Tackling human dental caries by multi-modal correlative microscopy and multi-physics modelling
Lead Research Organisation:
University of Oxford
Department Name: Engineering Science
Abstract
Human mineralised dental tissues are the hardest tissues in the human body that represent an intriguing example of nature's hierarchical engineering across the scales, from the atomic level assembly of naturally grown hydroxyapatite crystals during amelo- and dentino-genesis to their incorporation into organic matrix nano-composite and the growth into macroscopic teeth that fulfil a complex long-term role crucial to the existence and well-being of every human being on the planet. It is a shining example of nature's design fit for purpose. However, in the instance of human dental caries, the combination of modern sugar-rich diet, plaque-forming bacteria and demineralisation caused by the acidic environment they produce defeats the intricate evolutionary process. In industrialized countries, dental caries affects 60-90% of schoolchildren and the vast majority of adults, remaining one of the most persistent and challenging diseases causing pain, suffering and upset. Although progress in controlling this disease by water fluoridation is well documented, in most cases dentist's instructions focus on recommendations for changes in the lifestyle and oral hygiene, in practice turning out to have limited efficiency. According to the latest (2016) report of the UK's Health and Social Care Information Centre (HSCIC), tooth decay in English children has been steadily rising for four years in a row. These alarming figures reported in national news headlines (www.bbc.co.uk/news/health-35672775) bring this research topic into sharp focus, meaning that the outcomes of the proposed project are likely to make notable scientific and societal impact.
In this proposal we wish to tackle the caries challenge by undertaking a systematic, coordinated, multi-scale microscopic investigation, coupled with numerical disease modelling to move towards better diagnosis, and proactive intervention and treatment of caries. By applying this joined-up, cross-correlated analytical approach to the same samples by the specialists in nano-scale multi-modal microscopy and modeling (Oxford) and dental research and teaching (Birmingham), we will establish a tight connection between ultrastructural, chemical and compositional changes seen by FIB-SEM and advanced X-ray methods, and the patterns, colours, signals and signs observable by conventional dentistry techniques. The proposers have extensive partnership links with university and large facility research groups, dental companies and practicing dentists across the globe. Involvement of OHI Ltd. and Specialists Dental Group as partners, and the secured support from Tescan and Diamond Light Source (DLS) will increase and accelerate impact. This will pave a practical and efficient way to new interpretative approaches and treatment routines. We will bridge the insights from nano-scale characterization to conventional dentistry techniques (X-ray radiography and histology). We will build a multi-scale model that will serve as a predictive tool to guide the formulation of the most promising strategies for overcoming caries.
The project objectives are closely aligned with all aspects of EPSRC Healthcare Technologies Grand Challenges, answering the topics of developing future therapies, controlling the amount of physical intervention required, optimizing treatment, and transforming community health and care. In parallel, we shall contribute to the advancement of Cross-Cutting Research Capabilities that are essential for delivering these Grand Challenges. In particular, this research will develop novel imaging technologies employing multi-modal microscopy, and use the insights obtained to create novel approaches in computational and mathematical sciences through the formulation and validation of sophisticated numerical models of disease and treatment. The work will also benefit the areas of advanced materials and disruptive technologies for sensing and analysis.
In this proposal we wish to tackle the caries challenge by undertaking a systematic, coordinated, multi-scale microscopic investigation, coupled with numerical disease modelling to move towards better diagnosis, and proactive intervention and treatment of caries. By applying this joined-up, cross-correlated analytical approach to the same samples by the specialists in nano-scale multi-modal microscopy and modeling (Oxford) and dental research and teaching (Birmingham), we will establish a tight connection between ultrastructural, chemical and compositional changes seen by FIB-SEM and advanced X-ray methods, and the patterns, colours, signals and signs observable by conventional dentistry techniques. The proposers have extensive partnership links with university and large facility research groups, dental companies and practicing dentists across the globe. Involvement of OHI Ltd. and Specialists Dental Group as partners, and the secured support from Tescan and Diamond Light Source (DLS) will increase and accelerate impact. This will pave a practical and efficient way to new interpretative approaches and treatment routines. We will bridge the insights from nano-scale characterization to conventional dentistry techniques (X-ray radiography and histology). We will build a multi-scale model that will serve as a predictive tool to guide the formulation of the most promising strategies for overcoming caries.
