Novel anti-malarial compounds and assay targeting chloroquine resistance

Lead Research Organisation: CARDIFF UNIVERSITY
Department Name: School of Biosciences


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Maughan SC (2010) Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. in Proceedings of the National Academy of Sciences of the United States of America

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Patzewitz EM (2013) Glutathione transport: a new role for PfCRT in chloroquine resistance. in Antioxidants & redox signaling

Description We discovered that the malaria gene conferring resistance to the frontline drug chloroquine is closely related to plant antioxidant transporters and investigated the function of these genes using yeast.
Exploitation Route Has been used as the basis for further research by others.
Sectors Healthcare

Description Extensive press coverage around the discovery that the chloroquine resistance gene of malaria is closely related to a class of plant specific transporters that are involved in antioxidant transport.
First Year Of Impact 2010
Sector Healthcare
Impact Types Societal