Characterisation of Nano-Particulates in Natural Systems
Lead Research Organisation:
University of Leeds
Department Name: Institute of Materials Research
Abstract
Characterisation of the primary nano-particulate crystallites that make up natural and synthetic structures is of increasing importance in industrial, biological and environmental application. This Advanced Fellowship aims to build on existing studies by the applicant, his collaborators, and his PhD students, and will focus on the determination of the surface characteristics that appear to differentiate nano-particle minerals in natural systems (environmental and biological) from those in synthetic systems. In particular the underlying hypothesis is that dynamic exchangeable (or thermodynamically unstable) surfaces are a consistent feature of primary particles in natural systems that then shape the physical characteristics at the macroscopic level, in particular explaining aspects of exchangeability, turnover, mechanical strength and interaction with organic molecules. The application draws on the latest analytical electron microscopy techniques available in the physical sciences and, with novel application, applies them to the environments of natural systems which are very sensitive to electron beam irradiation. This leading edge structural analysis will provide fundamental data that will then be used to probe the function of the particle in the system. Therefore the application truly serves to advance potential understanding and cross-disciplinary interaction.
People |
ORCID iD |
Andrew Brown (Principal Investigator) |
Publications
Hondow N
(2011)
STEM mode in the SEM: a practical tool for nanotoxicology.
in Nanotoxicology
Li X
(2011)
Low-Temperature Preparation of Single Crystal Titanium Carbide Nanofibers in Molten Salts
in Crystal Growth & Design
Whittleston RA
(2011)
Chromate reduction in Fe(II)-containing soil affected by hyperalkaline leachate from chromite ore processing residue.
in Journal of hazardous materials
Bonneville S
(2011)
Tree-mycorrhiza symbiosis accelerate mineral weathering: Evidences from nanometer-scale elemental fluxes at the hypha-mineral interface
in Geochimica et Cosmochimica Acta
Bilton M
(2012)
Comparison of Hydrothermal and Sol-Gel Synthesis of Nano-Particulate Hydroxyapatite by Characterisation at the Bulk and Particle Level
in Open Journal of Inorganic Non-metallic Materials
Singh N
(2012)
The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.
in Biomaterials
Vaughan G
(2012)
Characterisation of Synthetic Two-line Ferrihydrite by Electron Energy Loss Spectroscopy
in Journal of Physics: Conference Series
Booth M
(2012)
Determining the Concentration of CuInS 2 Quantum Dots from the Size-Dependent Molar Extinction Coefficient
in Chemistry of Materials
Wallace R
(2012)
Characterisation of ZnO nanoparticle suspensions for toxicological applications
in Journal of Physics: Conference Series
Mu Q
(2012)
Mechanism of cellular uptake of genotoxic silica nanoparticles.
in Particle and fibre toxicology
Burke IT
(2012)
Speciation of arsenic, chromium, and vanadium in red mud samples from the Ajka spill site, Hungary.
in Environmental science & technology
Hondow N
(2012)
Quantitative characterization of nanoparticle agglomeration within biological media
in Journal of Nanoparticle Research
Raza M
(2012)
Performance of graphite nanoplatelet/silicone composites as thermal interface adhesives
in Journal of Materials Science: Materials in Electronics
Raza M
(2012)
Texture, transport and mechanical properties of graphite nanoplatelet/silicone composites produced by three roll mill
in Composites Science and Technology
Raza MA
(2012)
Graphite nanoplatelets produced by oxidation and thermal exfoliation of graphite and electrical conductivities of their epoxy composites.
in Journal of nanoscience and nanotechnology
Rozita Y
(2013)
A Study of Commercial Nanoparticulate ?-Al 2 O 3 Catalyst Supports
in ChemCatChem
Churchman AH
(2013)
Serum albumin enhances the membrane activity of ZnO nanoparticles.
in Chemical communications (Cambridge, England)
Pan Y
(2013)
Quantification of absolute iron content in mineral cores of cytosolic ferritin molecules in human liver
in Materials Science and Technology
Vallina B
(2013)
Amorphous dysprosium carbonate: characterization, stability, and crystallization pathways
in Journal of Nanoparticle Research
Wallace R
(2013)
Synthesis of ZnO nanoparticles by flame spray pyrolysis and characterisation protocol
in Journal of Materials Science
Ward MB
(2013)
Investigating the role of microbes in mineral weathering: nanometre-scale characterisation of the cell-mineral interface using FIB and TEM.
in Micron (Oxford, England : 1993)
Jugdaohsingh R
(2013)
High-aluminum-affinity silica is a nanoparticle that seeds secondary aluminosilicate formation.
in PloS one
Pereira DI
(2013)
Caco-2 cell acquisition of dietary iron(III) invokes a nanoparticulate endocytic pathway.
in PloS one
Brown A
(2013)
Nanomedicine
Description | I have developed methods to characterise nanoparticles in natural environments such as cells and frozen fluids by electron microscopy. Thus we can explore the structure and chemistry of these particles to explore how these environments might affect the particles' properties. |
Exploitation Route | I have progressed to a full academic in this area of electron microscopy. Others will use the microscopy techniques developed in this work for similar nano particle, nano toxicology and nano medicine investigations. |
Sectors | Chemicals,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |