Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Pandey PA
(2011)
Physical vapor deposition of metal nanoparticles on chemically modified graphene: observations on metal-graphene interactions.
in Small (Weinheim an der Bergstrasse, Germany)
Gondim A
(2019)
Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity
in MedChemComm
Barry NP
(2014)
Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.
in Faraday discussions
Li H
(2012)
Protein flexibility is key to cisplatin crosslinking in calmodulin.
in Protein science : a publication of the Protein Society
Carter R
(2016)
Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes
in Scientific Reports
Wang FX
(2022)
Reactions of cisplatin and oxaliplatin with penicillin G: implications for drug inactivation and biological activity.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Zhang P
(2017)
Redox-Active Metal Complexes for Anticancer Therapy
in European Journal of Inorganic Chemistry
Pandey P
(2012)
Resolving the Nanoscale Morphology and Crystallographic Structure of Molecular Thin Films: F 16 CuPc on Graphene Oxide
in Chemistry of Materials
Faulques E
(2016)
Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems
in Journal of Visualized Experiments
Smith DC
(2016)
Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems.
in Journal of visualized experiments : JoVE
Wu Q
(2018)
Rigid dinuclear ruthenium-arene complexes showing strong DNA interactions.
in Journal of inorganic biochemistry
Páez C
(2012)
Robust signatures in the current-voltage characteristics of DNA molecules oriented between two graphene nanoribbon electrodes
in New Journal of Physics
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Sargaeva NP
(2011)
Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides.
in Electrophoresis
Zou T
(2015)
Speciation of precious metal anti-cancer complexes by NMR spectroscopy.
in Drug discovery today. Technologies
Wootton CA
(2019)
Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation.
in The Analyst
Wills RH
(2014)
Structural characterization of actinomycin D using multiple ion isolation and electron induced dissociation.
in Journal of the American Society for Mass Spectrometry
Wei J
(2013)
Structural characterization of chlorophyll-a by high resolution tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Wills RH
(2012)
Structural characterization of polyketides using high mass accuracy tandem mass spectrometry.
in Analytical chemistry
Sun L
(2014)
Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation.
in Nature communications
Needham RJ
(2020)
Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents.
in Journal of inorganic biochemistry
Lopez-Clavijo AF
(2014)
Study of an unusual advanced glycation end-product (AGE) derived from glyoxal using mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Sanchez-Cano C
(2017)
Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Xie MJ
(2017)
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV.
in Journal of inorganic biochemistry
Pitto-Barry A
(2015)
Synthesis and controlled growth of osmium nanoparticles by electron irradiation.
in Dalton transactions (Cambridge, England : 2003)
Gothe Y
(2018)
Synthesis and Mode of Action Studies on Iridium(I)-NHC Anticancer Drug Candidates
in European Journal of Inorganic Chemistry
Smith N
(2017)
Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes
in Inorganica Chimica Acta
Romero-Canelón I
(2015)
Systems approach to metal-based pharmacology.
in Proceedings of the National Academy of Sciences of the United States of America
Lopez-Clavijo A
(2013)
Tandem mass spectrometry for the study of glyoxal-derived advanced glycation end-products (AGEs) in peptides
in Rapid Communications in Mass Spectrometry
Huang H
(2019)
Targeted photoredox catalysis in cancer cells.
in Nature chemistry
Wei J
(2015)
The Competitive influence of Li+, Na+, K+, Ag+, and H+ on the fragmentation of a PEGylated polymeric excipient.
in Journal of the American Society for Mass Spectrometry
Fu Y
(2016)
The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts.
in Dalton transactions (Cambridge, England : 2003)
Lopes L
(2020)
THE FUNDAMENTAL IMPORTANCE OF BASIC SCIENCE: EXAMPLES OF HIGH-IMPACT DISCOVERIES FROM AN INTERNATIONAL CHEMISTRY NETWORK
in Química Nova
Gondim ACS
(2017)
The potent anti-cancer activity of Dioclea lasiocarpa lectin.
in Journal of inorganic biochemistry
Silva Sousa EH
(2016)
Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1a Inhibition for Cancer Therapy.
in ACS chemical biology
Li X
(2012)
Top-down study of ß2-microglobulin deamidation.
in Analytical chemistry
Chen F
(2018)
Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts.
in Organometallics
Soldevila-Barreda JJ
(2015)
Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design.
in Nature communications
Lopez-Clavijo AF
(2014)
Unexpected crosslinking and diglycation as advanced glycation end-products from glyoxal.
in Journal of the American Society for Mass Spectrometry
Sargaeva NP
(2011)
Unusual fragmentation of ß-linked peptides by ExD tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Kilgour DP
(2012)
Use of an artificial immune system derived method for the charge state assignment of small-molecule mass spectra.
in Analytical chemistry
Perez Hurtado P
(2012)
Use of high resolution mass spectrometry for analysis of polymeric excipients in drug delivery formulations.
in Analytical chemistry
Qi Y
(2011)
Variation of the Fourier transform mass spectra phase function with experimental parameters.
in Analytical chemistry
Armstrong J
(2021)
Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex.
in The journal of physical chemistry letters
Wilson N
(2013)
Weak mismatch epitaxy and structural Feedback in graphene growth on copper foil
in Nano Research
Bolitho EM
(2020)
X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry