Newcastle Confidence in Concept 2015

Lead Research Organisation: Newcastle University

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

10 25 50

 
Description 3D hiPSC derived laminated retina model as a tool for toxicology studies
Amount £1,000,000 (GBP)
Funding ID NC/C016106/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 10/2020
 
Description Adjunctive vagus nerve stimulation for improving gait in Parkinson's Disease (AdVaNSING-PD)
Amount £128,048 (GBP)
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
 
Description Assessing the feasibility of induced pluripotent stem cells to provide a disease model for Retinoblastoma
Amount £169,982 (GBP)
Funding ID 5095/5096 
Organisation Fight for Sight 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 09/2021
 
Description Clinical Academic Research Partnership (CARP) award - Novel MRI Biomarkers in Neuromuscular Disease
Amount £146,625 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2019 
 
Description Confidence in Concept 2016 - Cell surface marking of corneal epithelial stem cells: a powerful approach to stem cell enrichment prior to transplantation
Amount £59,664 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2018
 
Description DESIGN AND PRODUCTION OF A COMMERCIAL PROTOTYPE OF A BREATH-ACETONE ANALYSER TO IMPROVE TREATMENT OF CHILDREN WITH LIFE-THREATENING DIABETIC KETOACIDOSIS
Amount £49,200 (GBP)
Organisation Durham University 
Sector Academic/University
Country United Kingdom
Start  
 
Description Development of a novel imaging method "Motor Unit Magnetic Resonance Imaging" (MUMRI) to investigate motor unit activity in ageing.
Amount £165,672 (GBP)
Funding ID NIHRBRC14 
Organisation National Institute for Health Research 
Department NIHR Newcastle Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Examining efficacy of a novel bromodomain inhibitor AZD5153 in castrate resistant prostate cancer (MRC)
Amount £313,973 (GBP)
Funding ID MR/P009972/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Heriot Watt University EPSRC IAA
Amount £27,600 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Improved conjugate vaccines derived from bacterial immunomodulatory protein
Amount £238,883 (GBP)
Funding ID BB/N022165/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 07/2018
 
Description MR imaging of motor unit dynamics as a non-invasive disease biomarker in spinal muscular atrophy
Amount £218,566 (GBP)
Funding ID 18GRO-PG36-0246 
Organisation Muscular Dystrophy UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2022
 
Description NWO Rubicon Fellowship - Motor unit assessment with magnetic resonance imaging. A new way to measure and understand the pathophysiology behind amyotrophic Iateral sclerosis
Amount £154,220 (GBP)
Organisation NWO Rubicon Fellowship 
Sector Private
Country Netherlands
Start 02/2020 
 
Description RNA helicase DDX3X regulates JAK-STAT signalling in acute lymphoblastic leukaemia
Amount £100,580 (GBP)
Organisation Children's Cancer and Leukaemia Group (CCLG) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description RfPB A systematic review of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes
Amount £144,908 (GBP)
Funding ID P21533 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 08/2017 
End 09/2018
 
Title Gas-Phase Fluorescence Analysis 
Description The aim of the project is to ready our breath-acetone device prototype for use in human subjects and to collect performance data so that we will be in a position to apply for external funding to conduct a series of clinical investigations designed to establish the potential role of the device in a range of clinical settings. Such positioning requires that the performance of the device be optimised and its accuracy be validated by comparing measurements with the gold-standard measuring technique, gas chromatography. Once the accuracy of the device has been confirmed we will install online breath-sampling capability for passive acetone-concentration measurements on humans in real time. 
IP Reference WO2017021424 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact N/A
 
Title Immunogenic compositions comprising Sbi protein and uses thereof 
Description pro-vaccine adjuvant SCOF ability to enhance the potency of immunisation of a candidate mycobacterium tuberculosis vaccine 
IP Reference GB1619965.5 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact builds on existing data to confirm that SCOF can induce improved/lasting immune cell memory. ability to function cross-species.