Magnetic Resonance: From the Laboratory to Industrial Practice
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
Magnetic Resonance Imaging is widely used in hospitals to image blood flow and the internal structure of the human body. Our work focuses on extending these magnetic resonance (MR) techniques to study chemical products and processes. Over the past 5 years we have established an internationally respected skill base in developing MR techniques to study transport in porous materials (e.g. oil flow in rocks), transport and reaction in 3-D systems (e.g. chemical conversion occurring inside catalytic reactors) and processing structure-function relationships (e.g. effect of extrusion processing on the structure and texture of food products). We believe that we now have the research base in place to make a step-change in exploiting MR in industrial practice. To achieve this, we wish to extend our research activities by (i) improving signal-to-noise ratios and speeding up data acquisition times such that we will be able to image hydrodynamics and chemical conversion over much shorter timescales than we can now; our target is to reduce data acquisition times by an order of magnitude; and (ii) developing robust methods for mapping pH, oxygen content, temperature and pressure, and constructing realistic process environments (e.g. elevated pressure and temperature) within the MR magnet. As well as being able to make new measurements under realistic process conditions, these data will also enable us to understand the microscopic physical and chemical processes occurring in these complex systems such that we can work with those developing numerical codes of chemical processes to improve and validate the scientific assumptions and models incorporated in their process design tools. Finally, in collaboration with experts in low-field MR hardware (which is cheap, compact and relatively maintenance free compared with high-field technology) we will bring together our advances in reduced data acquisitions times and signal enhancement with their magnet technology to demonstrate MR measurements in the industrial R&D laboratory and eventually on plant.
Organisations
Publications
Abbott A
(2011)
Glycerol eutectics as sustainable solvent systems
in Green Chem.
Abeynaike A
(2012)
The experimental measurement and modelling of sedimentation and creaming for glycerol/biodiesel droplet dispersions
in Chemical Engineering Science
Akpa B
(2012)
Solvent effects in the hydrogenation of 2-butanone
in Journal of Catalysis
Beauregard DA
(2010)
Using non-invasive magnetic resonance imaging (MRI) to assess the reduction of Cr(VI) using a biofilm-palladium catalyst.
in Biotechnology and bioengineering
Benning M
(2014)
Phase reconstruction from velocity-encoded MRI measurements--a survey of sparsity-promoting variational approaches.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Blythe TW
(2015)
Characterising the rheology of non-Newtonian fluids using PFG-NMR and cumulant analysis.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Blythe TW
(2017)
PFG NMR and Bayesian analysis to characterise non-Newtonian fluids.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Bostock MJ
(2012)
Compressed sensing reconstruction of undersampled 3D NOESY spectra: application to large membrane proteins.
in Journal of biomolecular NMR
Bowron DT
(2010)
Structure and dynamics of 1-ethyl-3-methylimidazolium acetate via molecular dynamics and neutron diffraction.
in The journal of physical chemistry. B
Chandrasekera T
(2012)
A comparison of magnetic resonance imaging and electrical capacitance tomography: An air jet through a bed of particles
in Powder Technology
Chen C
(2014)
Direct visualization of in vitro drug mobilization from Lescol XL tablets using two-dimensional (19)F and (1)H magnetic resonance imaging.
in Molecular pharmaceutics
Chen YY
(2010)
Quantitative ultra-fast MRI of HPMC swelling and dissolution.
in Journal of pharmaceutical sciences
Collins J
(2017)
Characterising gas behaviour during gas-liquid co-current up-flow in packed beds using magnetic resonance imaging
in Chemical Engineering Science
Creber S
(2010)
Chemical cleaning of biofouling in reverse osmosis membranes evaluated using magnetic resonance imaging
in Journal of Membrane Science
Creber S
(2010)
Magnetic resonance imaging and 3D simulation studies of biofilm accumulation and cleaning on reverse osmosis membranes
in Food and Bioproducts Processing
Creber SA
(2009)
Quantification of the velocity acceleration factor for colloidal transport in porous media using NMR.
in Journal of colloid and interface science
D'Agostino C
(2012)
Prediction of mutual diffusion coefficients in non-ideal mixtures from pulsed field gradient NMR data: Triethylamine-water near its consolute point
in Chemical Engineering Science
D'Agostino C
(2012)
Understanding the solvent effect on the catalytic oxidation of 1,4-butanediol in methanol over Au/TiO2 catalyst: NMR diffusion and relaxation studies.
in Chemistry (Weinheim an der Bergstrasse, Germany)
D'Agostino C
(2014)
Deactivation studies of a carbon supported AuPt nanoparticulate catalyst in the liquid-phase aerobic oxidation of 1,2-propanediol
in Catal. Sci. Technol.