The project objectives are closely aligned with all aspects of EPSRC Healthcare Technologies Grand Challenges, answering the topics of developing future therapies, controlling the amount of physical intervention required, optimizing treatment, and transforming community health and care. In parallel, we shall contribute to the advancement of Cross-Cutting Research Capabilities that are essential for delivering these Grand Challenges. In particular, this research will develop novel imaging technologies employing multi-modal microscopy, and use the insights obtained to create novel approaches in computational and mathematical sciences through the formulation and validation of sophisticated numerical models of disease and treatment. The work will also benefit the areas of advanced materials and disruptive technologies for sensing and analysis.
Planned Impact
In terms of the economic and societal impact, the principal project outcomes will have far-reaching implications in health and lifestyle, social policy and commerce, leading to drastic improvements in the quality of life and state of health, and contributing to personal happiness of many people. UK enjoys a leading position in many aspects of medical research, with therapies and approaches developed here successfully adopted across the globe. Each new major advance taken up by UK practitioners and health technology companies gets progressively accepted and used in Singapore Australia, US, Japan, and many other countries. Leading new treatment development brings tangible economic benefits to UK. Outcomes of this project will change the formulation of dental rinses and toothpastes (global market of ~$12.5bn, topping dental implants market of ~$8bn). Also affected will be the dental consumables market including filling restorative materials and adhesives approaches ~$20bn worldwide. Overall, long-term emphasis shift will be from routine caries treatment to prosthodontics and functional restoration procedures.
For knowledge impact, the integrative paradigm of tight combination of cutting edge characterisation techniques with advanced multi-physics modelling will elucidate the course of disease and treatment across the scales, and deliver crucial understanding and ability to control the disease in a targeted and bespoke fashion. Cross-fertilisation between disciplines of multi-modal microscopy and dental therapy will attract more researchers with physical sciences background to the study of biological tissues and treatments. Advancing novel approaches to structural and compositional analysis of human tissues will be used to study other mineralised tissues, such as bone; Advances in microscopy (X-ray) techniques will benefit major partners and collaborators active in the field, such as Tescan and Oxford Instruments, DLS and RCaH, and smaller entities (Deben Research, Alemnis and WITec). These connections will ensure that progress achieved in experimental technique development will become embodied in publicly and commercially available setups and instruments, benefitting numerous researchers in the field; Dissemination of outcomes to industrial and academic researchers of modelling activities will enhance the general level of awareness and understanding in the field, and become available in the form of software packages, such as Matlab, Mathematica, and Abaqus.
For translation from research into practice, it will put new insights from nano-scale imaging into the context of evidence from more widespread methods of oral histology, radiography and spectral imaging, making them directly accessible to practitioners such as project partners: Specialists Dental Group, Singapore, Oral Health Innovation Ltd in Birmingham, UK. In addition, the links with dental supplies companies, such as Ivoclar Vivadent, GSK Oral Healthcare will be maintained and developed. Patent applications will be made through Oxford and Birmingham university IPR companies.
For human capital, this project will educate post-doctoral researchers in a complex, multi-faceted, multi-disciplinary project. Dr Tan Sui already fulfils the role of manager for the group electron microscopy (MBLEM) and X-ray diffraction and imaging (HEX) facilities. This project will contribute to her experience, and provide an excellent foundation for her to seek a permanent post in academia. Final year undergraduate students of BMedSc (Birm) and MEng (Ox) will benefit from being exposed to cutting edge research challenges, and may continue towards doctoral study. We will welcome visiting students from collaborating institutions across Europe.
Broader dissemination of our scientific results will take place through specialised workshops and active publication in periodicals such as Nature Communications, Acta Biomaterialia, J Dental Research, and Materials & Design that PI and RCI co-edit.
For knowledge impact, the integrative paradigm of tight combination of cutting edge characterisation techniques with advanced multi-physics modelling will elucidate the course of disease and treatment across the scales, and deliver crucial understanding and ability to control the disease in a targeted and bespoke fashion. Cross-fertilisation between disciplines of multi-modal microscopy and dental therapy will attract more researchers with physical sciences background to the study of biological tissues and treatments. Advancing novel approaches to structural and compositional analysis of human tissues will be used to study other mineralised tissues, such as bone; Advances in microscopy (X-ray) techniques will benefit major partners and collaborators active in the field, such as Tescan and Oxford Instruments, DLS and RCaH, and smaller entities (Deben Research, Alemnis and WITec). These connections will ensure that progress achieved in experimental technique development will become embodied in publicly and commercially available setups and instruments, benefitting numerous researchers in the field; Dissemination of outcomes to industrial and academic researchers of modelling activities will enhance the general level of awareness and understanding in the field, and become available in the form of software packages, such as Matlab, Mathematica, and Abaqus.
