Magnetic Resonance: From the Laboratory to Industrial Practice
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
Magnetic Resonance Imaging is widely used in hospitals to image blood flow and the internal structure of the human body. Our work focuses on extending these magnetic resonance (MR) techniques to study chemical products and processes. Over the past 5 years we have established an internationally respected skill base in developing MR techniques to study transport in porous materials (e.g. oil flow in rocks), transport and reaction in 3-D systems (e.g. chemical conversion occurring inside catalytic reactors) and processing structure-function relationships (e.g. effect of extrusion processing on the structure and texture of food products). We believe that we now have the research base in place to make a step-change in exploiting MR in industrial practice. To achieve this, we wish to extend our research activities by (i) improving signal-to-noise ratios and speeding up data acquisition times such that we will be able to image hydrodynamics and chemical conversion over much shorter timescales than we can now; our target is to reduce data acquisition times by an order of magnitude; and (ii) developing robust methods for mapping pH, oxygen content, temperature and pressure, and constructing realistic process environments (e.g. elevated pressure and temperature) within the MR magnet. As well as being able to make new measurements under realistic process conditions, these data will also enable us to understand the microscopic physical and chemical processes occurring in these complex systems such that we can work with those developing numerical codes of chemical processes to improve and validate the scientific assumptions and models incorporated in their process design tools. Finally, in collaboration with experts in low-field MR hardware (which is cheap, compact and relatively maintenance free compared with high-field technology) we will bring together our advances in reduced data acquisitions times and signal enhancement with their magnet technology to demonstrate MR measurements in the industrial R&D laboratory and eventually on plant.
Organisations
Publications
Laity P
(2010)
Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation
in European Journal of Pharmaceutics and Biopharmaceutics
Li R
(2010)
A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid.
in Physical chemistry chemical physics : PCCP
Lingwood IA
(2012)
Emulsion droplet sizing using low-field NMR with chemical shift resolution and the block gradient pulse method.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Lingwood MD
(2012)
Overhauser dynamic nuclear polarization amplification of NMR flow imaging.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Mantle M
(2013)
NMR and MRI studies of drug delivery systems
in Current Opinion in Colloid & Interface Science
Mantle M
(2011)
Quantitative magnetic resonance micro-imaging methods for pharmaceutical research
in International Journal of Pharmaceutics
Mantle M
(2010)
Pulsed-Field Gradient NMR Spectroscopic Studies of Alcohols in Supported Gold Catalysts
in The Journal of Physical Chemistry C
McGregor J
(2010)
Active coke: Carbonaceous materials as catalysts for alkane dehydrogenation
in Journal of Catalysis
McGregor J
(2010)
The influence of carbon laydown on selectivity in the hydrogenation of pentenenitriles over supported-nickel catalysts
in Applied Catalysis A: General
Mitchell J
(2013)
Magnetic resonance imaging in laboratory petrophysical core analysis
in Physics Reports
Mitchell J
(2014)
Low-field permanent magnets for industrial process and quality control.
in Progress in nuclear magnetic resonance spectroscopy
Mitchell J
(2013)
Measurement of the true transverse nuclear magnetic resonance relaxation in the presence of field gradients.
in The Journal of chemical physics
Mitchell J
(2010)
Obtaining true transverse relaxation time distributions in high-field NMR measurements of saturated porous media: Removing the influence of internal gradients.
in The Journal of chemical physics
Mitchell J
(2013)
A General approach to T 2 measurements in the presence of internal gradients
in Microporous and Mesoporous Materials
Mitchell J
(2013)
Exploring Surface Interactions in Catalysts Using Low-Field Nuclear Magnetic Resonance
in The Journal of Physical Chemistry C
Mitchell J
(2012)
Numerical estimation of relaxation and diffusion distributions in two dimensions.
in Progress in nuclear magnetic resonance spectroscopy
Mitchell J
(2010)
Nuclear magnetic resonance relaxation and diffusion in the presence of internal gradients: the effect of magnetic field strength.
in Physical review. E, Statistical, nonlinear, and soft matter physics
Müller C
(2009)
Geometrical and hydrodynamical study of gas jets in packed and fluidized beds using magnetic resonance
in The Canadian Journal of Chemical Engineering
Müller C
(2011)
Multi-scale magnetic resonance measurements and validation of Discrete Element Model simulations
in Particuology
Müller CR
(2010)
Magnetic resonance measurements of high-velocity particle motion in a three-dimensional gas-solid spouted bed.
in Physical review. E, Statistical, nonlinear, and soft matter physics
Nguyen TT
(2011)
Segregation in horizontal rotating cylinders using magnetic resonance imaging.
