Redistributed Manufacturing in Deployed Medical Care Network Plus
Lead Research Organisation:
University of the West of England
Department Name: Faculty of Business and Law
Abstract
Re-Distributed Manufacture (RDM) is defined as: "Technology, systems and strategies that change the economics and organisation of manufacturing, particularly with regard to location and scale" . In healthcare, RDM involves bringing production closer to the point of clinical need or use, enhancing the capability to deliver personalised medicine. The EPSRC funded Re-Distributed Manufacturing in Healthcare Network (RiHN- www.RiHN.org.uk) was launched in Feb 2015 and delivered by a consortium of six universities (UWE, Loughborough, Nottingham, Cambridge, Newcastle & Brunel), representing disciplines from both the social sciences and engineering and led an agenda to advance the impact of UK medical manufacturing.
One area of significant research interest identified by RiHN has been the potential value of implementing RDM approaches in deployed medical care. Whilst RDM includes the notion of a shift from centralised towards decentralised production, extant research continues to assume a degree of stable environmental conditions and fixed static location (e.g. hospitals/clinics/home). However, RDM can deliver life-saving benefits in mobile medical scenarios, where there is urgent and unforeseen demand in changing and remote locations, such as in response to natural disasters and emergencies (e.g. the Ebola crisis, Cyclone Idai and recent terrorist attacks), and the rapid treatment of injured military personnel in the field. This often requires a reverse supply chain perspective, starting with the requirement based on patient need. There are a variety of medical conditions that could benefit from rapid response treatments closer to the site of a medical emergency or in field hospitals; these include (but not limited to) blast injuries to skin and tissue, haemorrhagic shock and fractures.
The project will be led by a multi-disciplinary team bringing together subject matter experts that rarely meet, such as experts in trauma care, emergency medicine, innovation management and manufacturing, and will achieve the following outputs:
- A review of current research capability and knowledge- sharing of current breakthroughs
- Enhancing understanding of the use of RDM in deployed medical care
- Identification of and development of promising RDM technologies that support treatment pathways in deployed operations
- Capture of military and civilian emergency medical requirements and applications for RDM
- Systematic identification and comparison of needs, applications, technologies and resources
The overall outcome for the research will be the creation of 'communities of practice', producing real world demonstrators covering both the business and technical aspects of implementing RDM in deployed medical care, bringing the potential to advance the UK's capability in RDM, delivering impact to clinicians, practitioners and patients. The research will help shape how the UK Ministry of Defence, prime contractors in the defence sector, emergency and urgent care services and UK Research Council proceed with future R&D investment and resourcing. The outputs of the project will also be disseminated through a website, presentations at relevant national and international conferences, and research centres and a Special Issue journal (Health Services Management Research) and presenting the findings of the project at a showcase event. A final report will be produced, sent electronically to all interested parties, and made available digitally and via social media.
One area of significant research interest identified by RiHN has been the potential value of implementing RDM approaches in deployed medical care. Whilst RDM includes the notion of a shift from centralised towards decentralised production, extant research continues to assume a degree of stable environmental conditions and fixed static location (e.g. hospitals/clinics/home). However, RDM can deliver life-saving benefits in mobile medical scenarios, where there is urgent and unforeseen demand in changing and remote locations, such as in response to natural disasters and emergencies (e.g. the Ebola crisis, Cyclone Idai and recent terrorist attacks), and the rapid treatment of injured military personnel in the field. This often requires a reverse supply chain perspective, starting with the requirement based on patient need. There are a variety of medical conditions that could benefit from rapid response treatments closer to the site of a medical emergency or in field hospitals; these include (but not limited to) blast injuries to skin and tissue, haemorrhagic shock and fractures.
The project will be led by a multi-disciplinary team bringing together subject matter experts that rarely meet, such as experts in trauma care, emergency medicine, innovation management and manufacturing, and will achieve the following outputs:
- A review of current research capability and knowledge- sharing of current breakthroughs
- Enhancing understanding of the use of RDM in deployed medical care
- Identification of and development of promising RDM technologies that support treatment pathways in deployed operations
- Capture of military and civilian emergency medical requirements and applications for RDM
- Systematic identification and comparison of needs, applications, technologies and resources
The overall outcome for the research will be the creation of 'communities of practice', producing real world demonstrators covering both the business and technical aspects of implementing RDM in deployed medical care, bringing the potential to advance the UK's capability in RDM, delivering impact to clinicians, practitioners and patients. The research will help shape how the UK Ministry of Defence, prime contractors in the defence sector, emergency and urgent care services and UK Research Council proceed with future R&D investment and resourcing. The outputs of the project will also be disseminated through a website, presentations at relevant national and international conferences, and research centres and a Special Issue journal (Health Services Management Research) and presenting the findings of the project at a showcase event. A final report will be produced, sent electronically to all interested parties, and made available digitally and via social media.
Planned Impact
In summary, during a series of sandpit and workshop events, run by the EPSRC funded RiHN, the potential value of implementing RDM approaches in deployed, frontline operations was identified. Working with MoD Defence Medical Services (DMS), members of the RiHN team seek to open up a new line of investigation that has the potential to radically transform support to medical treatments in deployed operations, where there is urgent and unforeseen demand remote and changeable locations. The proposed Network will allow us to bring together a number of key experts and disciplines and advance a robust, structured agenda for further research with the aim of advancing the UK's capability in RDM and delivering impact to clinicians, practitioners and patients. This agenda will help shape how MoD, defence prime contractors, emergency services and UK Research Council proceed with future R&D investment and resourcing.
Beneficiaries include SMEs and defence prime contractors (suppliers of 3D printers and scanners, and manufacturers specialising in customised parts and therapies), clinicians within the NHS and MoD Defence Medical Services, who will define requirements and will be end users of new technologies and and systems that will allow the rapid, tailored and localised treatments of life-threatening and debilitating injuries, resulting in better patient outcomes. If there were a significant adoption of RDM, soldiers would receive an enhanced level of critical care when it is most required, which has the potential to reduce complications and long-term care costs incurred by the Ministry of Defence.
Clinicians operating in deployed operations often have to administer treatments in extreme conditions, facing needs that may help define future take up by the NHS. The practice of emergency and military medicine can be employed to evaluate novel healthcare approaches, and identify where RDM can add the most value in healthcare delivery.
Finally, the academic community will benefit from the Network, which will bring together those from diverse backgrounds to investigate applications beyond the mainstream clinical settings. For those from the social sciences, this will allow them to explore the role of lead users in shaping novel manufacturing technologies and systems, and an improved comprehension of the diffusion of disruptive innovations. For those from engineering and science, they will be provided with an insight into the working environment and issues of emergency and military medicine. All academic participants will have the opportunity to explore and critique their ideas leading to further proposals investigating the feasibility of RDM applications.