For translation from research into practice, it will put new insights from nano-scale imaging into the context of evidence from more widespread methods of oral histology, radiography and spectral imaging, making them directly accessible to practitioners such as project partners: Specialists Dental Group, Singapore, Oral Health Innovation Ltd in Birmingham, UK. In addition, the links with dental supplies companies, such as Ivoclar Vivadent, GSK Oral Healthcare will be maintained and developed. Patent applications will be made through Oxford and Birmingham university IPR companies.
For human capital, this project will educate post-doctoral researchers in a complex, multi-faceted, multi-disciplinary project. Dr Tan Sui already fulfils the role of manager for the group electron microscopy (MBLEM) and X-ray diffraction and imaging (HEX) facilities. This project will contribute to her experience, and provide an excellent foundation for her to seek a permanent post in academia. Final year undergraduate students of BMedSc (Birm) and MEng (Ox) will benefit from being exposed to cutting edge research challenges, and may continue towards doctoral study. We will welcome visiting students from collaborating institutions across Europe.
Broader dissemination of our scientific results will take place through specialised workshops and active publication in periodicals such as Nature Communications, Acta Biomaterialia, J Dental Research, and Materials & Design that PI and RCI co-edit.
Organisations
- University of Oxford (Lead Research Organisation)
- Specialist Dental Group (Collaboration, Project Partner)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- DIAMOND LIGHT SOURCE (Collaboration)
- Diamond Light Source (Project Partner)
- Tescan UK Ltd (Project Partner)
- Oral Health Innovations Limited (Project Partner)
Publications
Sui T
(2017)
Strain softening of nano-scale fuzzy interfaces causes Mullins effect in thermoplastic polyurethane.
in Scientific reports
Romano Brandt L
(2017)
Probing the deformation and fracture properties of Cu/W nano-multilayers by in situ SEM and synchrotron XRD strain microscopy
in Surface and Coatings Technology
Salvati E
(2017)
An analysis of macro- and micro-scale residual stresses of Type I, II and III using FIB-DIC micro-ring-core milling and crystal plasticity FE modelling
in International Journal of Plasticity
Fleury R
(2017)
Characterisation of handling and service surface damage on Nickel alloys caused by low velocity impacts of blunt hard objects
in Mechanics of Materials
Robinson I
(2017)
Materials & Design Virtual Special Issue Editorial: Analysis of material microstructure and defects using X-ray and neutron beams - Size-Strain
in Materials & Design
Lunt A
(2017)
Characterisation of nanovoiding in dental porcelain using small angle neutron scattering and transmission electron microscopy.
in Dental materials : official publication of the Academy of Dental Materials
Sheng Y
(2017)
Photoluminescence Segmentation within Individual Hexagonal Monolayer Tungsten Disulfide Domains Grown by Chemical Vapor Deposition.
in ACS applied materials & interfaces
Salvati E
(2017)
Eigenstrain reconstruction of residual strains in an additively manufactured and shot peened nickel superalloy compressor blade
in Computer Methods in Applied Mechanics and Engineering
Kirkwood H
(2017)
High resolution imaging and analysis of residual elastic strain in an additively manufactured turbine blade
in International Journal of Nanotechnology
Sebastiani M
(2017)
Residual stress evaluation at the micro- and nano-scale: Recent advancements of measurement techniques, validation through modelling, and future challenges
in Materials & Design
Pandey A
(2017)
In situ and operando studies of structural and functional materials and systems using electron, ion and X-ray microscopy
in Materials & Design
Salvati E
(2017)
Separating plasticity-induced closure and residual stress contributions to fatigue crack retardation following an overload
in Journal of the Mechanics and Physics of Solids
Sui T
(2018)
Structure-Function Correlative Microscopy of Peritubular and Intertubular Dentine.
in Materials (Basel, Switzerland)
Sui T
(2018)
In situ monitoring and analysis of enamel demineralisation using synchrotron X-ray scattering.
in Acta biomaterialia
Lunt A
(2018)
On the origins of strain inhomogeneity in amorphous materials
in Scientific Reports
Sui T
(2019)
Multiscale synchrotron scattering studies of the temperature-dependent changes in the structure and deformation response of a thermoplastic polyurethane elastomer
in Materials Today Advances
Kan Y.
(2019)
On the fabrication of diatomite earth-based ceramics with multiscale porosity
in Lecture Notes in Engineering and Computer Science
Uzun F
(2019)
The height Digital Image Correlation (hDIC) technique for the identification of triaxial surface deformations
in International Journal of Mechanical Sciences
Ast J
(2019)
A review of experimental approaches to fracture toughness evaluation at the micro-scale
in Materials & Design
Salvati E
(2019)
Crack Tip Stress Field Analysis of Crack Surface Contact and Opening during <i>In Situ</i> Wedge Loading of Human Enamel
in Key Engineering Materials
Korsunsky A
(2019)
Nature's neat nanostructuration
in Materials Today
Abdusatorov B.
(2019)
On the prospects of using Biogenic Silica for MEMS (Micro-Electro-Mechanical Systems)
in Lecture Notes in Engineering and Computer Science
Kan Y.
(2019)
Collagen-based Composite and Hybrid Bone Implant Materials: Structure and Property Characterization
in Lecture Notes in Engineering and Computer Science
Sui T
(2019)
Probing the complex thermo-mechanical properties of a 3D-printed polylactide-hydroxyapatite composite using in situ synchrotron X-ray scattering.
in Journal of advanced research
Korsunsky A
(2020)
Pyrite 'poste restante'
in Materials Today
Salvati E
(2020)
An analysis of fatigue failure mechanisms in an additively manufactured and shot peened IN 718 nickel superalloy
in Materials & Design
Salvati E
(2020)
Micro-scale measurement & FEM modelling of residual stresses in AA6082-T6 Al alloy generated by wire EDM cutting
in Journal of Materials Processing Technology
Wang Z
(2020)
Evolution of thermal and mechanical properties of Nitinol wire as a function of ageing treatment conditions
in Journal of Alloys and Compounds
Romano Brandt L
(2020)
Synchrotron X-ray quantitative evaluation of transient deformation and damage phenomena in a single nickel-rich cathode particle
in Energy & Environmental Science
Kan Y
(2020)
The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch
in Materials Today Communications
Harper RA
(2021)
Acid-induced demineralisation of human enamel as a function of time and pH observed using X-ray and polarised light imaging.
in Acta biomaterialia
Besnard C
(2021)
3D analysis of enamel demineralisation in human dental caries using high-resolution, large field of view synchrotron X-ray micro-computed tomography
in Materials Today Communications
Salvati E
(2021)
Finite Element Modelling and Experimental Validation of the Enamel Demineralisation Process at the Rod Level.
in Journal of advanced research
Romano Brandt L
(2021)
Stress-Assisted Thermal Diffusion Barrier Breakdown in Ion Beam Deposited Cu/W Nano-Multilayers on Si Substrate Observed by in Situ GISAXS and Transmission EDX.
in ACS applied materials & interfaces
Wang Z
(2021)
In situ neutron diffraction investigation of texture-dependent Shape Memory Effect in a near equiatomic NiTi alloy
in Acta Materialia
Romano Brandt L
(2022)
Improving ultra-fast charging performance and durability of all solid state thin film Li-NMC battery-on-chip systems by in situ TEM lamella analysis
in Applied Materials Today
Besnard C
(2022)
Hierarchical 2D to 3D micro/nano-histology of human dental caries lesions using light, X-ray and electron microscopy
in Materials & Design
Besnard C
(2022)
Nanoscale correlative X-ray spectroscopy and ptychography of carious dental enamel
in Materials & Design
Hsu CC
(2022)
Increased connectivity of hiPSC-derived neural networks in multiphase granular hydrogel scaffolds.
in Bioactive materials
Besnard C
(2023)
Time-Lapse In Situ 3D Imaging Analysis of Human Enamel Demineralisation Using X-ray Synchrotron Tomography.
in Dentistry journal
Besnard C
(2023)
Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review.
in Dentistry journal
Tricarico M
(2023)
Stress-strain relationships and yielding of metal-organic framework monoliths
in Communications Materials
Besnard C
(2023)
Multi-resolution Correlative Ultrastructural and Chemical Analysis of Carious Enamel by Scanning Microscopy and Tomographic Imaging.
