Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Štarha P
(2016)
Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes.
in Inorganic chemistry
Zou T
(2015)
Speciation of precious metal anti-cancer complexes by NMR spectroscopy.
in Drug discovery today. Technologies
Zhang X
(2019)
Glutathione activation of an organometallic half-sandwich anticancer drug candidate by ligand attack.
in Chemical communications (Cambridge, England)
Zhang WY
(2020)
Ligand-centred redox activation of inert organoiridium anticancer catalysts.
in Chemical science
Zhang P
(2017)
Redox-Active Metal Complexes for Anticancer Therapy
in European Journal of Inorganic Chemistry
Zhang P
(2017)
Advances in the design of organometallic anticancer complexes
in Journal of Organometallic Chemistry
Xue X
(2021)
Photoactivated Osmium Arene Anticancer Complexes.
in Inorganic chemistry
Xie MJ
(2017)
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV.
in Journal of inorganic biochemistry
Wu Q
(2018)
Rigid dinuclear ruthenium-arene complexes showing strong DNA interactions.
in Journal of inorganic biochemistry
Wootton CA
(2019)
Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation.
in The Analyst
Wootton CA
(2015)
Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry.
in Dalton transactions (Cambridge, England : 2003)
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Wilson N
(2013)
Weak mismatch epitaxy and structural Feedback in graphene growth on copper foil
in Nano Research
Wilson N
(2010)
On the structure and topography of free-standing chemically modified graphene
in New Journal of Physics
Wills RH
(2012)
Structural characterization of polyketides using high mass accuracy tandem mass spectrometry.
in Analytical chemistry
Wills RH
(2014)
Structural characterization of actinomycin D using multiple ion isolation and electron induced dissociation.
in Journal of the American Society for Mass Spectrometry
Wills R
(2014)
Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry
in Journal of the American Society for Mass Spectrometry
Wei J
(2014)
D-a-tocopheryl polyethylene glycol 1000 succinate: a view from FTICR MS and tandem MS.
in Analytical chemistry
Wei J
(2015)
Extensive fragmentation of pheophytin-a by infrared multiphoton dissociation tandem mass spectrometry.
in Rapid communications in mass spectrometry : RCM
Wei J
(2013)
Structural characterization of chlorophyll-a by high resolution tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Wei J
(2015)
The Competitive influence of Li+, Na+, K+, Ag+, and H+ on the fragmentation of a PEGylated polymeric excipient.
in Journal of the American Society for Mass Spectrometry
Wang Y
(2016)
Nanoparticles of chitosan conjugated to organo-ruthenium complexes
in Inorganic Chemistry Frontiers
Wang FX
(2022)
Reactions of cisplatin and oxaliplatin with penicillin G: implications for drug inactivation and biological activity.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Venkatesh V
(2017)
Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes.
in Chemical science
Vallotto C
(2018)
Photoactivatable platinum anticancer complex can generate tryptophan radicals.
in Chemical communications (Cambridge, England)
Sun L
(2014)
Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation.
in Nature communications
Sriskandakumar T
(2015)
Electrophilic Activation of Oxidized Sulfur Ligands and Implications for the Biological Activity of Ruthenium(II) Arene Anticancer Complexes.
in Inorganic chemistry
Spencer J
(2016)
Coherence lifetime broadened optical transitions in a 2 atom diameter HgTe nanowire: a temperature dependent resonance Raman study
in RSC Advances
Soldevila-Barreda JJ
(2015)
Approaches to the design of catalytic metallodrugs.
in Current opinion in chemical biology
Soldevila-Barreda JJ
(2015)
Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design.
in Nature communications
Smith NA
(2017)
Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.
in Chemical science
Smith N
(2017)
Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes
in Inorganica Chimica Acta
Smith DC
(2016)
Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems.
in Journal of visualized experiments : JoVE
Sink A
(2022)
Kinetics and mechanism of sequential ring methyl C-H activation in cyclopentadienyl rhodium(III) complexes.
in Dalton transactions (Cambridge, England : 2003)
Silva Sousa EH
(2016)
Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1a Inhibition for Cancer Therapy.
in ACS chemical biology
Shi H
(2019)
Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands
in Inorganica Chimica Acta
Shi H
(2022)
Biomedical Applications of Inorganic Photochemistry
Shi H
(2020)
Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes.
in Inorganic chemistry frontiers
Shi H
(2019)
Diazido platinum( iv ) complexes for photoactivated anticancer chemotherapy
in Inorganic Chemistry Frontiers
Shi H
(2020)
Biotinylated photoactive Pt( iv ) anticancer complexes
in Chemical Communications
Shi H
(2021)
DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Shi H
(2019)
Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide.
in Dalton transactions (Cambridge, England : 2003)
Shi H
(2018)
Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.
in Inorganic chemistry
Shaili Evyenia
(2015)
A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin
in CHEMISTRY-A EUROPEAN JOURNAL
Shaili E
(2015)
A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Sargaeva NP
(2011)
Unusual fragmentation of ß-linked peptides by ExD tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Sargaeva NP
(2011)
Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides.
in Electrophoresis
Sargaeva NP
(2011)
Differentiating N-terminal aspartic and isoaspartic acid residues in peptides.
in Analytical chemistry