The proposed Network is well connected to key researchers in engineering and management, centres of innovative manufacturing, and specialists in military and emergency medicine - ensuring effective participation, dissemination and exploitation.
Beneficiaries include SMEs and defence prime contractors (suppliers of 3D printers and scanners, and manufacturers specialising in customised parts and therapies), clinicians within the NHS and MoD Defence Medical Services, who will define requirements and will be end users of new technologies and and systems that will allow the rapid, tailored and localised treatments of life-threatening and debilitating injuries, resulting in better patient outcomes. If there were a significant adoption of RDM, soldiers would receive an enhanced level of critical care when it is most required, which has the potential to reduce complications and long-term care costs incurred by the Ministry of Defence.
Clinicians operating in deployed operations often have to administer treatments in extreme conditions, facing needs that may help define future take up by the NHS. The practice of emergency and military medicine can be employed to evaluate novel healthcare approaches, and identify where RDM can add the most value in healthcare delivery.
Finally, the academic community will benefit from the Network, which will bring together those from diverse backgrounds to investigate applications beyond the mainstream clinical settings. For those from the social sciences, this will allow them to explore the role of lead users in shaping novel manufacturing technologies and systems, and an improved comprehension of the diffusion of disruptive innovations. For those from engineering and science, they will be provided with an insight into the working environment and issues of emergency and military medicine. All academic participants will have the opportunity to explore and critique their ideas leading to further proposals investigating the feasibility of RDM applications.
The proposed Network is well connected to key researchers in engineering and management, centres of innovative manufacturing, and specialists in military and emergency medicine - ensuring effective participation, dissemination and exploitation.
Organisations
- University of the West of England (Lead Research Organisation)
- Centre for Process Innovation (CPI) (Collaboration)
- Centillion Technology (Collaboration)
- Porton Biopharma Ltd (Collaboration)
- Defence Medical Services (Collaboration)
- SCITECH ENGINEERING LTD (Collaboration)
- James Cook University Hospital (Collaboration)
- Defence Science & Technology Laboratory (DSTL) (Collaboration)
- Quay Pharma (Collaboration)
- Research Complex at Harwell (Collaboration)
- MINISTRY OF DEFENCE (Collaboration)
- Centillion Technology Systems (CTS) (Collaboration)
- INNOVATE UK (Collaboration)
- East Midlands Medilink (Collaboration)
- Queen Elizabeth Hospital Birmingham (Project Partner)
- Scitech (Project Partner)
- Centillion Technology Ltd (Project Partner)
Publications
Bindi B
(2023)
Bioinspired Collagen/Hyaluronic Acid/Fibrin-Based Hydrogels for Soft Tissue Engineering: Design, Synthesis, and In Vitro Characterization.
in Journal of functional biomaterials
Fosso Wamba S
(2021)
Guest editorialEmerging technologies in emergency situations
in International Journal of Operations & Production Management
Howell C.J.;
(2022)
Innovation in deployed medical care: Building resilient healthcare supply chains
Kapletia D
(2023)
Healthcare Innovation - Shaping Future Models of Delivery
Kayali Y
(2022)
Effect of printing parameters on microscale geometry for 3D printed lattice structures
in Materials Today: Proceedings
Moradlou H
(2020)
Buyer-supplier collaboration during emerging technology development
in Production Planning & Control
Phillips W
(2022)
Global Value Chain Reconfiguration and COVID-19: Investigating the Case for More Resilient Redistributed Models of Production
in California Management Review
Phillips W
(2021)
Responding to information asymmetry in crisis situations: innovation in the time of the COVID-19 pandemic
in Public Management Review
Phillips W.;
(2022)
Innovation in deployed medical care: Building resilient healthcare supply chains
Title | A novel design-through-manufacture approach to transparant face orthosis for deployed medical environments. |
Description | Feasibility study video |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
Impact | Provided a publically available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of 3D printing of facial orthosis for use in deployed medicine. |
URL | https://www.youtube.com/watch?v=w3Glsr8nW1w |
Title | AMPlify: redistributed manufacturing of antimicrobial peptides for wound care |
Description | RiHN feasibility study video |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
Impact | Provided a publically available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of antimicrobial peptides for wound care in deployed medicine. |
URL | https://www.youtube.com/watch?v=XwxnS0Pij9k |
Title | Combining Orthobiologics, Antimicrobial and Angiogenic Properties for Rapid Treatment of Bone Repair in Deployed Settings |
Description | RiHN feasibility study video |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
Impact | Provided a publically available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of orthobiologics for use in deployed medicine. |
URL | https://www.youtube.com/watch?v=Oyd3Vg5UiEU |
Title | Cryopreservation and resuscitation of regeneratively primed skeletal 'myo-grafts' for autologous soft tissue repair in deployed surgical enviroments. |
Description | RiHN feasibility study video. |
Type Of Art | Film/Video/Animation |
Year Produced | 2022 |
Impact | Provided a publicly available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of a tissue therapies and personalised medicine, for application in deployed healthcare settings. |
URL | https://rihn.org.uk/fundedprojects/ |
Title | Decentralised manufacture of combi-pills at point of care |
Description | RiHN feasibility study video |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
Impact | Provided a publically available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of decentralised manufacture of combi-pills for use in deployed medicine. |
URL | https://www.youtube.com/watch?v=Q07DXK5visQ |
Title | Handheld Electrospinning of Antimicrobial Laminar Structures (HEALS) for simultaneous fabrication and application of micro and nanofibrous wound dressings. |
Description | RiHN Feasability study video |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
Impact | Provided an outline of the RiHN programme's funded project investigating the potential of electrospinning of wound dressings for deployed medical care. |
URL | https://www.youtube.com/watch?v=U7qK3p5mU9k |
Title | Personalised wound healing devices: using new additive manufacturing capabilities for previously impossible 3D geometries and functionality |
Description | RiHN feasibility study video. |
Type Of Art | Film/Video/Animation |
Year Produced | 2022 |
Impact | Provided a publicly available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of a novel wound healing technology which could deliver personalised medicine, in deployed healthcare settings. |
URL | https://rihn.org.uk/fundedprojects/ |
Title | Point-of-care of skin wounds via automated therapeutic layer-by-layer coatings |
Description | RiHN feasibility study video. |
Type Of Art | Film/Video/Animation |
Year Produced | 2022 |
Impact | Provided a publicly available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of a novel wound dressing technology which could improve patient outcomes in deployed healthcare settings. |
URL | https://rihn.org.uk/fundedprojects/ |
Title | Proof-of-concept of long-term storage of functional extra-cellular vesicles for application in accelerated soft-tissue and fracture healing |
Description | RiHN feasibility study video |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
Impact | Provided a publically available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential long-term storage of extra-cellular vesicles for wound healing in deployed medicine. |
URL | https://www.youtube.com/watch?v=rgIuzUaFjBI |
Title | The on-demand manufacture of potable and sterile water for emergency medical, humanitarian and healthcare applications using electrochemical activation production technologies |
Description | RiHN feasibility study video. |
Type Of Art | Film/Video/Animation |
Year Produced | 2022 |
