The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Gao Z
(2013)
Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.
in Journal of the American Chemical Society
Davis BG
(2010)
Enzyme catalysis: sweet flexibility.
in Nature chemistry
Barry CS
(2011)
ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor.
in Journal of the American Chemical Society
Cocinero EJ
(2011)
Exploring carbohydrate-peptide interactions in the gas phase: structure and selectivity in complexes of pyranosides with N-acetylphenylalanine methylamide.
in Journal of the American Chemical Society
Hong SY
(2010)
Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging.
in Nature materials
Patel MK
(2010)
Flow chemistry kinetic studies reveal reaction conditions for ready access to unsymmetrical trehalose analogues.
in Organic & biomolecular chemistry
Boutureira O
(2010)
Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins.
in Chemical communications (Cambridge, England)
Schiffner T.
(2013)
Focusing Antibody Responses to Specific Protein Surfaces Through Site-Selective Glycan Addition
in AIDS RESEARCH AND HUMAN RETROVIRUSES
Cocinero EJ
(2013)
Free fructose is conformationally locked.
in Journal of the American Chemical Society
Hong Sung You
(2009)
Functionalization of single walled carbon nanotubes with carbohydrates
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
Sectors | Education,Pharmaceuticals and Medical Biotechnology |
URL | http://users.ox.ac.uk/~dplb0149/index.html |
Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
First Year Of Impact | 2009 |
Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
Impact Types | Cultural,Societal,Economic,Policy & public services |
Company Name | Glycoform Ltd |
Description | drug delivery and glycoprotein specialist; biopharmaceuticals |
Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |
Website | http://isis-innovation.com/news/glycoform-ltd-improve-drug-delivery/ |