Magnetic Resonance: From the Laboratory to Industrial Practice
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
Magnetic Resonance Imaging is widely used in hospitals to image blood flow and the internal structure of the human body. Our work focuses on extending these magnetic resonance (MR) techniques to study chemical products and processes. Over the past 5 years we have established an internationally respected skill base in developing MR techniques to study transport in porous materials (e.g. oil flow in rocks), transport and reaction in 3-D systems (e.g. chemical conversion occurring inside catalytic reactors) and processing structure-function relationships (e.g. effect of extrusion processing on the structure and texture of food products). We believe that we now have the research base in place to make a step-change in exploiting MR in industrial practice. To achieve this, we wish to extend our research activities by (i) improving signal-to-noise ratios and speeding up data acquisition times such that we will be able to image hydrodynamics and chemical conversion over much shorter timescales than we can now; our target is to reduce data acquisition times by an order of magnitude; and (ii) developing robust methods for mapping pH, oxygen content, temperature and pressure, and constructing realistic process environments (e.g. elevated pressure and temperature) within the MR magnet. As well as being able to make new measurements under realistic process conditions, these data will also enable us to understand the microscopic physical and chemical processes occurring in these complex systems such that we can work with those developing numerical codes of chemical processes to improve and validate the scientific assumptions and models incorporated in their process design tools. Finally, in collaboration with experts in low-field MR hardware (which is cheap, compact and relatively maintenance free compared with high-field technology) we will bring together our advances in reduced data acquisitions times and signal enhancement with their magnet technology to demonstrate MR measurements in the industrial R&D laboratory and eventually on plant.
Organisations
Publications
Shen Y
(2009)
Terahertz pulsed spectroscopic imaging using optimized binary masks
in Applied Physics Letters
Sankey M
(2009)
SPRITE MRI of bubbly flow in a horizontal pipe.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Griffith J
(2009)
In situ monitoring of the microstructure of detergent drops during drying using a rapid nuclear magnetic resonance diffusion measurement
in Journal of Materials Science
Creber SA
(2009)
Quantification of the velocity acceleration factor for colloidal transport in porous media using NMR.
in Journal of colloid and interface science
Müller C
(2009)
Geometrical and hydrodynamical study of gas jets in packed and fluidized beds using magnetic resonance
in The Canadian Journal of Chemical Engineering
Parrott E
(2009)
The Use of Terahertz Spectroscopy as a Sensitive Probe in Discriminating the Electronic Properties of Structurally Similar Multi-Walled Carbon Nanotubes
in Advanced Materials
Parrott E
(2009)
Extracting accurate optical parameters from glasses usingterahertz time-domain spectroscopy
in Journal of Non-Crystalline Solids
VAN DE MEENT J
(2009)
Measurement of cytoplasmic streaming in single plant cells by magnetic resonance velocimetry
in Journal of Fluid Mechanics
Youngs T
(2009)
Liquid Structure and Dynamics of Aqueous Isopropanol over ?-Alumina
in The Journal of Physical Chemistry C
Parasoglou P
(2009)
Quantitative single point imaging with compressed sensing.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Song K
(2009)
Magnetic resonance studies of hydration kinetics and microstructural evolution in plaster pastes
in Journal of Materials Science
Holland D
(2010)
Reducing data acquisition times in phase-encoded velocity imaging using compressed sensing
in Journal of Magnetic Resonance
Gladden L
(2010)
MRI: Operando measurements of temperature, hydrodynamics and local reaction rate in a heterogeneous catalytic reactor
in Catalysis Today
Bowron DT
(2010)
Structure and dynamics of 1-ethyl-3-methylimidazolium acetate via molecular dynamics and neutron diffraction.
in The journal of physical chemistry. B
Li R
(2010)
A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid.
in Physical chemistry chemical physics : PCCP
Xiaoxia Yin
(2010)
Local Computed Tomography Using a THz Quantum Cascade Laser
in IEEE Sensors Journal
Creber S
(2010)
Magnetic resonance imaging and 3D simulation studies of biofilm accumulation and cleaning on reverse osmosis membranes
in Food and Bioproducts Processing
Beauregard DA
(2010)
Using non-invasive magnetic resonance imaging (MRI) to assess the reduction of Cr(VI) using a biofilm-palladium catalyst.
in Biotechnology and bioengineering
Müller CR
(2010)
Magnetic resonance measurements of high-velocity particle motion in a three-dimensional gas-solid spouted bed.
in Physical review. E, Statistical, nonlinear, and soft matter physics
Pintelon TR
(2010)
Validation of 3D simulations of reverse osmosis membrane biofouling.