Impact | Provided a publicly available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of a novel manufacturing technology which can deliver drinking water and sterilisation fluids on-demand, for application in deployed healthcare settings. |
URL | https://rihn.org.uk/fundedprojects/ |
Title | Ultrafast 3D printed personalised wound fillings for immediate stabilisation and regeneration of soft tissues. |
Description | RiHN feasibility study video. |
Type Of Art | Film/Video/Animation |
Year Produced | 2022 |
Impact | Provided a publicly available (via RiHN website/social media) outline of the RiHN programme's funded project investigating the potential of a novel tissue therapy to deliver personalised medicine and improved patient outcomes in deployed healthcare settings. |
URL | https://rihn.org.uk/fundedprojects/ |
Description | So far the Network has funded 13 feasibility studies that are undertaking research into redistributed manufacturing in four priority areas: clinical fluids manufacturing, additive layer manufacturing,cell and tissue manufacturing and pharmaceutical manufacturing. Some of these feasibility studies have completed and their findings presented in their final reports which areavailable on the RiHN website. We have also undertaken additional research to understand the operational requirement for RDM-led applications in deployed military operations and present the business case for RDM in deployed operations, culminating in the RiHN Final report |
Exploitation Route | The outcomes of the feasibility studies should hopefully lead to further funding of larger scale research projects. Some of the techologies being developed by the studies have gone to be field tested in a deployed medical scenario and following the outcome of the testing may move towards being used by practitioners of deployed medical care. The programme has identified the redistributed manufacture of blood as a priority area and we have received additional funding to explore this in more depth,. We have also received additiopnal EPSRC funding to establishing the operational and business models, and regulatory environment for point-of-care CAR-T manufacture, a cell and gene therapy. |
Sectors | Aerospace Defence and Marine Healthcare Government Democracy and Justice Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
URL | https://rihn.org.uk |
Description | The Programme has been impacted by the Covid-19 pandemic and so did not commence until the beginning of July 2020. However, Co-Is on the Programme, notably Prof Harris Makatoris, Prof Phillips and Dr Sam Roscoe have been interviewed by various media outlets regarding the impact of Covid on supply chains and healthcare manufacturing. Dr Sam Roscoe has provided recommendations to the International Trade Committee regarding building resilience into UK supply chains and these recommendations have been taken up by the UK Government and have resulted in a foundational level supply chain capability development programme which taught members of the DIT's Global Supply Chains Directorate how to identify the early warning signs of supply chain disruptions and develop strategies for overcoming disruptions. Building on the finings ofthe RiHN programme, the mHRA are about to launch a new point of care regulatory framework to support the manufacture of healthcare products and medicines close to the point of need. Our findings have also been used by UK defence to identify priority areas for research for the use of RDM in deployed operations and members of the research team have been invited to be expert members of MoD working group looking at redistributed manufacturing in defence medical services. Prof Wendy Phillips and Dr Helen Sanderson have also received additional funding from Dstl to explore the redistributed manufacture of blood products for the military and from the EPSRC to establishing the operational and business models, and regulatory environment for point-of-care CAR-T manufacture (a cell and gene therapy) |
First Year Of Impact | 2020 |
Sector | Aerospace, Defence and Marine,Healthcare,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
Impact Types | Societal Economic Policy & public services |
Description | Consultation on Point of Care manufacturing |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | The work to create the new POC regulatory framework is contained within the Second Sector Deal of the UK's Life Sciences Industrial Strategy as one of the 'innovative regulation' projects committed to by MHRA. The emergence of products manufactured and supplied at the POC were identified through a range of sources including engagement with the Engineering and Physical Sciences Research Council (EPSRC) funded project to evaluate manufacture through the Redistributed Manufacturing in Healthcare (RiHN) network. From these sources and a number of stakeholder meetings, a wide range of regulatory challenges have been identified with POC products that will be addressed in the new regulatory framework. |
URL | https://www.gov.uk/government/consultations/point-of-care-consultation/consultation-on-point-of-care... |
Description | Department of International Trade, Global Supply Chains Directorate - creation of supply chain capability development programme |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | Point of Care manufacture: creation of a new regulatory framework for medicinal products |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | Findings from RiHN and input from RiHN team members into the development of innovative regulation for point of care manufacturing by MHRA |
URL | https://www.eventbrite.co.uk/e/point-of-care-framework-workshops-registration-110265521142 |
Description | Westminster Health Forum |
Geographic Reach | National |
Policy Influence Type | Participation in a guidance/advisory committee |
Impact | Considered the future direction of procurement and commissioning practices in healthcare, and how systemic changes to the NHS such as the move to integrated care systems may impact the landscape going forward. |
URL | https://www.westminsterforumprojects.co.uk/publication/NHS-Procurement-2022 |
Description | A platform to investigate multi-tissue crosstalk mediated by exercise induced soluble factors released from human skeletal muscle |
Amount | £199,208 (GBP) |
Funding ID | NC/X001970/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start | 02/2023 |
End | 06/2024 |
Description | Accelerating the Medicines Revolutions Large Grant |
Amount | £2,000,000 (GBP) |
Funding ID | APP14087 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2024 |
End | 03/2026 |
Description | Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital (AIDPATH) |
Amount | € 9,860,991 (EUR) |
Funding ID | 101016909 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2021 |
End | 12/2024 |
Description | CHSS/CBL Collaborative Seed Fund 2024-25 |
Amount | £9,000 (GBP) |
Organisation | University of the West of England |
Sector | Academic/University |
Country | United Kingdom |
Start | 03/2024 |
End | 06/2025 |
Description | JOINT EXPERIMENTATION RESEARCH AND INNOVATION (JERI) |
Amount | £123,600 (GBP) |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 04/2023 |
Description | Redistributed Manufacturing in Healthcare: Establishing UWE as a Centre of Excellence |
Amount | £9,685 (GBP) |
Organisation | University of the West of England |
Sector | Academic/University |
Country | United Kingdom |
Start | 03/2022 |
End | 09/2022 |
Description | RiHN Feasibility Study - Proof-of-concept of long-term storage of functional extra-cellular vesicles for application in accelerated soft-tissue and fracture healing |
Amount | £15,645 (GBP) |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 10/2021 |
Title | File comprising the raw values used to create the figures present in the publication "Bioinspired Collagen/Hyaluronic Acid/Fibrin-Based Hydrogels for Soft Tissue Engineering: Design, Synthesis, and In Vitro Characterization" |
