The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Aljabali A. A. A.
(2014)
Multimeric microparticles of iron oxide (mMPIO) for dual modality molecular imaging with CT & MRI
in EUROPEAN HEART JOURNAL
Allman SA
(2009)
Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis.
in Chembiochem : a European journal of chemical biology
Baboo S
(2014)
Most human proteins made in both nucleus and cytoplasm turn over within minutes.
in PloS one
Backus KM
(2014)
The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.
in The Journal of biological chemistry
Backus KM
(2011)
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.
in Nature chemical biology
Bagi Zsolt
(2013)
Microparticles bearing RGD peptide promote integrin avß3-dependent platelet adhesion in isolated, pressurized cerebral artery
in FASEB JOURNAL
Barry C
(2013)
'Naked' and Hydrated Conformers of the Conserved Core Pentasaccharide of N-linked Glycoproteins and Its Building Blocks
in Journal of the American Chemical Society
Barry CS
(2011)
ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor.
in Journal of the American Chemical Society
Bernardes GJ
(2011)
Site-selective traceless Staudinger ligation for glycoprotein synthesis reveals scope and limitations.
in Chembiochem : a European journal of chemical biology
Bernardes Goncalo J. L.
(2012)
Building well-defined glycoproteins
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Bernardes Goncalo J. L.
(2012)
Chemical site-selective protein modification: Development of a traceless vascular targeting ADC for cancer therapy
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Boutureira O
(2011)
Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars.
in Chemical communications (Cambridge, England)
Boutureira O
(2010)
Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins.
in Chemical communications (Cambridge, England)
Boutureira O
(2012)
Selenenylsulfide-linked homogeneous glycopeptides and glycoproteins: synthesis of human "hepatic Se metabolite A".
in Angewandte Chemie (International ed. in English)
Boutureira O
(2009)
Accessible sugars as asymmetric olefin epoxidation organocatalysts: glucosaminide ketones in the synthesis of terminal epoxides.
in Organic & biomolecular chemistry
Boutureira Omar
(2012)
Chemical site-selective radiolabelling of proteins using fluorosugars
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Chalker J
(2011)
Methods for converting cysteine to dehydroalanine on peptides and proteins
in Chemical Science
Chalker JM
(2009)
Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine.
in Chemical communications (Cambridge, England)
Chalker JM
(2012)
Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications.
in Angewandte Chemie (International ed. in English)
Chalker JM
(2009)
Chemical modification of proteins at cysteine: opportunities in chemistry and biology.
in Chemistry, an Asian journal
Chalker JM
(2011)
A "tag-and-modify" approach to site-selective protein modification.
in Accounts of chemical research
Chalker JM
(2009)
A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.
in Journal of the American Chemical Society
Chalker JM
(2010)
Chemical mutagenesis: selective post-expression interconversion of protein amino acid residues.
in Current opinion in chemical biology
Chalker Justin M.
(2011)
Suzuki-Miyaura cross-coupling on protein substrates using a novel palladium-pyrimidine catalyst
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Chalker Justin M.
(2011)
Allyl sulfides enable olefin metathesis in water and on proteins
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Chalker Justin M.
(2011)
Reaction engineering for protein modification
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Chang Y-P
(2014)
DISCOVERY OF A SELECTIVE LYSOSOMAL ALPHA-MANNOSIDASE INHIBITOR FROM AN IMINO-SUGAR LIBRARY
in JOURNAL OF PEPTIDE SCIENCE
Chooi K. Phin
(2014)
Giving p38a kinase a jump-start: p38a Activation induced by chemical modification
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Chooi KP
(2014)
Synthetic phosphorylation of p38a recapitulates protein kinase activity.
in Journal of the American Chemical Society
Cobo I
(2012)
Phosphine-free Suzuki-Miyaura cross-coupling in aqueous media enables access to 2-C-aryl-glycosides.
in Organic letters
Cocinero EJ
(2011)
Exploring carbohydrate-peptide interactions in the gas phase: structure and selectivity in complexes of pyranosides with N-acetylphenylalanine methylamide.
in Journal of the American Chemical Society
Cocinero EJ
(2009)
Peptide secondary structures in the gas phase: consensus motif of N-linked glycoproteins.
in Journal of the American Chemical Society
Cocinero EJ
(2009)
Hydration of sugars in the gas phase: regioselectivity and conformational choice in N-acetyl glucosamine and glucose.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Cocinero EJ
(2009)
The building blocks of cellulose: the intrinsic conformational structures of cellobiose, its epimer, lactose, and their singly hydrated complexes.
in Journal of the American Chemical Society
Cocinero EJ
(2013)
Free fructose is conformationally locked.
in Journal of the American Chemical Society
Cocinero EJ
(2011)
Sensing the anomeric effect in a solvent-free environment.
in Nature
Cruz IN
(2013)
Glycomimetic affinity-enrichment proteomics identifies partners for a clinically-utilized iminosugar.
in Chemical science
Davis B
(2009)
A silver-lined anniversary of Fleet iminosugars: 1984-2009, from DIM to DRAM to LABNAc
in Tetrahedron: Asymmetry
Davis B
(2009)
Sugars and proteins: New strategies in synthetic biology
in Pure and Applied Chemistry
Davis Ben
(2012)
Sugars and proteins
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Davis Benjamin G.
(2009)
Sugar and proteins: Strategies in synthetic biology
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Davis BG
(2010)
Enzyme catalysis: sweet flexibility.
in Nature chemistry
Davis BG
(2009)
The linear assembly of a pure glycoenzyme.
in Angewandte Chemie (International ed. in English)
De Munari S
(2015)
A Triply Divergent Reagent for Glycoprotein Synthesis
in Israel Journal of Chemistry
Dickens A. M.
(2009)
PLS models discriminate types of MS from spectroscopic analysis of plasma and urinele
in MULTIPLE SCLEROSIS
Doores K. J.
(2009)
A 'non-self' mimic of the natural epitope of anti-HIV antibody 2G12 shows enhanced antigenicity
in RETROVIROLOGY
Doores KJ
(2010)
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
in Proceedings of the National Academy of Sciences of the United States of America
Dumas A
(2013)
Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.
in Angewandte Chemie (International ed. in English)
Dumas A
(2015)
Designing logical codon reassignment - Expanding the chemistry in biology.
in Chemical science
Díaz-Rodríguez A
(2011)
Chemical modification in the creation of novel biocatalysts.
in Current opinion in chemical biology
Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
Sectors | Education,Pharmaceuticals and Medical Biotechnology |
URL | http://users.ox.ac.uk/~dplb0149/index.html |
Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
First Year Of Impact | 2009 |
Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
Impact Types | Cultural,Societal,Economic,Policy & public services |
Company Name | Glycoform Ltd |
Description | drug delivery and glycoprotein specialist; biopharmaceuticals |
Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |
Website | http://isis-innovation.com/news/glycoform-ltd-improve-drug-delivery/ |