Understanding the interplay between fermentable carbohydrate, colonic short chain fatty acid profile and gut hormone release
Lead Research Organisation:
Imperial College London
Department Name: Metabolism, Digestion and Reproduction
Abstract
In England, 60% of the adult population is overweight or obese. The situation is alarming due to the side effects of excessive fat storage which are health risks for cardiovascular disease, diabetes, and even cancer. The health risk associated with obesity is not just related to total amount of fat but the where in the body the fat is stored. There for it becomes a priority to understand how dietary components can maintain energy homeostasis across the lifespan.
An important dietary component that is present at much lower levels in modern diets compared to that of our ancient ancestors, the hunter-gatherers, is fermentable carbohydrates. Fermentable carbohydrates, obtained from eating foods high in fibre, are not digested and so enter the colon, where they are available for fermentation by resident gut bacteria. Diets high in non-digestible carbohydrate that is fermented in the colon, has a beneficial effect on the structure of the fat tissue and its distribution in the body. Important products of the fermentation process are short chain fatty acids (SCFAs) and there is increasing evidence that they mediate the beneficial effects of dietary fermentable carbohydrate. We will focus our study on how food structure will impact on how the distinct sites in the gut processes carbohydrates (both amount and physical form) in to SCFAs. Cells communicate to each other by sending and responding to chemical messages. SCFAs are a set of many different kinds of messages that act through cell surface receptors called G protein-coupled receptors (GPCRs), so called due to the mechanism of how these receptors transmit chemical messages in to the cell. The SCFAs activate two distinct GPCRs, FFA2 and FFA3. Although many currently prescribed drugs target some of these GPCRs, there is a high demand for drugs where treatments are more specific, have fewer side effects, and that are active for longer. To do this we must first understand the molecules that make up the cell machinery controlling the activity of these receptors. Although it is known that SCFAs can cause the gut hormone-producing cell of the colon, the enteroendocrine cell, to increase in number, very little is known about the way different SCFAs induce signals via their GPCRs in these enteroendocrine cells and where these receptors are located. Therefore further key goals of this project is to understand the signal pathways in the cells that these receptors activate in response to alterations in SCFAs. We will also develop novel biochemical tools to understand location of the receptor across enteroendocrine cells. Both timing and location of GPCR signals will be studied as it is critical for programming cells, telling it whether to release more hormone, activate particular genes, divide, or even die.
Using food structure to target SCFA production at a specific site of the colon could be an important population-wide intervention to maintain energy homeostasis. This project will lead to not only a greater understanding on the impact of SCFAs on entroendocrine cells but also identify potential nutrition and drug targets. The project will give a deep understanding of the how dietary carbohydrate structure impacts of colonic appetite signalling through interventional studies in humans. It will use novel chemical biological probes and to unpick receptor signalling to different SCFA
An important dietary component that is present at much lower levels in modern diets compared to that of our ancient ancestors, the hunter-gatherers, is fermentable carbohydrates. Fermentable carbohydrates, obtained from eating foods high in fibre, are not digested and so enter the colon, where they are available for fermentation by resident gut bacteria. Diets high in non-digestible carbohydrate that is fermented in the colon, has a beneficial effect on the structure of the fat tissue and its distribution in the body. Important products of the fermentation process are short chain fatty acids (SCFAs) and there is increasing evidence that they mediate the beneficial effects of dietary fermentable carbohydrate. We will focus our study on how food structure will impact on how the distinct sites in the gut processes carbohydrates (both amount and physical form) in to SCFAs. Cells communicate to each other by sending and responding to chemical messages. SCFAs are a set of many different kinds of messages that act through cell surface receptors called G protein-coupled receptors (GPCRs), so called due to the mechanism of how these receptors transmit chemical messages in to the cell. The SCFAs activate two distinct GPCRs, FFA2 and FFA3. Although many currently prescribed drugs target some of these GPCRs, there is a high demand for drugs where treatments are more specific, have fewer side effects, and that are active for longer. To do this we must first understand the molecules that make up the cell machinery controlling the activity of these receptors. Although it is known that SCFAs can cause the gut hormone-producing cell of the colon, the enteroendocrine cell, to increase in number, very little is known about the way different SCFAs induce signals via their GPCRs in these enteroendocrine cells and where these receptors are located. Therefore further key goals of this project is to understand the signal pathways in the cells that these receptors activate in response to alterations in SCFAs. We will also develop novel biochemical tools to understand location of the receptor across enteroendocrine cells. Both timing and location of GPCR signals will be studied as it is critical for programming cells, telling it whether to release more hormone, activate particular genes, divide, or even die.
Using food structure to target SCFA production at a specific site of the colon could be an important population-wide intervention to maintain energy homeostasis. This project will lead to not only a greater understanding on the impact of SCFAs on entroendocrine cells but also identify potential nutrition and drug targets. The project will give a deep understanding of the how dietary carbohydrate structure impacts of colonic appetite signalling through interventional studies in humans. It will use novel chemical biological probes and to unpick receptor signalling to different SCFA
Technical Summary
In England, 60% of the adult population is overweight or obese. There is an urgent need to understand how dietary components effect appetite regulation. Research from our group, has demonstrated that increased dietary intake of fermentable carbohydrate promotes weight loss. We have also demonstrated that high intakes of carbohydrates enter the colon and are fermented by the microbiotia producing short chain fatty acids (SCFAs), stimulating the release of the anorectic gut peptides PYY and GLP-1 from enteroendocrine cells. Using a novel method to deliver the SCFA propionate to the colon we have shown release of PYY and GLP-1 with a reduction in food intake. However little is known how food structure influences SCFA production. It can be hypothesized that the form of diet could impact on the ileum content and subsequent SCFA production in the colon, and thus the release of PYY and GLP-1. The colon has the highest density of enteroendocrine cells that produce PYY with an increasing gradient from the ascending colon to the rectum. Therefore fermentation of carbohydrate in the transverse and descending colon may stimulate greater production of PYY and GLP-1 via altered SCFA production. SCFAs, acetate, propionate and butyrate, in the colon signal via two distinct G protein-coupled receptors, FFA2 and FFA3, whose activity in the gut is poorly characterized. Our data suggests that exposing the colon to SCFAs increases entroendocrine cell differentiation specifically via FFA2. Crucially, very little is known about both receptor distribution and the intracellular signaling pathways controlling enteroendocrine cell function. In this project we will employ both in vivo and in vitro human colon and organoid systems and multidisciplinary technologies to identify, i) the impact food structure makes on the site and production of SCFA and ii) mechanistic regulation of SCFA action in the human colon and its potential reprogramming by diet.
Planned Impact
This project aims to address one of UKs major diet-related health challenges, obesity. In this project we want to understand the relationship between food structure and carbohydrate driven release of PYY and GLP-1 through change in colonic short chain fatty acid (SCFA) production. It therefore has huge potential long term impact on a wide range of stakeholders from consumers to policy makers. In addition to the academic beneficiaries, the outputs of the research will impact on the following stakeholder groups:-
Food Industry: Fermentable carbohydrates yield SCFAs, the endogenous agonists of SCFA receptors FFA2 and FFA3. Therefore the outputs from this project and the further research it will generate will enable the food industry to develop a new generation of foods targeted at body composition to reduce the incidence of type 2 diabetes. Foods with high nutritional impact is a growing sector of the food industry and robust scientific evidence of positive health benefits arising from this and future projects will support health claims and further growth, giving the UK food industry a competitive advantage. The generic knowledge produced will allow approaches to be developed to improve control over rates of nutrient delivery.
The human physiological studies will give new methodology. The project will develop new biological chemical tools to give a deep synoptic understanding. Both will be available to the scientific community.
Consumers: Individual consumers will have new knowledge regarding the health benefits of fermentable carbohydrate, together with a wider choice of manufactured foods with specific, proven health benefits. Although care has to be taken with the health communication aspects as consumption of these foods may only be effective as part of a healthy balanced diet. The foods ought to have comparable consumer acceptability, making it more convenient for consumers to adopt healthier options. The long term health benefits of reducing obesity and the risks associated with diabetes will benefit the lifelong health, wellbeing of individuals and improve the quality of life into old age.
National Health Service and Government: This project is the first step in understanding how dietary carbohydrate, which is fermented to SCFA's and the release of anorectic gut hormones, leads to changes in appetite regulation. The number of individuals diagnosed with type 2 diabetes in the UK has roughly doubled since 1996 to about 2.6 million. The direct costs to the NHS and other health care providers for treating obesity and related conditions is currently around £10 billion per year (approx. 10% of the NHS budget). The total costs of diabetes to the nation including direct care and indirect costs are estimated to be £23.7 billion due to subsequent loss of working days due to sickness and loss of productivity. Any reduction in the prevalence of diabetes would have a huge impact through fewer admissions, fewer surgical interventions and fewer prescriptions, which would clearly have an impact on health costs. The data produced by the project will also enable the development of dietary advice for ameliorating the health problems in those who have already developed the early signs of diabetes.
Food Industry: Fermentable carbohydrates yield SCFAs, the endogenous agonists of SCFA receptors FFA2 and FFA3. Therefore the outputs from this project and the further research it will generate will enable the food industry to develop a new generation of foods targeted at body composition to reduce the incidence of type 2 diabetes. Foods with high nutritional impact is a growing sector of the food industry and robust scientific evidence of positive health benefits arising from this and future projects will support health claims and further growth, giving the UK food industry a competitive advantage. The generic knowledge produced will allow approaches to be developed to improve control over rates of nutrient delivery.
The human physiological studies will give new methodology. The project will develop new biological chemical tools to give a deep synoptic understanding. Both will be available to the scientific community.
Consumers: Individual consumers will have new knowledge regarding the health benefits of fermentable carbohydrate, together with a wider choice of manufactured foods with specific, proven health benefits. Although care has to be taken with the health communication aspects as consumption of these foods may only be effective as part of a healthy balanced diet. The foods ought to have comparable consumer acceptability, making it more convenient for consumers to adopt healthier options. The long term health benefits of reducing obesity and the risks associated with diabetes will benefit the lifelong health, wellbeing of individuals and improve the quality of life into old age.
National Health Service and Government: This project is the first step in understanding how dietary carbohydrate, which is fermented to SCFA's and the release of anorectic gut hormones, leads to changes in appetite regulation. The number of individuals diagnosed with type 2 diabetes in the UK has roughly doubled since 1996 to about 2.6 million. The direct costs to the NHS and other health care providers for treating obesity and related conditions is currently around £10 billion per year (approx. 10% of the NHS budget). The total costs of diabetes to the nation including direct care and indirect costs are estimated to be £23.7 billion due to subsequent loss of working days due to sickness and loss of productivity. Any reduction in the prevalence of diabetes would have a huge impact through fewer admissions, fewer surgical interventions and fewer prescriptions, which would clearly have an impact on health costs. The data produced by the project will also enable the development of dietary advice for ameliorating the health problems in those who have already developed the early signs of diabetes.
Publications
Shchepinova MM
(2020)
Chemical biology of noncanonical G protein-coupled receptor signaling: Toward advanced therapeutics.
in Current opinion in chemical biology
Shackley M
(2020)
Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gai/o Pathway.
in Frontiers in nutrition
Pingitore A
(2019)
Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2.
in Diabetes, obesity & metabolism
Morrison DJ
(2016)
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism.
in Gut microbes
Malkova D
(2020)
Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women.
in Metabolism: clinical and experimental
Lu B
(2023)
Impact of the short-chain fatty acid propionate on mesenteric adipose tissue and insulin sensitivity
in Proceedings of the Nutrition Society
Kounde CS
(2020)
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light.
in Chemical communications (Cambridge, England)
Khatib M
(2018)
A pilot study to evaluate the effect of increased colonic propionate on appetite during a hypocaloric diet
in Proceedings of the Nutrition Society
Khatib M
(2019)
A pilot study to evaluate the effect of increased colonic propionate on glucose homeostasis during a hypocaloric diet
in Proceedings of the Nutrition Society
Description | We have developed the tools to intubate the ileum and colon. The results a currently been brought together. We have shown a very dynamic microbiota and metabolite population. The aim is to develop a manuscript before the end of the year |
Exploitation Route | We will make all data available to the scientific community |
Sectors | Agriculture Food and Drink |
Description | We have had a partnership with Nestle and Heptares stimulated by this ward The human ileum contains a high density of enteroendocrine L-cells which release the appetite supressing hormones Glucagon-like peptide-1 (GLP-1) and Peptide Tyrosine Tyrosine (PYY) in response to food intake. Recent evidence highlighted the potential role of food structures in PYY release. In a randomised cross over trial, we investigated the role of human ileum in GLP-1 and PYY release by giving healthy volunteers diets differing in fibre and food structure: High fibre (intact or disrupted structures) and low fibre disrupted structures. We used nasoenteric tubes to sample from an intact ileum (fasted and every 60min for 480min postprandially). We demonstrate for the first time the highly dynamic, wide ranging molecular environment of the ileum, with a dramatic drop in the ileum bacterial population and bacterial metabolites following food intake. We also show that dietary fibre, independent of its structure, induces metabolite profile changes in the ileum that relate to the release of PYY. High fibre diets increased PYY release compared to a low fibre diet during 0-240min. High fibre diets also increased ileal stachyose and disrupted high fibre diet increased certain ileal amino acids. Treatment of human ileal organoids with ileal fluids or amino acid and stachyose mixture stimulated PYY expression in a similar trend to blood PYY levels, confirming the role of ileal metabolites in PYY release. Our study demonstrated for the first time the diet induced changes over time in the metabolite environment of intact human ileum which play a role in PYY release. Trial Registration number: ISRCTN11327221 |
First Year Of Impact | 2023 |
Sector | Agriculture, Food and Drink,Digital/Communication/Information Technologies (including Software),Healthcare |
Impact Types | Societal Economic |
Description | A surface plasmon resonance facility for label-free analysis of biomolecular interactions |
Amount | £182,677 (GBP) |
Funding ID | BB/S019529/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2019 |
End | 06/2020 |
Description | Developing multiscale models of digestion to enable targeted product solutions for nutrition and metabolic health |
Amount | £350,000 (GBP) |
Funding ID | BB/P023851/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 11/2019 |
Description | Exploiting CaSR-mediated vagal signalling to treat type 2 diabetes |
Amount | £282,085 (GBP) |
Funding ID | 18/0005886 |
Organisation | Diabetes UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2019 |
End | 02/2022 |
Description | Understanding the impact of food structures on ileal metabolites and gut hormone release |
Amount | £5,000 (GBP) |
Organisation | British Nutrition Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2023 |
End | 01/2024 |
Description | DART |
Organisation | University of Leicester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am part of the founding commitee and a current committee member. We collaberate on on a number of grant applications through this consortium. |
Collaborator Contribution | as above |
Impact | We have run two workshop. The group is also applying for grants. The group is muti-diaplinary bring together physicians, health care scientist, allied health professionals. |
Start Year | 2019 |
Description | FFAR2 signaling |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Expertise in entroendocrine nutrient signaling |
Collaborator Contribution | Ed Tate- new chemical tools Aylin Hanyaloglu - receptor biology Kevin Murphy - gut hormone physiology |
Impact | Non at present |
Start Year | 2016 |
Description | Metabolite and nutrition partnership |
Organisation | Murdoch University |
Country | Australia |
Sector | Academic/University |
PI Contribution | This partnership will develop links around food metabolomics a food strucutures |
Collaborator Contribution | The phenome centre at Murdock Univesity will provide anylitical techniques to understand food strucutre |
Impact | It is too early in the collaberation to have impact |
Start Year | 2019 |
Description | Quadram Imperial Collaboration |
Organisation | Quadram Institute Bioscience |
Department | Food & Health Programme |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Human cutting edge research |
Collaborator Contribution | They provide the scientific hub for the collaberation |
Impact | Non at the present time |
Start Year | 2018 |
Description | Stable Isotope and Short Chain Fatty Acid Partnership |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This is an academic partnership with Dr Douglas Morrison. He has developed methods using stable isotopes to monitor the metabolic effects on diet. He is also a partner in the SCFA programme |
Collaborator Contribution | He leads the stable isopote analysis |
Impact | There are a number of grants and papers that have come from the partnership |
Start Year | 2010 |
Title | Novel food ingredient dossier submitter |
Description | Inulin propionate ester. WE have submitted the dossier for novel foods to the EU. This novel to phase 3 clinical trial |
Type | Products with applications outside of medicine |
Current Stage Of Development | Market authorisation |
Year Development Stage Completed | 2018 |
Development Status | Under active development/distribution |
Impact | This is potentially the only therapy for the prevention of weight gain. |
Description | BRIT Pact symposium of Arthritus |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This was a formal information giving lecture with a question and answer session |
Year(s) Of Engagement Activity | 2017 |
Description | British Dietetics Association Obesity Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Spoke to expert dietitian about hte potential role of the gut microbiota in dietetic practice |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.eventbrite.co.uk/e/bda-obesity-group-annual-conference-2020-tickets-69660236643# |
Description | British Nutrition Foundation Annual Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Presented an update on personalised nutrition to stimulate debated |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.nutrition.org.uk/training-and-events/conference-recordings/#:~:text=The%20British%20Nutr... |
Description | Clinical Mixer |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | 50 people listened to a short talk on the role of carbohydrate on health |
Year(s) Of Engagement Activity | 2021 |
Description | DRINC Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Spoke to 100 people about the results of our Primimg Food Partnership Grant |
Year(s) Of Engagement Activity | 2019 |
Description | ECNP epert panel |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Workshop to disseminate the influence of food on central neurological processing |
Year(s) Of Engagement Activity | 2017 |