Description | The dataset submitted contains the raw analytical data, after being treated, used to create the graphs for the following analysis:Figure 2b - degree of Crosslinking obtained from the fluorescence measurements after a TNBS assay which assessed the amount of free amines in a molecule, in this case, collagen. Values were then reported as percentage of free amines. Figure 2c - Rheological data showing the viscoelastic properties of the produced hydrogel materials, depending on the ratio and concentration of crosslinker, PEG.Figure 2d - Rheological data showing the viscosity variation according to different shear rates to demonstrate how the material deforms and assess its suitability for bioprinting. Figure 3 - Rheological data showing the viscoelastic properties of the selected hydrogel formulation, CHAF_1, with time (a), upon different strains (deformation) (b), and stiffness (c).Figure 4b - data collected from the spectroscopy analysis (FTIR) on the raw materials and final hydrogel to study the molecular conformation.Figure 5b - Measurement of how much water is taken by the dry material, based on weight changes, converted into percentage.Figure 6b - Values of pore diameter obtained from manual measurement of pores from images obtained via scanning electron microscopy. Data is arranged as a distribution graph.Figure 6d - Measurement of how much weight is loss for the samples immersed in physiological conditions ( weight changes converted into percentage).Figure 7b - Fluorescence measurement of the data obtained from a presto blue assay, which studies the metabolic activity of the cell-seeded onto the hydrogel and control plastic.Figure 8a,b - Fluorescence measurement of the data obtained from a presto blue assay, which studies the metabolic activity of the cell-seeded into the hydrogel and control plastic.Figure 9b - Values obtained for the area of spheroids measured from micrographs taken with an optical microscope. Area monitored across 7 days.Figure 9d - Cell viability using a measurement of green fluorescence. |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
URL | https://data.ncl.ac.uk/articles/dataset/File_comprising_the_raw_values_used_to_create_the_figures_pr... |
Title | File comprising the raw values used to create the figures present in the publication "Bioinspired Collagen/Hyaluronic Acid/Fibrin-Based Hydrogels for Soft Tissue Engineering: Design, Synthesis, and In Vitro Characterization" |
Description | The dataset submitted contains the raw analytical data, after being treated, used to create the graphs for the following analysis:Figure 2b - degree of Crosslinking obtained from the fluorescence measurements after a TNBS assay which assessed the amount of free amines in a molecule, in this case, collagen. Values were then reported as percentage of free amines. Figure 2c - Rheological data showing the viscoelastic properties of the produced hydrogel materials, depending on the ratio and concentration of crosslinker, PEG.Figure 2d - Rheological data showing the viscosity variation according to different shear rates to demonstrate how the material deforms and assess its suitability for bioprinting. Figure 3 - Rheological data showing the viscoelastic properties of the selected hydrogel formulation, CHAF_1, with time (a), upon different strains (deformation) (b), and stiffness (c).Figure 4b - data collected from the spectroscopy analysis (FTIR) on the raw materials and final hydrogel to study the molecular conformation.Figure 5b - Measurement of how much water is taken by the dry material, based on weight changes, converted into percentage.Figure 6b - Values of pore diameter obtained from manual measurement of pores from images obtained via scanning electron microscopy. Data is arranged as a distribution graph.Figure 6d - Measurement of how much weight is loss for the samples immersed in physiological conditions ( weight changes converted into percentage).Figure 7b - Fluorescence measurement of the data obtained from a presto blue assay, which studies the metabolic activity of the cell-seeded onto the hydrogel and control plastic.Figure 8a,b - Fluorescence measurement of the data obtained from a presto blue assay, which studies the metabolic activity of the cell-seeded into the hydrogel and control plastic.Figure 9b - Values obtained for the area of spheroids measured from micrographs taken with an optical microscope. Area monitored across 7 days.Figure 9d - Cell viability using a measurement of green fluorescence. |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
URL | https://data.ncl.ac.uk/articles/dataset/File_comprising_the_raw_values_used_to_create_the_figures_pr... |
Title | Supplementary information files for Effect of printing parameters on microscale geometry for 3D printed lattice structures |
Description | Supplementary files for article Effect of printing parameters on microscale geometry for 3D printed lattice structures This study investigated the effect of manufacturing parameters on the manufacturing quality of material extrusion additive manufacturing (MEAM), specifically focusing on the microscale geometry of lattice structures built up by discrete extruded filaments. The manufacturing parameters extrusion height, printing speed and extrusion width were investigated. Square grid structures, which can be precisely characterized, were used to develop fundamental understanding that can be translated to more complicated structures in future investigations. Print paths were directly created as machine control code (GCode) using FullControl GCode Designer, bypassing the conventional multi-stage translation of a design from CAD to an STL file, to slicing software and finally to GCode. This allowed precise parametric control of all aspects of the manufacturing procedure, including aspects that would not be possible with conventional slicing software such as control over the specific order and direction of printing each line, and the offsetting of specific printed lines on each layer in the Z direction by half the layer height. The printing quality of the structures was investigated with optical microscope and X-ray micro-computed tomography (micro-CT). Microscale changes to the extruded-filament geometry were characterized before and after filament-crossing points in the square grid structure, and internal cavities were identified. Printing speed was found to be a crucial parameter that should be carefully considered for lattice structure applications that require high manufacturing quality in terms of minimizing microscale geometric defects. Offsetting crossing extrudates by half the layer-height in the Z direction resulted in more consistent microscale geometry and greatly improved quality. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
URL | https://repository.lboro.ac.uk/articles/dataset/Supplementary_information_files_for_Effect_of_printi... |
Description | Centillion Technology |
Organisation | Centillion Technology |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provided sharing of updates and insights from the research programme. Facilitated their involvement in a pharma RDM feasibility study |
Collaborator Contribution | Sharing of RiHN feasibility study funding competition amongst their network Staff support and representation at programme meetings Offer to provide access to equipment and materials for the relevant pharma feasibility study team Offer to participate in meetings, workshops and events |
Impact | Pharmaceuticals manufacturing |
Start Year | 2020 |
Description | Centre for Process Innovation |
Organisation | Centre for Process Innovation (CPI) |
Country | United Kingdom |
Sector | Private |
PI Contribution | Sharing of progress on the research programme, details of feasibility studies and exploration of alignment and collaboration. |
Collaborator Contribution | Sharing of RiHN feasibility study funding competition amongst their network Offer to run innovation clinics for all feasibility study teams Offer to link CPI staff to relevant feasibility study teams to explore collaborative opportunities Offer to support feasibility study team with follow-on technology-development bids as a partner organisation |
Impact | Additive manufacturing Cell and tissue therapies Clinical fluids Pharmaceuticals |
Start Year | 2020 |
Description | Dstl - Project Mentor for RiHN funded feasibility study led by Keele University |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Facilitated Dstl co-funding and commitment to support the feasibility study with a dedicate project mentor Entered into a contract with Dstl for this purpose. |
Collaborator Contribution | Dedicated technical research advice and guidance Facilitated access to related researchers involved in military and emergency medicine Sharing of past knowledge and research in this area |
Impact | Cell and tissue therapies Regenerative medicine Advanced manufacturing |
Start Year | 2021 |
Description | Harwell Campus and STFC |
Organisation | Research Complex at Harwell |
Country | United Kingdom |
Sector | Public |
PI Contribution | Provided updates and insights from the programme. Also explored opportunities for co-funding |
Collaborator Contribution | Sharing of RiHN feasibility study funding competition amongst their network Offer to connect their organisations on-site to feasibility study teams Offer to facilitate support for feasibility study teams seeking to test their propositions using Harwell facilities |
Impact | Advanced manufacturing Cross-sector innovation SME innovation Spin outs |
Start Year | 2020 |
Description | Industry Partner |
Organisation | Porton Biopharma LTD |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provided information on latest advances in RDM |
Collaborator Contribution | Involved in reviewing documents and mentoring feasibility studies |
Impact | No outputs as yet |
Start Year | 2020 |
Description | MOD Defence Equipment and Support |
Organisation | Ministry of Defence (MOD) |
Department | Defence Equipment and Support |
Country | United Kingdom |
Sector | Public |
PI Contribution | Provided an introduction to the programme to various parts of the DE&S organisation involved in advancing the local production agenda (i.e. additive manufacturing) Sharing of insights and findings so far and discussion of mutual objectives |
Collaborator Contribution | Provided expertise and awareness of the value of RiHN research to MOD and DE&S Offer to conduct some joint-analysis activities to inform the business case for innovation adoption Offer to open doors relevant communities in defence working in the same area to compare approaches and avoid duplication |
Impact | Defence Acquisition Supply chain management Military and emergency medicine Defence innovation |
Start Year | 2020 |
Description | Medilink East Midlands |
Organisation | East Midlands Medilink |
Country | United Kingdom |
Sector | Private |
PI Contribution | RiHN ran a Special Interest Group on redistributed manufacturing for East Midlands Medilinks members presenting the RiHn feasibility studies and running a workshop on value chain mapping |
Collaborator Contribution | Medilinks have promoted the work of RiHN via its website and social media and hosted the Special Interest Group where RiHN launched the feasibility studies |
Impact | Supply Chain Special Interest Group |
Start Year | 2015 |
Description | R&D, James Cook University Hospital |
Organisation | James Cook University Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Sharing of progress for the research programme and discussion of collaborative opportunities |
Collaborator Contribution | Sharing of RiHN feasibility study funding competition amongst their network Research linkages to CPI Offer to use a bio-incubator on-site for feasibility study teams Offer to provide an NHS test-bed for feasibility study teams Linking up and networking to colleagues in MoD via their partnership |
Impact | Medical innovation |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Centillion Technology Systems (CTS) |
Country | Australia |
Sector | Private |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Centre for Process Innovation (CPI) |
Country | United Kingdom |
Sector | Private |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Defence Medical Services |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Country | United Kingdom |
Sector | Public |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Innovate UK |
Country | United Kingdom |
Sector | Public |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Ministry of Defence (MOD) |
Department | Defence Equipment and Support |
Country | United Kingdom |
Sector | Public |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Quay Pharma |
Country | United Kingdom |
Sector | Private |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | RiHN Network Plus Advisory Board 2020-2022 |
Organisation | Research Complex at Harwell |
Country | United Kingdom |
Sector | Public |
PI Contribution | The research team delivered presentations and thought leadership as well as updates and insights from the research programme. |
Collaborator Contribution | Delivered expert advice and guidance on current developments in industry, academia and public sector innovation. This included access to networks, |
Impact | - Collaboration with feasibility study teams - Access to experts - Access to reports and data |
Start Year | 2020 |
Description | Scitech |
Organisation | Scitech Engineering Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provided updates and insights from the research programme |
Collaborator Contribution | Sharing of RiHN feasibility study funding competition amongst their network Offer to provide technical mentioring for any relevant pharma feasibility study teams Offer to provide a cost of goods analysis for feasibility study teams or the programme Offer to provide a validation engineering analysis for the programme Offer to use meeting and conference facilities on-site |
Impact | Pharmaceuticals Manufacturing |
Start Year | 2020 |
Description | Blog by Dr Andrew Capel - my story on why Rehabilitation Matters |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Blog highlighting how ever-advancing technology is increasing the potential scope of research - and rehabilitation iand UK is one of the leading countries undertaking research in this area |
Year(s) Of Engagement Activity | 2022 |
URL | https://nationalrehabilitationcentre.nhs.uk/latest-news/rehabilitation-matters/1623-dr-andrew-capel-... |
Description | Blood Manufacturing Value Stream Mapping Introduction |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | A workshop led by John Kiff to introduce Flt. Lt. Dr. Felix Wood to an engineering management methodology value stream mapping to be able to apply it to a healthcare scenario and articulate key metrics or parameters for a unspecialised audience. |
Year(s) Of Engagement Activity | 2022 |
Description | Businesss Insider (Sept 21st, 2020) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Discusses the rollout of a COVID-19 vaccine. Includes interview with Dr Sam Roscoe, Co-I on RDM in Deployed Operations Network Plus and also draws on findings on the research undertook for RiHN |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.businessinsider.com/covid-19-vaccine-experts-warn-glass-vials-planes-storage-shortage-20... |
Description | CLOSER, BETTER, LONGER: DMS-DSTL BLOOD SYMPOSIUM |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Around 150 experst and practitioners in the filed of blood products discussed blood requirements for defence |
Year(s) Of Engagement Activity | 2023 |
Description | Chemistry World (Oct 15th, 2020) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Article discussing resilience and redundancy as key factors for domestic manufacturing. Includes interview with Dr Sam Roscoe, Co-I on RDM in Deployed Operations network Plus |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.chemistryworld.com/news/covid-19-highlights-need-to-update-pharma-supply-chains/4012597.... |
Description | Clinical Fluids Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Workshop with members of the RiHN funded clinical fluids project, the researcher, industrial collaborators, defence clinician, and end-user collaborators. Discussion and remapping on the value stream map and hypothetical scenario for clinical fluid resupply. Information provided by all parties to refine and improve the understanding of the proposed future state that the impact that the technology will have. |
Year(s) Of Engagement Activity | 2022 |
Description | Conference Attendance: Regenerative Medicine on the Front Line (Stakeholder Collaboration Day) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Represented RiHN at the Defense and Security Accelerator (DASA) stakeholder collaboration day, which aimed to encourage collaborative projects in the field of regenerative medicine in the deployed healthcare. Networked with, and established new contacts/collaborators from both Defense Medical Services and the academic R&D sector. |
Year(s) Of Engagement Activity | 2021 |
Description | Conference presentation at EurOMA 2022: "Brilliance in resilience: operations and supply chain management's role in achieving a sustainable future" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Research examining the role of end user insight in the development of operational requirements for deployed healthcare was presented to academic peers for feedback and critical insight, at a EurOMA conference session focused on digital innovation in the humanitarian sector (~30 participants). The presentation generated discussion about the utility and relevance of end user engagement in healthcare innovation and new international connections were cemented. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.euroma2022.org/ |
