From Peptides to Mimetics: Towards Smaller More Stable Drug-like Protein-protein Interaction Inhibitors
Lead Research Organisation:
University of Bath
Department Name: Biology and Biochemistry
Abstract
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Publications
Brennan A
(2020)
Selective antagonism of cJun for cancer therapy.
in Journal of experimental & clinical cancer research : CR
Brennan A
(2022)
The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist.
in Cell reports. Physical science
Brennan A
(2022)
An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity.
in JACS Au
Hoang H
(2020)
Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides
in Chemical Science
Leech JT
(2022)
In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun.
in The Journal of biological chemistry
Madden SK
(2021)
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.
in Molecular cancer
Meade RM
(2021)
A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding.
in Journal of molecular biology
Nadal-Bufi F
(2021)
Designed ß-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity.
in Journal of medicinal chemistry
Nadal-Bufí F
(2022)
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation.
in Cellular and molecular life sciences : CMLS
Yu M
(2021)
Combined computational and intracellular peptide library screening: towards a potent and selective Fra1 inhibitor.
in RSC chemical biology
| Company Name | Revolver Therapeutics |
| Description | Revolver Therapeutics researches and develops peptide-based inhibitors with the aim of producing treatments for cancers currently considered undruggable. |
| Year Established | 2023 |
| Impact | Revolver has only recenely spunout and is developing lead molecules and seeking fundraising. |
| Website | http://www.revolvertherapeutics.com/ |
| Description | In cellulo library-derived peptide-based inhibitors of alpha-synuclein aggregation and toxicity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | International Peptide Symposium, Brisbane 2023 |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.peptides2023.org/ |
| Description | Invited speaker at 11th annual conference of the International Chemical Biology Society (ICBS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | https://icbs2022.chemical-biology.org/invited-speakers |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://icbs2022.chemical-biology.org/invited-speakers |