D'Agostino C
(2011)
Prediction of binary diffusion coefficients in non-ideal mixtures from NMR data: Hexane-nitrobenzene near its consolute point
in Chemical Engineering Science
D'Agostino C
(2013)
Solvent effect and reactivity trend in the aerobic oxidation of 1,3-propanediols over gold supported on titania: NMR diffusion and relaxation studies.
in Chemistry (Weinheim an der Bergstrasse, Germany)
D'Agostino C
(2012)
Hydrogen Bonding Network Disruption in Mesoporous Catalyst Supports Probed by PFG-NMR Diffusometry and NMR Relaxometry
in The Journal of Physical Chemistry C
D'Agostino C
(2011)
Molecular motion and ion diffusion in choline chloride based deep eutectic solvents studied by 1H pulsed field gradient NMR spectroscopy.
in Physical chemistry chemical physics : PCCP
Davies CJ
(2010)
Rapid measurement of transient velocity evolution using GERVAIS.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Ding T
(2010)
Terahertz and far infrared spectroscopy of alanine-rich peptides having variable ellipticity.
in Optics express
Fabich H
(2016)
Development of ultrafast UTE imaging for granular systems
Fabich H
(2017)
Study of bubble dynamics in gas-solid fluidized beds using ultrashort echo time (UTE) magnetic resonance imaging (MRI)
in Chemical Engineering Science
Fabich H
(2016)
Development of ultrafast UTE imaging for granular systems
in Journal of Magnetic Resonance
Fabich HT
(2014)
Ultrashort echo time (UTE) imaging using gradient pre-equalization and compressed sensing.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Fagan MA
(2012)
MR imaging of ore for heap bioleaching studies using pure phase encode acquisition methods.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Fridjonsson E
(2011)
Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor-Couette shear cell
in Soft Matter
Fridjonsson EO
(2012)
Determination of mean droplet sizes of water-in-oil emulsions using an Earth's field NMR instrument.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Gladden L
(2011)
Measuring adsorption, diffusion and flow in chemical engineering: applications of magnetic resonance to porous media
in New Journal of Physics
Gladden L
(2010)
MRI: Operando measurements of temperature, hydrodynamics and local reaction rate in a heterogeneous catalytic reactor
in Catalysis Today
Gladden L
(2013)
Magnetic resonance in reaction engineering: beyond spectroscopy
in Current Opinion in Chemical Engineering
Graf Von Der Schulenburg D
(2011)
Catalyst effectiveness factor distributions in isothermal packed bed reactors
in Chemical Engineering Science
Griffith J
(2009)
In situ monitoring of the microstructure of detergent drops during drying using a rapid nuclear magnetic resonance diffusion measurement
in Journal of Materials Science
Holland D
(2012)
Bubble size measurement using Bayesian magnetic resonance
in Chemical Engineering Science
Holland D
(2010)
Reducing data acquisition times in phase-encoded velocity imaging using compressed sensing
in Journal of Magnetic Resonance
Holland D
(2010)
Magnetic Resonance Studies of Fluidization Regimes
in Industrial & Engineering Chemistry Research
Holland D
(2013)
Grain Sizing in Porous Media using Bayesian Magnetic Resonance
in Physical Review Letters
Holland DJ
(2013)
Compressed sensing reconstruction improves sensitivity of variable density spiral fMRI.
in Magnetic resonance in medicine
Holland DJ
(2011)
Fast multidimensional NMR spectroscopy using compressed sensing.
in Angewandte Chemie (International ed. in English)
Holland DJ
(2011)
A Bayesian approach to characterising multi-phase flows using magnetic resonance: application to bubble flows.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Hughes E
(2013)
Microfluidic preparation and self diffusion PFG-NMR analysis of monodisperse water-in-oil-in-water double emulsions.
in Journal of colloid and interface science
Hughes T
(2012)
CO2 sequestration for enhanced gas recovery: New measurements of supercritical CO2-CH4 dispersion in porous media and a review of recent research
in International Journal of Greenhouse Gas Control
Hussain R
(2011)
Using NMR displacement measurements to probe CO2 entrapment in porous media
in AIChE Journal
Description | This was a Platform Grant and therefore covered a wide range of method development in magnetic resonance in application to chemical engineering and the process industries. A large number of the projects initiated within this grant are now supported by industrial funding. Research methods which have been continued in such projects include undersampling methods in NMR such as compressed sensing and Bayesian methods; in situ/operando studies of catalysis; and new measurements capabilities at low field. Industrial collaborators include: Johnson Matthey, Shell, Schlumberger, BP and AstraZeneca. |
First Year Of Impact | 2013 |
Sector | Chemicals,Energy,Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Title | Research data supporting "Retaining both discrete and smooth features in 1D and 2D NMR relaxation and diffusion experiments" |
Description | data used in associated publication |
Type Of Material | Database/Collection of data |
Provided To Others? | Yes |
Title | Research data supporting "Study of bubble dynamics in gas-solid fluidized beds using ultrashort echo time (UTE) magnetic resonance imaging (MRI)" |
Description | data associated with paper |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |