Newcastle Confidence in Concept 2015

Lead Research Organisation: Newcastle University


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Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


10 25 50

Description Examining efficacy of a novel bromodomain inhibitor AZD5153 in castrate resistant prostate cancer (MRC)
Amount £313,973 (GBP)
Funding ID MR/P009972/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 01/2020
Description Heriot Watt University EPSRC IAA
Amount £27,600 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Description Improved conjugate vaccines derived from bacterial immunomodulatory protein
Amount £238,883 (GBP)
Funding ID BB/N022165/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 07/2018
Title Gas-Phase Fluorescence Analysis 
Description The aim of the project is to ready our breath-acetone device prototype for use in human subjects and to collect performance data so that we will be in a position to apply for external funding to conduct a series of clinical investigations designed to establish the potential role of the device in a range of clinical settings. Such positioning requires that the performance of the device be optimised and its accuracy be validated by comparing measurements with the gold-standard measuring technique, gas chromatography. Once the accuracy of the device has been confirmed we will install online breath-sampling capability for passive acetone-concentration measurements on humans in real time. 
IP Reference PCT/EP2016/068471 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact N/A
Title Immunogenic compositions comprising Sbi protein and uses thereof 
Description pro-vaccine adjuvant SCOF ability to enhance the potency of immunisation of a candidate mycobacterium tuberculosis vaccine 
IP Reference 1619965.5 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact builds on existing data to confirm that SCOF can induce improved/lasting immune cell memory. ability to function cross-species.