From Peptides to Mimetics: Towards Smaller More Stable Drug-like Protein-protein Interaction Inhibitors

Lead Research Organisation: University of Bath
Department Name: Biology and Biochemistry

Abstract

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Publications

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Brennan A (2020) Selective antagonism of cJun for cancer therapy. in Journal of experimental & clinical cancer research : CR

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Nadal-Bufi F (2021) Designed ß-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity. in Journal of medicinal chemistry

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Nadal-Bufí F (2022) Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation. in Cellular and molecular life sciences : CMLS

 
Company Name Revolver Therapeutics 
Description Revolver Therapeutics researches and develops peptide-based inhibitors with the aim of producing treatments for cancers currently considered undruggable. 
Year Established 2023 
Impact Revolver has only recenely spunout and is developing lead molecules and seeking fundraising.
Website http://www.revolvertherapeutics.com/
 
Description In cellulo library-derived peptide-based inhibitors of alpha-synuclein aggregation and toxicity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact International Peptide Symposium, Brisbane 2023
Year(s) Of Engagement Activity 2023
URL https://www.peptides2023.org/
 
Description Invited speaker at 11th annual conference of the International Chemical Biology Society (ICBS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact https://icbs2022.chemical-biology.org/invited-speakers
Year(s) Of Engagement Activity 2022
URL https://icbs2022.chemical-biology.org/invited-speakers