SMART-HIP: Smart bioactive nanocomposite coatings for enhanced hip protheses
Lead Research Organisation:
University of Sheffield
Department Name: Materials Science and Engineering
Abstract
Total hip joint replacements have become one of the most successful surgical procedures. Normally the procedure dramatically improves the quality of life for the recipient, eliminating the debilitating pain and restoring mobility. The implant would normally be expect to last for 10 to 20 years, in the standard patient, aged something over 60 years old. However, as a result of the success of the procedure, increasing numbers of individuals are requesting this procedure from a ever increasingly youthful population. With increasing life expectancy and this new group of younger patients, the demands on the performance of the prosthesis are ever increasing. Metal on metal prostheses have been shown to be an exciting new area for resurfacing and total hip replacements, reducing problems of osteolysis associated with the standard, metal on polymer implant, as well as allowing larger diameter prostheses to be used permitting a greater range of movement and less risk of dislocation. However, problems have been identified related to the biological response to both the metal particles and also the metal ion release and therefore there is a motivation to reduce both. This project will develop, test and study the properties of new nanocomposite, wear and ion release resistant PVD bioactive coatings, to meet the rigorous demands of the hip joint application. Performance will be assessed on a hip wear simulator to evaluate the longevity of the surface modifications. The nanoparticles generated in the hip wear simulator will be evaluated using state-of-the-art analytical methods. In addition to reducing wear and ion release, the nanocomposite coatings will offer novel multifunctional benefits of self-lubrication, antimicrobial properties and improved bedding in of the bearing surfaces. This proposal is a unique opportunity to further develop industry and university collaborations generated by: (1) the interdisciplinary nature of the group; (2) new developments in nanotoxicology; (3) coordinated, multifield testing of nanoparticles, including novel methods of assessing benefits and risks to health of humans from exposure to nanoparticles. This proposal will lead to the development of safer and more durable hip replacements. Moreover, the technology will also be applicable to other joint replacements and other articulating medical devices, including interspinal disc replacements.
Organisations
- University of Sheffield (Lead Research Organisation)
- Biotechnology and Biological Sciences Research Council (Co-funder)
- Cutting and Wear (Collaboration)
- Plasma Coatings Group (Collaboration)
- Keronite International (Collaboration)
- Cambridge Nanolitic Ltd (Collaboration)
- Wallwork-Cambridge/Tecvac Ltd (Collaboration)
Publications
Wang L
(2010)
Corrosion properties and contact resistance of TiN, TiAlN and CrN coatings in simulated proton exchange membrane fuel cell environments
in Journal of Power Sources
Liu X
(2017)
CrCuAgN PVD nanocomposite coatings: Effects of annealing on coating morphology and nanostructure
in Applied Surface Science
Mo J
(2013)
Impact wear and abrasion resistance of CrN, AlCrN and AlTiN PVD coatings
in Surface and Coatings Technology
Wang L
(2008)
Material transfer phenomena and failure mechanisms of a nanostructured Cr-Al-N coating in laboratory wear tests and an industrial punch tool application
in Surface and Coatings Technology
Jimenez O
(2008)
Structure and mechanical properties of nitrogen-containing Zr-Cu based thin films deposited by pulsed magnetron sputtering
in Journal of Physics D: Applied Physics
Chen Y
(2013)
Substrate and bonding layer effects on performance of DLC and TiN biomedical coatings in Hank's solution under cyclic impact-sliding loads
in Surface and Coatings Technology
Liu X
(2015)
The combined effects of Cu and Ag on the nanostructure and mechanical properties of CrCuAgN PVD coatings
in Surface and Coatings Technology
Audronis M
(2009)
The morphology and structure of PVD ZrN-Cu thin films
in Journal of Physics D: Applied Physics
Description | We confirmed the benefits of adding antibacterial/antimicrobial elements into coatings for prosthetic devices to avoid the psuedotumour problem. |
Exploitation Route | Implementation of the coatings by device manufacturers and coating companies. The coatings developed also have potential applications in other sectors such as Transport, Packaging and Aerospace. |
Sectors | Aerospace Defence and Marine Agriculture Food and Drink Healthcare Manufacturing including Industrial Biotechology Transport |
Description | Used in the development of new nanocomposite tribological coatings |
First Year Of Impact | 2011 |
Sector | Aerospace, Defence and Marine,Energy,Environment,Transport |
Impact Types | Societal Economic |
Description | Technology Strategy Board |
Amount | £76,000 (GBP) |
Funding ID | 4708-44211 |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 09/2011 |
End | 01/2015 |
Description | Link with industrial company |
Organisation | Cambridge Nanolitic Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provision of research support |
Collaborator Contribution | Provision of facilities and materials. |
Impact | New processes and products |
Start Year | 2006 |
Description | Link with industrial company |
Organisation | Cutting and Wear |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provision of research support |
Collaborator Contribution | Provision of facilities and materials. |
Impact | New processes and products |
Start Year | 2006 |
Description | Link with industrial company |
Organisation | Keronite International |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provision of research support |
Collaborator Contribution | Provision of facilities and materials. |
Impact | New processes and products |
Start Year | 2006 |
Description | Link with industrial company |
Organisation | Plasma Coatings Group |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provision of research support |
Collaborator Contribution | Provision of facilities and materials. |
Impact | New processes and products |
Start Year | 2006 |
Description | Link with industrial company |
Organisation | Wallwork-Cambridge/Tecvac Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provision of research support |
Collaborator Contribution | Provision of facilities and materials. |
Impact | New processes and products |
Start Year | 2006 |