Description | Conference presentation at EurOMA 2022: "Humanitarian Innovation: Defining The Operational Requirements For Deployed Healthcare" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research examining the role of end user insight in the development of operational requirements for deployed healthcare was presented to academic peers for feedback and critical insight, at a EurOMA conference session focused on digital innovation in the humanitarian sector (~30 participants). The presentation generated discussion about the utility and relevance of end user engagement in healthcare innovation and new international connections were cemented |
Year(s) Of Engagement Activity | 2022 |
URL | https://uwe.worktribe.com/record.jx?recordid=9719954 |
Description | Conference presentation at EurOMA 2022: "Innovation in healthcare: developing the business case for redistributed manufacturing in deployed medical operations " |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of conference paper examining the role of value stream mapping for deployed healthcare was presented to academic peers for feedback and critical insight, at a EurOMA conference session focused on innovation in healthcare (~30 participants). The presentation generated discussion about the utility and relevance of end user engagement in healthcare innovation, transferring operational management practice into medical process flows, and developing new international connections. |
Year(s) Of Engagement Activity | 2022 |
URL | https://uwe.worktribe.com/record.jx?recordid=9720006 |
Description | Conference presentation at ISPIM 2022: "Innovation in deployed medical care: Building resilient healthcare supply chains" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research examining the role of end user insight in the technology roadmapping of deployable medical technologies was presented to academic peers for feedback and critical insight, at an IPSIM conference session focused on digital innovation in the healthcare sector (~30 participants). The presentation generated discussion about the utility and relevance of end user engagement in healthcare innovation, and new international connections were made. |
Year(s) Of Engagement Activity | 2022 |
URL | https://uwe.worktribe.com/record.jx?recordid=10488744 |
Description | Conference presentation at POMS 2022: "Redistributed Manufacturing in Healthcare: Developing the Business Case for Innovation" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | PhD student Victor Uwalaka's presentation of conference paper examining the role of value stream mapping for deployed healthcare was presented to academic peers for feedback and critical insight, at a EurOMA conference session focused on innovation in healthcare (~30 participants). The presentation generated discussion about the utility and relevance of end user engagement in healthcare innovation, transferring operational management practice into medical process flows, and developing new international connections |
Year(s) Of Engagement Activity | 2022 |
URL | https://pomsmeetings.org/conf-2022/ |
Description | Daily Telegraph- Business Reporter (March 25th, 2020) Future of Supply Chain / How Coronavirus is disrupting key supply chains when we need them the most |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Article by Dr Sam Roscoe in The Telegraph (Business Reporter on how Coronavirus is disrupting key supply chains when we need them the most. Dr Roscoe is a CO-I on the RDM in Deployed Operations Network Plus and his discussion is informed by research he undertook for RiHN |
Year(s) Of Engagement Activity | 2020 |
URL | https://business-reporter.co.uk/2020/03/25/how-coronavirus-is-disrupting-key-supply-chains-when-we-n... |
Description | Defence Military Services - RiHN Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | Defence Medical Services (DMS) invited 30 members of personnel from all 3 service branches of the armed forces to discuss where redistributed manufacturing could contribute to addressing their needs in a deployed medical operating environment. The outcome of this work revealed several defence priority areas which were identified and raised in a final report summary given to the head of DMS. |
Year(s) Of Engagement Activity | 2023 |
Description | Defence Military Services Innovation Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Present the potential role of RDM in supporting the delivery of Deployed medical care for the military and to present the work of the RiHN |
Year(s) Of Engagement Activity | 2022 |
Description | Delaware Consulting Research insight report (July 7th, 2020) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Report that considers "Innovation driven by necessity -Why flexibility and transformation are key for manufacturers to deliver in uncertain times". Dr Sam Roscoe Co-I on RDM in Deployed Operations Network Plus provided the Preface for the Research Insight Report |
Year(s) Of Engagement Activity | 2020 |
URL | https://info.delaware.pro/innovation-research-insight-report?__hstc=221351303.7457f258f6de201cae1c43... |
Description | Deployed Medical and Healthcare Delivery 2022 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Conference - Deployed Medical and Healthcare Delivery. A networking opportunity for RiHN to meet and interact with Defence Medical Services and other healthcare related personnel. Contacts with JHUB Med were established at this meeting. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.defenceiq.com/events-deployedmedicalforum |
Description | Deployed Medical and Healthcare Delivery 2023 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Conference - Deployed Medical and Healthcare Delivery. A networking opportunity for RiHN to meet and interact with Defence Medical Services and other healthcare related personnel. Working with DSTL and Stratcom to develop the value stream mapping for blood manufacturing project. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.defenceiq.com/events-deployedmedicalforum |
Description | Design 4 Additive Manufacturing - RiHN |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentations from RiHN Co-Is as well as workshops faciliated by RiHN team members to bring together academics in additive layer manufacturing and innovation to develop understanding around how the new technology can be used in emerging fields such as clinical environments and pharmaceuticals. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.d4am.eng.cam.ac.uk/research/d4am-project |
Description | European Pharmaceutical review (April 8th, 2020): Limiting shortages: steps for the UK to strengthen drug supply. |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Dr Sam Roscoe, Co-I on RDM in Deployed Operations, explains his recommendations for pharmaceutical companies and supermarkets in the UK to limit reliance on deliveries from overseas, to ease the impact of the COVID-19 coronavirus on drug supply chains. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.europeanpharmaceuticalreview.com/article/116439/limiting-shortages-steps-for-the-uk-to-s... |
Description | Focus Group Workshop (Field-Testing) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | 14 stakeholders (sector coverage: R&D scientists/innovators/entrepreneurs, military and humanitarian 'lead user' representatives, academics/innovation managers) joined a workshop event to examine the potential for developing field-testing opportunities to support the development of R&D innovations targeting the deployed healthcare sector. The purpose was to discuss: - What could field-testing look like? - What are the challenges/barriers, opportunities? - How can we shape a collaborative bid to develop field-testing opportunities? Expert insight from these discussions will help inform and shape a collaborative grant proposal to develop field-testing opportunities for deployed healthcare innovators, and to connect and partner them with lead users and organsations with experience of working in austere deployed environments. |
Year(s) Of Engagement Activity | 2021 |
