Nanoanalysis for Advanced Materials and Healthcare
Lead Research Organisation:
University of Strathclyde
Department Name: Physics
Abstract
This proposal seeks funding to deliver enhanced capability for characterising and assessing advanced nanomaterials using three complementary, leading edge techniques: Field-emission microprobe (EPMA), combined Raman/multiphoton confocal microscope (Raman/MP) and small angle X-ray scattering (SAXS). This suite of equipment will be used to generate a step-change in nanoanalysis capability for a multi-disciplinary team of researchers who together form a key part of Strathclyde's new Technology and Innovation Centre (TIC). The equipment will support an extensive research portfolio with an emphasis on functional materials and healthcare applications. The requested equipment suite will enable Strathclyde and other UK academics to partner with other world-leading groups having complementary analytical facilities, thereby creating an international collaborative network of non-duplicated facilities for trans-national access. Moreover the equipment will generate new research opportunities in advanced materials science in partnership with the National Physical Laboratory, UK industry and academia.
Planned Impact
The creation and exploitation of new technologies for biological and nanoscale material characterization often underpins developments that have a far-reaching impact at multiple levels of society including governmental, academic, the commercial sector, as well as the wider public.
In areas such as developing new nanomaterials for biomedical diagnostic and therapeutic applications, there remains a huge gulf between concept and translation into clinical applications. This equipment will enable studies to be performed with increasing sensitivity, speed and complexity for cell and tissue imaging and time-based measurements. As well as promoting fundamental understanding on how to better diagnose and track disease progress and along side more effective drug and vaccine delivery, this equipment will help address industrial and societal concerns on nanoparticle safety and potential environmental impact.
At a commercial level, potential beneficiaries in the shorter term include companies who are interested in the development and testing of a wide array of different chemical and bionanomaterials for sensing and medical applications. Instrumentation companies who are keen to integrate new technologies such as light sources, detection and imaging equipment for biomedical applications are also potential beneficiaries. During both the instrument facility construction and its subsequent use we will work with our UK-based partners in these areas to demonstrate new measurement and application possibilities.
In the longer term, the ability to demonstrate more effective healthcare technologies has tremendous potential for both society and the generation of new intellectual property. For example, the discovery and rational design of new and more effective materials for medical treatment can be made improved by speeding up the cycle between design and understanding the response at the cellular and tissue level. This will be promoted by utilising less invasive methods capable of faster and more accurate disease monitoring.
In areas such as developing new nanomaterials for biomedical diagnostic and therapeutic applications, there remains a huge gulf between concept and translation into clinical applications. This equipment will enable studies to be performed with increasing sensitivity, speed and complexity for cell and tissue imaging and time-based measurements. As well as promoting fundamental understanding on how to better diagnose and track disease progress and along side more effective drug and vaccine delivery, this equipment will help address industrial and societal concerns on nanoparticle safety and potential environmental impact.
At a commercial level, potential beneficiaries in the shorter term include companies who are interested in the development and testing of a wide array of different chemical and bionanomaterials for sensing and medical applications. Instrumentation companies who are keen to integrate new technologies such as light sources, detection and imaging equipment for biomedical applications are also potential beneficiaries. During both the instrument facility construction and its subsequent use we will work with our UK-based partners in these areas to demonstrate new measurement and application possibilities.
In the longer term, the ability to demonstrate more effective healthcare technologies has tremendous potential for both society and the generation of new intellectual property. For example, the discovery and rational design of new and more effective materials for medical treatment can be made improved by speeding up the cycle between design and understanding the response at the cellular and tissue level. This will be promoted by utilising less invasive methods capable of faster and more accurate disease monitoring.
Organisations
- University of Strathclyde (Lead Research Organisation)
- AstraZeneca (United Kingdom) (Project Partner)
- Defence Science and Technology Laboratory (Project Partner)
- Novartis (Switzerland) (Project Partner)
- Bayer (Germany) (Project Partner)
- General Electric (United Kingdom) (Project Partner)
- University of Glasgow (Project Partner)
- GlaxoSmithKline (United Kingdom) (Project Partner)
- National Physical Laboratory (Project Partner)
- IQE (United Kingdom) (Project Partner)
Publications
Tipping WJ
(2024)
Label-Free Screening of Drug-Induced Liver Injury Using Stimulated Raman Scattering Microscopy and Spectral Phasor Analysis.
in Analytical chemistry
Braddick HJ
(2023)
Determination of Intracellular Esterase Activity Using Ratiometric Raman Sensing and Spectral Phasor Analysis.
in Analytical chemistry
Swiatlowska P
(2023)
Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
in Advanced Science
Tentellino C
(2022)
Ratiometric imaging of minor groove binders in mammalian cells using Raman microscopy
in RSC Chemical Biology
Gaba F
(2022)
Raman Spectroscopy in Prostate Cancer: Techniques, Applications and Advancements
in Cancers
Hunter DA
(2022)
Assessing the Impact of Secondary Fluorescence on X-Ray Microanalysis Results from Semiconductor Thin Films.