in Biotechnology and bioengineering
Parrott E
(2010)
Atomic charge distribution in sodosilicate glasses from terahertz time-domain spectroscopy
in Physical Review B
Weber D
(2010)
Surface diffusion in porous catalysts.
in Physical chemistry chemical physics : PCCP
Tayler AB
(2010)
'Snap-shot' velocity vector mapping using echo-planar imaging.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Mantle M
(2010)
Pulsed-Field Gradient NMR Spectroscopic Studies of Alcohols in Supported Gold Catalysts
in The Journal of Physical Chemistry C
Holland D
(2010)
Magnetic Resonance Studies of Fluidization Regimes
in Industrial & Engineering Chemistry Research
Stevenson R
(2010)
Analysis of partial suspension in stirred mixing cells using both MRI and ERT
in Chemical Engineering Science
Creber S
(2010)
Chemical cleaning of biofouling in reverse osmosis membranes evaluated using magnetic resonance imaging
in Journal of Membrane Science
Ding T
(2010)
Terahertz and far infrared spectroscopy of alanine-rich peptides having variable ellipticity.
in Optics express
Mitchell J
(2010)
Obtaining true transverse relaxation time distributions in high-field NMR measurements of saturated porous media: Removing the influence of internal gradients.
in The Journal of chemical physics
Laity P
(2010)
Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation
in European Journal of Pharmaceutics and Biopharmaceutics
McGregor J
(2010)
Active coke: Carbonaceous materials as catalysts for alkane dehydrogenation
in Journal of Catalysis
Chen YY
(2010)
Quantitative ultra-fast MRI of HPMC swelling and dissolution.
in Journal of pharmaceutical sciences
Davies CJ
(2010)
Rapid measurement of transient velocity evolution using GERVAIS.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Pore M
(2010)
Magnetic resonance studies of a gas-solids fluidised bed: Jet-jet and jet-wall interactions
in Particuology
Mitchell J
(2010)
Nuclear magnetic resonance relaxation and diffusion in the presence of internal gradients: the effect of magnetic field strength.
in Physical review. E, Statistical, nonlinear, and soft matter physics
Somasundram I
(2010)
2-D simulation of wick debinding for ceramic parts in close proximity
in Chemical Engineering Science
McGregor J
(2010)
The influence of carbon laydown on selectivity in the hydrogenation of pentenenitriles over supported-nickel catalysts
in Applied Catalysis A: General
Stevenson P
(2010)
Measurement of bubble size distribution in a gas-liquid foam using pulsed-field gradient nuclear magnetic resonance.
in Journal of colloid and interface science
D'Agostino C
(2011)
Molecular motion and ion diffusion in choline chloride based deep eutectic solvents studied by 1H pulsed field gradient NMR spectroscopy.
in Physical chemistry chemical physics : PCCP
Holland DJ
(2011)
A Bayesian approach to characterising multi-phase flows using magnetic resonance: application to bubble flows.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Mantle M
(2011)
Quantitative magnetic resonance micro-imaging methods for pharmaceutical research
in International Journal of Pharmaceutics
Weber D
(2011)
Spatially and chemically resolved measurement of intra- and inter-particle molecular diffusion in a fixed-bed reactor
in Applied Catalysis A: General
Hussain R
(2011)
Using NMR displacement measurements to probe CO2 entrapment in porous media
in AIChE Journal
Fridjonsson E
(2011)
Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor-Couette shear cell
in Soft Matter
D'Agostino C
(2011)
Prediction of binary diffusion coefficients in non-ideal mixtures from NMR data: Hexane-nitrobenzene near its consolute point
in Chemical Engineering Science
Description | This was a Platform Grant and therefore covered a wide range of method development in magnetic resonance in application to chemical engineering and the process industries. A large number of the projects initiated within this grant are now supported by industrial funding. Research methods which have been continued in such projects include undersampling methods in NMR such as compressed sensing and Bayesian methods; in situ/operando studies of catalysis; and new measurements capabilities at low field. Industrial collaborators include: Johnson Matthey, Shell, Schlumberger, BP and AstraZeneca. |
First Year Of Impact | 2013 |
Sector | Chemicals,Energy,Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Title | Research data supporting "Retaining both discrete and smooth features in 1D and 2D NMR relaxation and diffusion experiments" |
Description | data used in associated publication |
Type Of Material | Database/Collection of data |
Provided To Others? | Yes |
Title | Research data supporting "Study of bubble dynamics in gas-solid fluidized beds using ultrashort echo time (UTE) magnetic resonance imaging (MRI)" |
Description | data associated with paper |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |