Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Liu HK
(2016)
"Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes.
in Dalton transactions (Cambridge, England : 2003)
Barry N
(2014)
100 years of metal coordination chemistry: from Alfred Werner to anticancer metallodrugs
in Pure and Applied Chemistry
Lin TY
(2011)
A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry.
in The Review of scientific instruments
Minas G
(2012)
A hybrid procedure for detecting global treatment effects in multivariate clinical trials: theory and applications to fMRI studies.
in Statistics in medicine
Lin TY
(2012)
A low noise single-transistor transimpedance preamplifier for Fourier-transform mass spectrometry using a T feedback network.
in The Review of scientific instruments
Barry NP
(2014)
A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes.
in Dalton transactions (Cambridge, England : 2003)
Dyson M
(2013)
A new approach to high resolution, high contrast electron microscopy of macromolecular block copolymer assemblies
in Soft Matter
Li J
(2017)
A novel strategy to construct Janus metallamacrocycles with both a Ru-arene face and an imidazolium face.
in Dalton transactions (Cambridge, England : 2003)
Shaili Evyenia
(2015)
A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin
in CHEMISTRY-A EUROPEAN JOURNAL
Shaili E
(2015)
A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Qi Y
(2013)
Absorption-mode Fourier transform mass spectrometry: the effects of apodization and phasing on modified protein spectra.
in Journal of the American Society for Mass Spectrometry
Qi Y
(2012)
Absorption-mode spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell.
in Rapid communications in mass spectrometry : RCM
Qi Y
(2012)
Absorption-mode: the next generation of Fourier transform mass spectra.
in Analytical chemistry
Zhang P
(2017)
Advances in the design of organometallic anticancer complexes
in Journal of Organometallic Chemistry
Gandioso A
(2015)
An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies.
in Chemical communications (Cambridge, England)
Soldevila-Barreda JJ
(2015)
Approaches to the design of catalytic metallodrugs.
in Current opinion in chemical biology
Kilgour DP
(2012)
Appropriate degree of trust: deriving confidence metrics for automatic peak assignment in high-resolution mass spectrometry.
in Analytical chemistry
Romero-Canelón I
(2015)
Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)
in Journal of Organometallic Chemistry
Kashtiban RJ
(2014)
Atomically resolved imaging of highly ordered alternating fluorinated graphene.
in Nature communications
Kilgour DP
(2013)
Autophaser: an algorithm for automated generation of absorption mode spectra for FT-ICR MS.
in Analytical chemistry
Shi H
(2020)
Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes.
in Inorganic chemistry frontiers
Carter R
(2014)
Band gap expansion, shear inversion phase change behaviour and low-voltage induced crystal oscillation in low-dimensional tin selenide crystals.
in Dalton transactions (Cambridge, England : 2003)
Chen F
(2018)
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.
in Journal of medicinal chemistry
Wootton CA
(2015)
Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry.
in Dalton transactions (Cambridge, England : 2003)
Chellan P
(2021)
Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin.
in Journal of inorganic biochemistry
Shi H
(2022)
Biomedical Applications of Inorganic Photochemistry
Shi H
(2020)
Biotinylated photoactive Pt( iv ) anticancer complexes
in Chemical Communications
Spencer J
(2016)
Coherence lifetime broadened optical transitions in a 2 atom diameter HgTe nanowire: a temperature dependent resonance Raman study
in RSC Advances
Smith NA
(2017)
Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.
in Chemical science
Pizarro A
(2013)
Comprehensive Inorganic Chemistry II
Millett A
(2015)
Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands
in Organometallics
Pitto-Barry A
(2017)
Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy.
in Chemical communications (Cambridge, England)
Armstrong J
(2023)
Correction to "Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex".
in The journal of physical chemistry letters
Donnelly JM
(2021)
Cu(III)-bis-thiolato complex forms an unusual mono-thiolato Cu(III)-peroxido adduct.
in Chemical communications (Cambridge, England)
Wei J
(2014)
D-a-tocopheryl polyethylene glycol 1000 succinate: a view from FTICR MS and tandem MS.
in Analytical chemistry
Perez Hurtado P
(2012)
Deamidation of Collagen
in Analytical Chemistry
Lam YPY
(2020)
Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Lopez-Clavijo AF
(2012)
Determination of types and binding sites of advanced glycation end products for substance P.
in Analytical chemistry
Shi H
(2019)
Diazido platinum( iv ) complexes for photoactivated anticancer chemotherapy
in Inorganic Chemistry Frontiers
Sargaeva NP
(2011)
Differentiating N-terminal aspartic and isoaspartic acid residues in peptides.
in Analytical chemistry
Chen P
(2019)
Discovery of novel, potent, isosteviol-based antithrombotic agents.
in European journal of medicinal chemistry
Shi H
(2021)
DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Lam YPY
(2018)
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
in Chemical communications (Cambridge, England)
Kumar SA
(2021)
Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice.
in Metallomics : integrated biometal science
Shi H
(2019)
Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands
in Inorganica Chimica Acta
Banerjee S
(2019)
Dual-action platinum(II) Schiff base complexes: Photocytotoxicity and cellular imaging
in Polyhedron
Pitto-Barry A
(2016)
Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces.
in Chemical communications (Cambridge, England)
Coverdale JP
(2015)
Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chen F
(2022)
Effect of cysteine thiols on the catalytic and anticancer activity of Ru(II) sulfonyl-ethylenediamine complexes.
in Dalton transactions (Cambridge, England : 2003)
Li H
(2012)
Electron capture dissociation of disulfide, sulfur-selenium, and diselenide bound peptides.
in Journal of the American Society for Mass Spectrometry