Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Sriskandakumar T
(2015)
Electrophilic Activation of Oxidized Sulfur Ligands and Implications for the Biological Activity of Ruthenium(II) Arene Anticancer Complexes.
in Inorganic chemistry
Chellan P
(2020)
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Banerjee S
(2024)
Experimental and theoretical evidence for unprecedented strong interactions of gold atoms with boron on boron/sulfur-doped carbon surfaces
in Nanoscale Advances
Barry NP
(2013)
Exploration of the medical periodic table: towards new targets.
in Chemical communications (Cambridge, England)
Wei J
(2015)
Extensive fragmentation of pheophytin-a by infrared multiphoton dissociation tandem mass spectrometry.
in Rapid communications in mass spectrometry : RCM
Barry NP
(2014)
Fabrication of crystals from single metal atoms.
in Nature communications
Banerjee S
(2019)
Generation of maghemite nanocrystals from iron-sulfur centres.
in Dalton transactions (Cambridge, England : 2003)
Zhang X
(2019)
Glutathione activation of an organometallic half-sandwich anticancer drug candidate by ligand attack.
in Chemical communications (Cambridge, England)
Gatti A
(2018)
Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity.
in Organometallics
Bichoutskaia E
(2012)
High-precision imaging of an encapsulated Lindqvist ion and correlation of its structure and symmetry with quantum chemical calculations
in Nanoscale
Mukherjee A
(2014)
Human Serum Transferrin Fibrils: Nanomineralisation in Bacteria and Destruction of Red Blood Cells
in ChemBioChem
Å tarha P
(2016)
Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes.
in Inorganic chemistry
Coverdale J
(2018)
In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
in Journal of Medicinal Chemistry
Needham RJ
(2017)
In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.
in Angewandte Chemie (International ed. in English)
Novohradsky V
(2020)
Induction of immunogenic cell death in cancer cells by a photoactivated platinum(IV) prodrug.
in Inorganic chemistry frontiers
Wills R
(2014)
Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry
in Journal of the American Society for Mass Spectrometry
Marsden A
(2013)
Is graphene on copper doped?
in physica status solidi (RRL) - Rapid Research Letters
Ballesta A
(2019)
Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells.
in Metallomics : integrated biometal science
Sink A
(2022)
Kinetics and mechanism of sequential ring methyl C-H activation in cyclopentadienyl rhodium(III) complexes.
in Dalton transactions (Cambridge, England : 2003)
Nightingale A
(2013)
Large-scale synthesis of nanocrystals in a multichannel droplet reactor
in Journal of Materials Chemistry A
Zhang WY
(2020)
Ligand-centred redox activation of inert organoiridium anticancer catalysts.
in Chemical science
Bisceglie F
(2022)
Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (?6-arene)ruthenium(II) Complexes.
in International journal of molecular sciences
Qi Y
(2013)
Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation.
in Rapid communications in mass spectrometry : RCM
Li H
(2014)
Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins.
in Journal of the American Society for Mass Spectrometry
Li H
(2011)
Mass spectrometry evidence for cisplatin as a protein cross-linking reagent.
in Analytical chemistry
Sanchez-Cano C
(2018)
Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex.
in Journal of inorganic biochemistry
Venkatesh V
(2017)
Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes.
in Chemical science
Sanchez-Cano C
(2019)
Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells.
in Chemical communications (Cambridge, England)
Wang Y
(2016)
Nanoparticles of chitosan conjugated to organo-ruthenium complexes
in Inorganic Chemistry Frontiers
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Imberti C
(2020)
New Designs for Phototherapeutic Transition Metal Complexes.
in Angewandte Chemie (International ed. in English)
Needham RJ
(2021)
NMR studies of group 8 metallodrugs: 187Os-enriched organo-osmium half-sandwich anticancer complex.
in Dalton transactions (Cambridge, England : 2003)
Oliveira C
(2020)
Novel tetranuclear Pd II and Pt II anticancer complexes derived from pyrene thiosemicarbazones
in Dalton Transactions
Wilson N
(2010)
On the structure and topography of free-standing chemically modified graphene
in New Journal of Physics
Chellan P
(2018)
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Fu Y
(2016)
Os 2 -Os 4 Switch Controls DNA Knotting and Anticancer Activity
in Angewandte Chemie
Fu Y
(2016)
Os2 -Os4 Switch Controls DNA Knotting and Anticancer Activity.
in Angewandte Chemie (International ed. in English)
Oliveira CG
(2019)
Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
in Dalton transactions (Cambridge, England : 2003)
Pandey P
(2013)
Pd-doped reduced graphene oxide sensing films for H2 detection
in Sensors and Actuators B: Chemical
Qi Y
(2011)
Phase correction of Fourier transform ion cyclotron resonance mass spectra using MatLab.
in Journal of the American Society for Mass Spectrometry
Brabec V
(2016)
Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.
in Journal of inorganic biochemistry
Shi H
(2018)
Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.
in Inorganic chemistry
Vallotto C
(2018)
Photoactivatable platinum anticancer complex can generate tryptophan radicals.
in Chemical communications (Cambridge, England)
Xue X
(2021)
Photoactivated Osmium Arene Anticancer Complexes.
in Inorganic chemistry
Farley SJ
(2022)
Photoactive Platinum(II) Azopyridine Complexes.
in Photochemistry and photobiology
Shi H
(2019)
Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide.
in Dalton transactions (Cambridge, England : 2003)
Chen JS
(2010)
Photochemistry in photonic crystal fiber nanoreactors.
in Chemistry (Weinheim an der Bergstrasse, Germany)