in ACS applied materials & interfaces
Description | Key findings are: - the development of experimental procedures for in vitro, in situ synchrotron analysis of enamel erosion - the development of the initial 'whole disease' multi-physics model - the development of procedures for model tuning and cross-validation against experiments, including with some time-lapse observation of evolution This has been advanced and extended significantly over the reporting period, with several experiments conducted, results interpreted, and some already published. |
Exploitation Route | Through publication and dissemination of results and methods, they become available to UK and international community. Follow-on grant application is being prepared. |
Sectors | Healthcare |
URL | https://www.dentalreview.news/people/58-dentistry-interviews/3084-professor-korsunky-explores-the-potential-reversal-of-tooth-decay |
Description | Prof Korsunsky's initial interest in studying dental tissues arose from his wish to explore the mechanics of these materials - starting with how enamel and dentine respond to chewing forces. He was also keen to understand their structure and composition, and how they enable these tissues to perform a complex range of demanding functions under extreme conditions in the oral cavity for decades on end. Enamel is an example of a hierarchically structured material built by nature from a brittle ceramic component (hydroxyapatite) in the form of nanoparticles of various shapes and orientations that are glued together with organic matter into micron-sized features, ultimately forming a tissue with fascinating overall properties. Early studies of mineralized dental tissues showed that they are remarkably resilient and resistant to failure, unless afflicted with construction flaws caused by genetic disorders, or attacked by acids in the course of caries. In fact, it was the recognition of the tremendous destructive impact of caries that led Prof Korsunsky to embark on this project. It quickly became apparent that nanoscale events during the damage evolution process were difficult to visualise and understand using traditional dental techniques such as X-ray radiography and surface examination, but they could be elucidated by advanced microscopy and synchrotron X-ray techniques. To study the evolution of caries at all levels, the Oxford team are collaborating with the School of Dentistry at the University of Birmingham. "We were particularly eager to link our research with practical dentistry, so that our findings made at finer scales had a good chance of being passed on into practice," Prof Korsunsky explained. "We wanted to be fully aware of the practicalities and the range of tools available to dentists in a surgery, to ensure that our work is transferable. "Now we can cross-correlate our findings with the data obtained using well-trusted and established techniques, such as histology and laboratory X-ray tomography. One of our aims is to see if we can learn to read the signs of caries progression with conventional dental methods." When a caries lesion first forms on the surface and propagates sub-surface into the enamel, hydroxyapatite is dissolved, and the mineral density is reduced. "Human saliva contains calcium and phosphate ions needed to re-build hydroxyapatite, so the saliva-facing surface of the enamel gets remineralized - but it is not structured in the same way as the original surface," warned Prof Korsunsky. "Once a surface is repaired in this way, the sub-surface layers of the lesion become harder to reach for the ions and remain compromised, until eventually the lesion collapses to expose a cavity. We wanted to know if we could intervene in this process to help remineralization from the bottom up, instead of top down." Now a quarter of the way through this long-term project, Prof Korsunsky and his team have already made some headway. Initially, they built a computer model of the dissolution (erosion) of dental tissues by caries to explain the connection between structural changes and mechanics. Simulating the process in this way suggested that it may be possible to slow down or even reverse the process. Diamond Light Source Some of the key experimental studies were conducted at the synchrotron facility in Oxfordshire called Diamond Light Source (top). The synchrotron acts like a giant microscope, firing electrons at almost the speed of light around a large ring, and utilising powerful light emitted by them as they travel. Prof Korsunsky described the importance of this advanced research tool: "Synchrotron light has the advantage that it allows one to perform most complex in vitro experiments. We can adjust the resolution, going from fractions of a millimetre down to sub-micron beams to probe what is happening across the scales. The beam brings out a variety of information pertaining to the structure and mechanics of the tissue, so we can look at the changes in the crystal size, orientation, and composition of the mineral and organic fractions over time. "We are particularly lucky to receive great support from colleagues at beamline B16 and the Optics and Metrology group at Diamond, which allows us to continue trying out new experimental configurations and obtaining fresh insights." So far, Prof Korsunsky's team found correlations between acidity levels and the rate of lesion progression into the tissue, and how the concentration and type of acid affect the reformation of enamel. The team are now working towards setting up an 'artificial mouth', a device that can reproduce the bacterial, chemical and mechanical effects to mimic the process of caries. "We will carry out experiments that attempt to control remineralization. Our ultimate goal is to understand at the microbial, chemical and nano-mechanical levels how we can guide remineralization so that caries lesions are repaired by natural processes. By understanding the conditions needed to reverse caries, we hope to figure out ultimately how to make this happen in vivo," clarified Prof Korsunsky. "The work at Diamond is already helping us improve our understanding of tooth decay. With the input from dentistry specialists, favourable conditions will be sought that can to stave off decay, or even reverse it. Could the dentist's drill become a thing of the past if nature's inclination to repair can be encouraged?" Professor Alexander Korsunsky has an established track record in gaining insights into the strains and stresses in complex natural and engineered materials, from advanced metallic aerospace alloys to polymers, ceramics, and composites. Several years ago he turned his attention to human dental tissues, enamel and dentine. Together with his team of researchers working at University of Oxford and Diamond Light Source (Harwell, Oxfordshire), he has been able to shed some light on the way in which these hierarchically structured materials respond to mechanical and thermal loading. Now part-way through a project funded by the Engineering and Physical Sciences Research Council (EPSRC), their focus is set on the process of demineralization and remineralization during caries. The team hope to figure out whether it is possible to prevent or reverse decay by relying on the natural ability of our bodies for self-repair. |
First Year Of Impact | 2018 |
Sector | Healthcare |
Impact Types | Societal,Policy & public services |
Description | Opinion expressed in an interview on the most promising directions for treatment of dental caries |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
URL | https://www.dentalreview.news/people/58-dentistry-interviews/3084-professor-korsunky-explores-the-po... |
Description | Elucidating the pathways for human tooth enamel mineralisation by 4D microscopy and microfluidics |
Amount | £2,310,796 (GBP) |
Funding ID | EP/W009412/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2023 |
End | 03/2027 |
Description | MT15981-1 Demineralisation in human dentinal tubules analysis by in situ X-ray scattering |
Amount | £100,000 (GBP) |
Funding ID | MT15981-1 |
Organisation | Diamond Light Source |
Sector | Private |
Country | United Kingdom |
Start | 06/2017 |
End | 06/2017 |
Description | MT19192-1 Operando SAXS/WAXS characterization of demineralisation front in human dental enamel |
Amount | £100,000 (GBP) |
Funding ID | MT19192-1 |
Organisation | Diamond Light Source |
Sector | Private |
Country | United Kingdom |
Start | 04/2018 |
End | 05/2018 |
Title | In situ, in vitro observation of enamel erosion using synchrotron X-ray beam |
Description | We developed the approach - previously not found in the literature - to set up in vitro enamel erosion on synchrotron beam line at Diamond, with simultaneous X-ray imaging and small/wide angle scattering (SAXS/WAXS). |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | This approach was described in publicly available beamtime report on DLS system. It was also presented in the User Working Group meeting at DLS devoted to the design and building of the next generation instrument. |
Description | Birmingham Dental School |
Organisation | University of Birmingham |
Department | School of Dentistry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We advise colleagues at Birmingham School of Dentistry on modern nanoscale characterisation techniques, and implications of these novel approaches for clinical, diagnostic, therapeutic and prosthetic dentistry. |
Collaborator Contribution | We work closely with Birmingham School of Dentistry who provide access to expertise in clinical, diagnostic, therapeutic and prosthetic dentistry, and supply samples for our microscopy and X-ray studies. |
Impact | Multiple publications, joint designs of experiments |
Description | DLS |
Organisation | Diamond Light Source |
Country | United Kingdom |
Sector | Private |
PI Contribution | We provide scientific leadership, ideas for tests, expertise and manpower for running complex experiments. |
Collaborator Contribution | Access to unique world class synchrotron beam lines. |
Impact | Multi-disciplinary - engineering, physics, chemistry; use of X-ray scattering, spectroscopy, imaging |
Description | Specialist Dental Group, Singapore |
Organisation | Specialist Dental Group |
Country | Singapore |
Sector | Hospitals |
PI Contribution | Presentations were made by AMK (PI) at events and meetings in Singapore during which the details of the insights into caries processes obtained in the course of the project were presented. |
Collaborator Contribution | During mutual visits of TKN to UK, and AMK (PI) to Singapore; joint preparation of publications was undertaken, as well as exchange of knowledge and expertise. In particular, advice was received from NTK on caries therapy procedures in Singapore. |
Impact | Publications as found in the literature, preparation of patent applications |
Start Year | 2010 |
Description | Interview with a popular online magazine "Dental Reviews" - https://www.dentalreview.news/people/58-dentistry-interviews/3084-professor-korsunky-explores-the-potential-reversal-of-tooth-decay |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | AMK (PI) was interviewed by a science writer and an article produced: https://www.dentalreview.news/people/58-dentistry-interviews/3084-professor-korsunky-explores-the-potential-reversal-of-tooth-decay |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.dentalreview.news/people/58-dentistry-interviews/3084-professor-korsunky-explores-the-po... |
Description | Public Engagement with Research (PER) Seed Fund |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Public outreach - modern dentistry for healthier teeth |
Year(s) Of Engagement Activity | 2020 |