Description | Global Value Chain Reconfiguration and COVID-19 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | YouTube video created by california Management review to promote the findings of our research snd based on the article: "Global Value Chain Reconfiguration and COVID-19: Investigating the Case for More Resilient Redistributed Models of Production" by Wendy Phillips, Jens K. Roehrich, Dharm Kapletia, and Elizabeth Alexander The video has sparked furthe rinterest in our the Network and its research and as a result we have been approached by individuals and organisations who are interested in knowing more about our work |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.youtube.com/watch?v=qDPVKr-dXiE |
Description | Higher Education Innovation Fund Workshop Event 2022 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | HEIF workshop event, involved talks from regional institutions with an interest of RDM for healthcare and how they could align with RiHN. Presentations from Corryn Biotechnologies, WEAHSN, NCC, and RiHN. Later workshop event around establishing the South West as centre of excellence for redistributed manufacturing. |
Year(s) Of Engagement Activity | 2022 |
Description | Innovate UK Workshop: Simplified Delivery of Complex Medicines |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Workshop irganised by Innovate UK's Transforming Medicines Manufacturing (TMM) Programme which aims to support the development, de-risking and commercialisation of transformative innovation in medicines process development and manufacturing. The workshop drew together around 50 experts with experience and knowledge in NHS supply chains to contribute towards the designing of a programme which will be relevant to sector needs. During the workshop, participants were asked to scope and define a competition in the space of "Simplified Delivery of Complex Medicines", with the objective of addressing challenges associated with administering complex medicines by needle-free methods. Discussion points included: • Are we there yet? What are the translational challenges which need to be addressed prior to reaching the point of manufacturing. • What are the development and manufacturing challenges associated with the formulation of complex medicines? • How do we improve the properties of the delivery vehicles thereby enabling simpler methods of delivery? |
Year(s) Of Engagement Activity | 2023 |
Description | Interview/comment for international news outlet CNBC |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | RiHN co-investigator Dr Sam Roscoe provided expert opinion on the 2021 gas crisis - highlighting the ripple effects of Brexit on the UK labour market and supply chains. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.cnbc.com/2021/10/18/gas-crisis-labor-shortages-and-supply-chain-chaos-post-brexit-britai... |
Description | Interview/comment for online news outlet Tech Monitor |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | RiHN CoI Dr Sam Roscoe provided expert opinion for an article discussing "Can digital technology prevent supply chain disruptions?", where he highlighted the impact of political intervention upon global supply chains. |
Year(s) Of Engagement Activity | 2021 |
URL | https://techmonitor.ai/leadership/strategy/can-digital-technology-prevent-supply-chain-disruptions#:... |
Description | JHubMed - RiHN AM OPCP Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A visit to JHubMed to discuss and outline some of the operating patient care pathway and where re-distributed manufacturing and additive layer manufacturing can make an impact and improve end-user delivery of care. |
Year(s) Of Engagement Activity | 2022 |
Description | LSE Business Review (May 19th, 2020) The future of UK supply chains in a disrupted world: Brexit and Covid-19 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Dr Sam roscoe, Co-I on RDM in Deployed operations bid discusses the future of UK supply chains in a disrupted world: Brexit and Covid-19 |
Year(s) Of Engagement Activity | 2020 |
URL | https://blogs.lse.ac.uk/businessreview/2020/05/19/the-future-of-uk-supply-chains-in-a-disrupted-worl... |
Description | Lombard (Oct, 2020) Reshoring: the key to manufacturing reslience? |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Report on the pros and cons of shaking up their supply chains. Includes interview with Dr Sam Roscoe, Co-I on RDM in Deployed Operations |
Year(s) Of Engagement Activity | 2020 |
URL | https://lombard.contentlive.co.uk/content/reshoring-the-key-to-manufacturing-resilience |
Description | Medical Logistics Workshop - RiHN |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | A visit from the 84th Medical Logisitics Sqn. to UWE Bristol campus to discuss value stream mapping, technology innovation feasibility projects being developed by RiHN co-collaborators, and sharing of defence deployed operating scenarios and workflows. |
Year(s) Of Engagement Activity | 2022 |
Description | Meet the Guest Editors of the IJOPM Special Issue |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | 32 academics attended a workshop for a Special Issue of the International Journal of Operations and Production Management on "Emerging Technologies in Emergency Situations" f This special issue invites scholars and practitioners to provide insights and contributions to the Operations and Supply Chain Management (O&SCM) field by considering the integration of emerging technologies for emergency situations. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.eventbrite.co.uk/e/112789313874 |
Description | Pharmaceutial Journal (May 6th, 2020) Manufacturer to move hydroxycholorquine production to the UK to avoid shortages |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Reports on Dr Sam Roscoe, Co-I on RDM in Deployed Operations Network Plus address to the House of Commons International Trade Committee on 23 April 2020, His discussion builds on his findings from his RiHN funded research |
Year(s) Of Engagement Activity | 2020 |
URL | https://pharmaceutical-journal.com/article/news/manufacturer-to-move-hydroxychloroquine-production-t... |
Description | Podcast Industry Dive - Dec 17th, 2020 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Podacst Industry Dive - Dec 17th, 2020 - Money Minutes in partnership with American Express - Futureproofing your supply chain against costly disruptions. Dr Sam Roscoe - RDM in Deployed Operations is interviewed |
Year(s) Of Engagement Activity | 2020 |
URL | https://omny.fm/shows/business-class-money-minutes/futureproofing-your-supply-chain-against-costly-d... |
Description | Point of Care Framework Meeting: 18.03.21 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Medicines and Healthcare products regulatory Agency (MHRA) Point of Care Framework Meeting which followed up on the two workshops held in 2020 to develop a new regulatory framework for Point of Care (PoC) manufacturing of medicinal products. Developing a new regulatory framework for PoC manufacture is one of the 'innovative regulation' projects in the second Sector Deal of the UK's Life Sciences Industrial Strategy. High level regulatory proposals were presented at this meeting for the new UK regulatory framework which will enable the safe development of this new pharmaceutical sector. At this meeting, participants contributed to: • The proposals for a new regulatory framework which will enable the safe development of this new sector of pharmaceutical manufacture in the UK. • The next stages of the work which will lead to the new regulatory framework. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.eventbrite.co.uk/e/point-of-care-framework-meeting-tickets-143037205131?utm_source=Gov%2... |
Description | RDM Working Group for the Defence Medical Services. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Members of the RiHN research team have been ivited by JHUBMED, the medical innovation group of MoD, to sit on a working group focused on Redistributed Manufacturing in defence medical services |
Year(s) Of Engagement Activity | 2024 |
Description | Raconteur Magazine (Sept 30th, 2020) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Article in Raconteur Magazine (Sept 30th, 2020) Could reshoring help manufacturers survive COVID? Includes interview with Dr Sam Roscoe, Co-I on RDm in Deployed Operations Network Plus |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.raconteur.net/supply-chain/reshoring-manufacturing-covid/ |
Description | Research to assess possibility of producing healthcare products like PPE at point of need |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Press release from UWE promoting the RiHN Deployed Operations Programme |
Year(s) Of Engagement Activity | 2020 |
