Japan Partnering Award: The Generation of Eye Tissues from Human Induced Pluripotent Stem (iPS) Cells.
Lead Research Organisation:
Cardiff University
Department Name: Optometry and Vision Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Watanabe S
(2021)
Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities.
in iScience
Wang K
(2020)
Cell compaction is not required for the development of gradient refractive index profiles in the embryonic chick lens.
in Experimental eye research
Shiraki N
(2022)
PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids
in Stem Cell Reports
Shibata S
(2018)
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages
in Cell Reports
Nomi K
(2021)
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs.
in Cell reports
Matsushita K
(2023)
Barium-induced toxic anterior segment syndrome.
in European journal of ophthalmology
Maruyama K
(2022)
Diagnosis of Choroidal Disease With Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography
in Translational Vision Science & Technology
Kobayashi Y
(2020)
Ocular surface ectoderm instigated by WNT inhibition and BMP4.
in Stem cell research
Hayashi R
(2022)
Generation of 3D lacrimal gland organoids from human pluripotent stem cells
in Nature
Description | Initial meetings have taken place between vision researchers in Cardiff, Newcastle, Nottingham, UCL, Osaka, Kyoto and Kobe and three of proposed six ECR PDRA placements have taken place. |
Exploitation Route | UK-Japan collaborations in the vision sciences will be established. |
Sectors | Healthcare |
Description | Dr Yixin Wang research in Osaka University |
Organisation | Osaka University |
Country | Japan |
Sector | Academic/University |
PI Contribution | My PhD student, Dr Yixin Wang, conducted experiments in Osaka University on human induced pluripotent stem cells and extracellular matrix molecules that is advancing our knowledge and will lead to publications in the next year or so |
Collaborator Contribution | Professor Ryuhei Hayashi hosted Dr Wang and provided training and mentorship |
Impact | None yet |
Start Year | 2014 |
Description | JPA collaboration |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research collaboration between Cardiff Newcastle and Osaka |
Collaborator Contribution | Research collaboration between Cardiff Newcastle and Osaka |
Impact | None yet |
Start Year | 2018 |
Description | JPA link Nottingham Trent |
Organisation | Nottingham Trent University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New research in lens development and beamtime at the Japan synchrotron |
Collaborator Contribution | New research in lens development and beamtime at the Japan synchrotron |
Impact | Data being written up |
Start Year | 2018 |
Description | Nishida SEAM collaboration |
Organisation | Osaka University |
Country | Japan |
Sector | Academic/University |
PI Contribution | The joint ongoing study of iPS cell derived eye-like cells |
Collaborator Contribution | The joint ongoing study of iPS cell derived eye-like cells |
Impact | Preliminary, unpublished data as part of this new collaborative project with long-standing partners |