Description | FENS conference Dublon |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Spoke to an audance of over 100 one food and the gut covering aspects from many of my awards |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.fens2019.org/ |
Description | Federation of European Neuroscience Societies Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Formal lecture to 150 nutirtional scientist |
Year(s) Of Engagement Activity | 2023,2024 |
URL | https://fensforum.org/ |
Description | Food digestion meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 400 scientist attended a two day meeting. I present the impact of fermentable carbohydrate on appetite regulation. Good audience feed back |
Year(s) Of Engagement Activity | 2017 |
Description | Food hackathon |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | 50 small to medium size enterprises will take part in a Hackaton aimed at finding a way forward and translation around legume foods and health |
Year(s) Of Engagement Activity | 2019,2020 |
URL | https://www.imperial.ac.uk/events/95859/food-hack-2020-translating-nutritional-research-into-product... |
Description | Food of tomorrow Science Museum |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Ran demonstrations of fermentable carbohydrate from a stall at the science museum |
Year(s) Of Engagement Activity | 2016 |
Description | Fructan Conference |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I gave a lecture and judge the posters. Good feed back at the lecture |
Year(s) Of Engagement Activity | 2016 |
Description | Future Foods Imperial Lates |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Over 4000 people attended the event. We diseminated information about food digestions and new ways to monitor food intake |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.imperial.ac.uk/events/167015/imperial-lates-future-food/ |
Description | Great Exibition Road Festival |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | We demonstrated how food is digested as the role of the microbiota. This sparked a lot of questions |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.imperial.ac.uk/events/160698/great-exhibition-road-festival-2023/ |
Description | Imperial Lates "Food for Thought" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | This was a science outreach week focused on food. If gaave feed back from the general public on our research |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.imperial.ac.uk/be-inspired/lates/food-for-thought/ |
Description | Imperial Murdoch Collaberation |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a two week research scoping exercise |
Year(s) Of Engagement Activity | 2023 |
Description | Imperial Science Festival - dissemination to general public |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | We had a two stands disseminating information in out work on dietary fibre and dietary assessment |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.imperial.ac.uk/festival/about/festival-2017/ |
Description | NIHR Imperial College BRC open day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Over 500 people attended the Imperial College NIHR open day where we demonstrated out work in the NIHR BRC |
Year(s) Of Engagement Activity | 2019 |
URL | https://imperialbrc.nihr.ac.uk/2019/09/22/nihr-imperial-research-open-day-friday-15th-november-2019/ |
Description | Nutrition Society Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 500 people listen to my talk on the role of short chain fatty acids on health |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.nutritionsociety.org/events/spring-conference-2021-gut-microbiome-and-health |
Description | Nutrition Society Winter Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | We had a stand at the conference to engage people in the network |
Year(s) Of Engagement Activity | 2023 |
Description | Presentaion to Cambridge metabolic group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | 50 post doctoral scientist attended the workshop on short chain fatty acids. The talk raised a number of questions and suggestion |
Year(s) Of Engagement Activity | 2018 |
Description | Rank Prize conference - Designing Food Structure to Control Digestion and Improve Health Impacts |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | 60 young scientist attended a week long workshop to understand the role of food structure. The aim was to develop interest in this area |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.rankprize.org/index.php/symposia |
Description | Rank Prize meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a two day workshop where we shared some on the results for this award |
Year(s) Of Engagement Activity | 2022 |
Description | Symposium on Designing Food Structure to Control Digestion and Improve Health Impacts - Understanding the Interplay Between, Food Structure, Gut Microbiota and Appetite Sensing |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Information given on out current work on diagetion |
Year(s) Of Engagement Activity | 2019 |
Description | Visit to Norway to talk to opinion makes about Nutrition |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Talk to 15 Norwegian opinion leaders about the role of Nutrition in the prevention of non communicable disease highlighting my research |
Year(s) Of Engagement Activity | 2019 |
Description | Workshop at DAVOS |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | 120 people attended a science update at DAVOS. My talk was on the double hit of Malnutritiion |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.weforum.org/events/world-economic-forum-annual-meeting-2018 |