in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Tipping W
(2022)
Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug-cell interactions
in Chemical Science
Mukhopadhyay P
(2022)
Role of defects in ultra-high gain in fast planar tin gallium oxide UV-C photodetector by MBE
in Applied Physics Letters
Hislop E
(2022)
Label-Free Imaging of Lipid Droplets in Prostate Cells Using Stimulated Raman Scattering Microscopy and Multivariate Analysis
in Analytical Chemistry
Tipping WJ
(2022)
Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system.
in RSC chemical biology
Khatchenko Y
(2022)
Structural, optical and electronic properties of the wide bandgap topological insulator Bi1.1Sb0.9Te2S
in Journal of Alloys and Compounds
Naresh-Kumar G
(2022)
Non-destructive imaging of residual strains in GaN and their effect on optical and electrical properties using correlative light-electron microscopy
in Journal of Applied Physics
Spasevski L
(2021)
Quantification of Trace-Level Silicon Doping in Al x Ga1-xN Films Using Wavelength-Dispersive X-Ray Microanalysis.
in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Hatipoglu I
(2021)
Correlation between deep-level defects and functional properties of ß-(Sn x Ga1- x )2O3 on Si photodetectors
in Journal of Applied Physics
Wilson LT
(2021)
Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH.
in Analytical chemistry
Mukhopadhyay P
(2021)
High Figure-of-Merit Gallium Oxide UV Photodetector on Silicon by Molecular Beam Epitaxy: A Path toward Monolithic Integration
in Advanced Photonics Research
Sulimov M
(2021)
Effects of irradiation of ZnO/CdS/Cu2ZnSnSe4/Mo/glass solar cells by 10 MeV electrons on photoluminescence spectra
in Materials Science in Semiconductor Processing
Hasan A
(2020)
Surface Design for Immobilization of an Antimicrobial Peptide Mimic for Efficient Anti-Biofouling.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Amano H
(2020)
The 2020 UV emitter roadmap
in Journal of Physics D: Applied Physics
Foronda H
(2020)
Electrical properties of (11-22) Si:AlGaN layers at high Al contents grown by metal-organic vapor phase epitaxy
in Applied Physics Letters
Bruckbauer J
(2020)
Luminescence behavior of semipolar (101¯1) InGaN/GaN "bow-tie" structures on patterned Si substrates
in Journal of Applied Physics
Wilson LT
(2020)
A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy.
in The Analyst
Spasevski L
(2020)
A systematic comparison of polar and semipolar Si-doped AlGaN alloys with high AlN content
in Journal of Physics D: Applied Physics
Walde S
(2020)
AlN overgrowth of nano-pillar-patterned sapphire with different offcut angle by metalorganic vapor phase epitaxy
in Journal of Crystal Growth
Armstrong R
(2020)
Creation of regular arrays of faceted AlN nanostructures via a combined top-down, bottom-up approach
in Journal of Crystal Growth
Description | New state-of-the art equipment purchased, installed and operational (mid-2017) |
Exploitation Route | Access to equipment for nanoanalysis (electron microprobe, small angle X-ray scattering and multi-photon Raman microscopy) |
Sectors | Electronics Energy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
Description | The equipment is fully operational and performing well. A wide range of experimental data is being produced to support academic collaborations and industrial users. We have demonstrated a range of new ways of measuring that are useful in a number of non-academic contexts, such as understanding the composition and optical emission from various semiconductor materials and structures. A series of journal publications describe how the capabilities of the equipment have been employed in different contexts. A number (approx. 7) PhD students have graduated with expertise in using the equipment. Two of these have gone on to work for UK companies making materials characterisation equipment and one to a US-based measurement company. A range of non-academic users (approx. 10 different companies) have contracted work to be performed using the equipment |
First Year Of Impact | 2018 |
Sector | Aerospace, Defence and Marine,Chemicals,Digital/Communication/Information Technologies (including Software),Education,Electronics,Energy,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
Impact Types | Societal Economic |
Title | Data for: "A systematic comparison of polar and semipolar Si-doped AlGaN alloys with high AlN content" |
Description | This data is the result of cathodoluminescence hyperspectral imaging and wavelength-dispersive X-ray spectroscopy measurements carried out on a set of Si-doped Al?Ga1??N epilayers, grown at the Tyndall Institute using different AlGaN crystal orientations and Si incorporation. Further analysis and interpretation of this data is presented in the associated journal article, and figure numbers referred to in the data correspond to those used in this paper: "A systematic comparison of polar and semipolar Si-doped AlGaN alloys with high AlN content" by L. Spasevski et al (2020), Journal of Physics D: Applied Physics. DOI: 10.1088/1361-6463/abbc95 |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://pureportal.strath.ac.uk/en/datasets/d7c54205-9bca-4785-9b3e-1e6a2b182771 |