Description | Resilient Healthcare in Supply Chains |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | A podcast for Chain Reaction which is a podcast 'All About Supply Chain Advantage' containing regular audio snippets relevant to C suite executives, supply chain professionals, researchers, policy makers in government, students, media commentators and the wider public. New episodes each week discuss hot topics in the news and supply chain ideas relevant to everyone involved in supply chain management. In the episode Prof Wendy Phillips (PI) discusses resilient supply chains in healthcarefocusing on how redistributed manufacturing as a strategy can be used to improve timeliness to meet patient needs better. |
Year(s) Of Engagement Activity | 2022 |
URL | https://podcasts.apple.com/gb/podcast/resilient-supply-chains-in-healthcare-extract/id1552626101?i=1... |
Description | RiHN Final Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presnt the final report and findings to experts and practitioners with an interest in rDm and to collatethe impact of the RiHN programme |
Year(s) Of Engagement Activity | 2023 |
Description | RiHN Funding Webinar |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RiHN held its first funding webinar on the 17th September 2020 with +70 participants attending. The participants represented over 27 different higher education organisations and a few industry/public sector members. We aimed to provide potential applicants with an overview of the funding competition and an opportunity to ask questions about the research themes and application process. We invited UK researchers to actively engage with us, learn more about our aims and how we are collaborating with stakeholders in the deployed medical care ecosystem. The outcome of this webinar was a high request for application documentation, building on our RiHN membership base to 250 members and later on, we received 22 applications from attendees. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.eventbrite.co.uk/e/rihn-research-funding-qa-webinar-tickets-117407211129# |
Description | RiHN+ Final Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Final event for the the RDM in Deployed Medical Care Network+ where the final report was presented to interested parties from defence medical care, NHS, industry and academia. It stimulated further engagement activities and participation in MoD working groups related to redistribiuted manufacturing and additive manufacturing |
Year(s) Of Engagement Activity | 2023 |
Description | Special Interest Group: Point-of-Care Manufacturing 1 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RiHN is hosting an online event to discuss the business case for point-of-care redistributed manufacturing (RDM) focussing on additive layer manufacturing and pharmaceutical manufacturing. Talks from Dr. Phil Reeves, Dr. Luke Burke around the benefits of PoC additive manufacturing, and Dr. Sam Roscoe and Prof. Sheng Qi around redistributed manufacturing of pharmaceuticals With senior stakeholders in RDM on the steering panel for this special interest group, their involvement lends weight to |
Year(s) Of Engagement Activity | 2021 |
URL | https://rihn.org.uk/sig/ |
Description | Special Interest Group: Point-of-Care Manufacturing 2 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RiHN is hosting online a series of short talks on the business case for redistributed manufacturing (RDM) in clinical fluid, and cell & tissue manufacturing. Talks from Prof. Nick Medcalf - Innovate UK and Dr. Ifty Ahmed - University of Nottingham, on Cell & Tissue Manufacturing at the point-of-care. Followed by talks from Prof. Darren Reynolds and Dr. Jenni May, on clinical fluid manufacturing and the challenges facing blood transfusion for frontline treatment. With senior stakeholders in RDM on the steering panel for this special interest group, their involvement lends weight to the conversation and depth to what "point-of-care" manufacturing means to them. We hope to tackle some of the unique challenges in implementing and validating RDM solutions, determine where in the economic model does RDM makes the most sense, and articulate the benefits to both the providers and end-users. |
Year(s) Of Engagement Activity | 2022 |
URL | https://rihn.org.uk/sig/ |
Description | Special Interest Group: Point-of-Care Manufacturing 3 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RiHN is meeting in person to debate on the business case for redistributed manufacturing (RDM) in clinical fluid, and cell & tissue manufacturing. Talks from Prof. Bill Scott - Newcastle University, Lt. Col. Dr. Paul Hunt - DMS, Prof Richard Bibb - Loughborough University. With senior stakeholders in RDM on the steering panel for this special interest group, their involvement lends weight to the conversation and depth to what "point-of-care" manufacturing means to them. We hope to tackle some of the unique challenges in implementing and validating RDM solutions, determine where in the economic model does RDM makes the most sense, and articulate the benefits to both the providers and end-users. Part of the workshop will be part of a technology roadmapping exercise we hope to contribute to ALM business case to adopt RDM for healthcare and where it can make an impact. Being able to meet in-person allows us to showcase facilities of partner organisations such as the centre for process innovation (CPI), home of the national biologics manufacturing centre and the RNA centre of excellence. CPI will be hosting tours of both facilities and an opportunity to meet with some the technologists. |
Year(s) Of Engagement Activity | 2022 |
URL | https://rihn.org.uk/sig/ |
Description | Stakeholder engagement with Ministry of Defence staff involved in procurement, support, innovation and military medicine |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Shared insights and documents from our research programme to help advance the advanced manufacturing innovation adoption agenda within the Ministry of Defence. Also sought to establish research collaboration opportunities for the programme and our funded feasibility studies, facilitating linkages between our respective teams. This will also lead to joint-analysis and opportunities for shaping funding strategies. |
Year(s) Of Engagement Activity | 2020,2021 |
Description | The Future Factory (February 24th, 2020) |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Blog by Dr Sam roscoe, Co-I on RDM in Deployed Operations Network Plus on Supply Chain 4.0 and how emerging technologies are reconfiguring global supply chains. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.thefuturefactory.com/blog/41 |
Description | The Guardian (May 10th, 2020) Drug manufacturing must be brought to UK, NHS bosses and charities tell MPs |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Article in The Guardian where Dr Sam Roscoe,Co-I of RDM in Deployed Operations, building on findings of a feasibility study funded by RiHN Academics calls a "major structural change in supply chains". |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.theguardian.com/business/2020/may/10/bring-drug-manufacturing-to-uk-nhs-mps?CMP=Share_iO... |
Description | Tidal N+ and RiHN Workshop Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Event promoting Tidal N+ funding call for Digital Manufacturing Systems and Physical Devices. Paul Hunt, Wendy Phillips and Chris Howell gave presentations online around RDM and technology research themes relevant to TidalN+ . The event led to identifying opportunities, research questions, and challenges based on mapping workshops with public stakeholders, end-users, regulators, innovation implementers, and technology developers. |
Year(s) Of Engagement Activity | 2022 |
Description | UK Trade Policy Observatory (March 24th, 2020) |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Guest blog by Dr Sam Roscoe On Covid-19 Supply Chain Issues |
Year(s) Of Engagement Activity | 2020 |
URL | https://blogs.sussex.ac.uk/uktpo/2020/03/24/covid-19-and-two-key-supply-chains/ |
Description | • Reconfiguring healthcare supply chains: the scope, challenges and opportunities. Presentation to Performance with Purpose Research Centre, London Met, 17 Jan 2024 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Presentation to staff and PG students asscoaciated with Purpose Research Centre, London Metrolpolitan University presenting the key finsings of the RiHN research. |
Year(s) Of Engagement Activity | 2024 |