sector | Academic/University |
PI Contribution | This collaboration to study the microenviroment of medulloblastoma tumours will use spatial proteomics expertise in house as well as functional studies of validation of Erap1 in Hh signalling. I will provide lab space, consumables support, travel and lodging, and access to spatial proteomics of mouse tissue. |
Collaborator Contribution | The collaborator will contribute mouse medulloblastoma tissue blocks of different phenotypes, collected by the PhD student, and dedicated time of the student to spend in my lab in Leeds as part of her PhD as well as costly antibodies. I have become officially a co-supervisor in the project. |
Impact | Not yet |
Start Year | 2024 |