in Physical review. E, Statistical, nonlinear, and soft matter physics
Parasoglou P
(2009)
Quantitative single point imaging with compressed sensing.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Parrott E
(2010)
Atomic charge distribution in sodosilicate glasses from terahertz time-domain spectroscopy
in Physical Review B
Parrott E
(2009)
The Use of Terahertz Spectroscopy as a Sensitive Probe in Discriminating the Electronic Properties of Structurally Similar Multi-Walled Carbon Nanotubes
in Advanced Materials
Parrott E
(2009)
Extracting accurate optical parameters from glasses usingterahertz time-domain spectroscopy
in Journal of Non-Crystalline Solids
Pintelon TR
(2012)
The effect of biofilm permeability on bio-clogging of porous media.
in Biotechnology and bioengineering
Pintelon TR
(2010)
Validation of 3D simulations of reverse osmosis membrane biofouling.
in Biotechnology and bioengineering
Pore M
(2012)
Magnetic resonance studies of jets in a gas-solid fluidised bed
in Particuology
Pore M
(2010)
Magnetic resonance studies of a gas-solids fluidised bed: Jet-jet and jet-wall interactions
in Particuology
Robbins D
(2012)
CFD modeling of single-phase flow in a packed bed with MRI validation
in AIChE Journal
Roberts S
(2013)
Operando magnetic resonance: monitoring the evolution of conversion and product distribution during the heterogeneous catalytic ethene oligomerisation reaction
in Chemical Communications
Ross JG
(2012)
Extending the use of Earth's Field NMR using Bayesian methodology: application to particle sizing.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Sankey M
(2009)
SPRITE MRI of bubbly flow in a horizontal pipe.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Shen Y
(2009)
Terahertz pulsed spectroscopic imaging using optimized binary masks
in Applied Physics Letters
Shiko G
(2012)
MRI technique for the snapshot imaging of quantitative velocity maps using RARE.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Shiko G
(2011)
MRI studies of the hydrodynamics in a USP 4 dissolution testing cell.
in Journal of pharmaceutical sciences
Somasundram I
(2010)
2-D simulation of wick debinding for ceramic parts in close proximity
in Chemical Engineering Science
Song K
(2011)
Magnetic resonance imaging studies of spontaneous capillary water imbibition in aerated gypsum
in Journal of Physics D: Applied Physics
Song K
(2012)
Monitoring water transport between pores and voids in aerated gypsum using two-dimensional nuclear magnetic resonance exchange measurements
in Journal of Physics D: Applied Physics
Song K
(2009)
Magnetic resonance studies of hydration kinetics and microstructural evolution in plaster pastes
in Journal of Materials Science
Stevenson P
(2010)
Measurement of bubble size distribution in a gas-liquid foam using pulsed-field gradient nuclear magnetic resonance.
in Journal of colloid and interface science
Stevenson R
(2010)
Analysis of partial suspension in stirred mixing cells using both MRI and ERT
in Chemical Engineering Science
Tayler A
(2012)
Applications of ultra-fast MRI to high voidage bubbly flow: Measurement of bubble size distributions, interfacial area and hydrodynamics
in Chemical Engineering Science
Tayler AB
(2014)
Ultrafast magnetic-resonance-imaging velocimetry of liquid-liquid systems: overcoming chemical-shift artifacts using compressed sensing.
in Physical review. E, Statistical, nonlinear, and soft matter physics
Tayler AB
(2010)
'Snap-shot' velocity vector mapping using echo-planar imaging.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Tayler AB
(2012)
Exploring the origins of turbulence in multiphase flow using compressed sensing MRI.
in Physical review letters
Description | This was a Platform Grant and therefore covered a wide range of method development in magnetic resonance in application to chemical engineering and the process industries. A large number of the projects initiated within this grant are now supported by industrial funding. Research methods which have been continued in such projects include undersampling methods in NMR such as compressed sensing and Bayesian methods; in situ/operando studies of catalysis; and new measurements capabilities at low field. Industrial collaborators include: Johnson Matthey, Shell, Schlumberger, BP and AstraZeneca. |
First Year Of Impact | 2013 |
Sector | Chemicals,Energy,Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Title | Research data supporting "Retaining both discrete and smooth features in 1D and 2D NMR relaxation and diffusion experiments" |
Description | data used in associated publication |
Type Of Material | Database/Collection of data |
Provided To Others? | Yes |
Title | Research data supporting "Study of bubble dynamics in gas-solid fluidized beds using ultrashort echo time (UTE) magnetic resonance imaging (MRI)" |
Description | data associated with paper |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |