Newcastle Confidence in Concept 2015

Lead Research Organisation: Newcastle University
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

People

ORCID iD

Publications

10 25 50

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Birkbeck MG (2020) Non-invasive imaging of single human motor units. in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

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Chichagova V (2019) Differentiation of Retinal Organoids from Human Pluripotent Stem Cells. in Current protocols in stem cell biology

 
Description 3D hiPSC derived laminated retina model as a tool for toxicology studies
Amount £1,000,000 (GBP)
Funding ID NC/C016106/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Public
Country United Kingdom
Start 11/2017 
End 10/2020
 
Description A new way to do motoneuron disease research
Amount £1,011,726 (GBP)
Organisation The William Leech Charity 
Sector Charity/Non Profit
Start 04/2018 
End 03/2021
 
Description A single cell sequencing approach to determine the heterogeneity, dynamics and cell fate decisions of retinal progenitor cells in vivo and in vitro
Amount £917,013 (GBP)
Funding ID BB/T004460/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2023
 
Description Adjunctive vagus nerve stimulation for improving gait in Parkinson's Disease (AdVaNSING-PD)
Amount £128,048 (GBP)
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
 
Description Assessing SARS-CoV-2 entry, replication and prevention in a primary human conjunctival cell model and organ cultured cornea/conjunctiva.
Amount £195,489 (GBP)
Funding ID BB/V01126X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 02/2022
 
Description Assessing the feasibility of induced pluripotent stem cells to provide a disease model for Retinoblastoma
Amount £169,982 (GBP)
Funding ID 5095/5096 
Organisation Fight for Sight 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 09/2021
 
Description CX3CR1 antagonist to prevent ischemia/reperfusion injury in patients undergoing primary PCI for STEMI
Amount £1,700,010 (GBP)
Organisation Kancera 
Sector Private
Country Sweden
Start 02/2021 
 
Description Clinical Academic Research Partnership (CARP) award - Novel MRI Biomarkers in Neuromuscular Disease
Amount £146,625 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2019 
 
Description Commercialisation of a Breath-Acetone Sensor
Amount £50,000 (GBP)
Organisation SETsquared Partnership 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Confidence in Concept 2016 - Cell surface marking of corneal epithelial stem cells: a powerful approach to stem cell enrichment prior to transplantation
Amount £59,664 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2018
 
Description DESIGN AND PRODUCTION OF A COMMERCIAL PROTOTYPE OF A BREATH-ACETONE ANALYSER TO IMPROVE TREATMENT OF CHILDREN WITH LIFE-THREATENING DIABETIC KETOACIDOSIS
Amount £49,200 (GBP)
Organisation Durham University 
Sector Academic/University
Country United Kingdom
Start  
 
Description Development of a novel imaging method "Motor Unit Magnetic Resonance Imaging" (MUMRI) to investigate motor unit activity in ageing.
Amount £165,672 (GBP)
Funding ID NIHRBRC14 
Organisation National Institute for Health Research 
Department NIHR Newcastle Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Elucidating splicing factor function and retinal splicing programmes: developing new therapeutic strategies for splicing factor retinitis pigmentosa
Amount £1,319,396 (GBP)
Funding ID MR/T017503/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 09/2023
 
Description Examining efficacy of a novel bromodomain inhibitor AZD5153 in castrate resistant prostate cancer (MRC)
Amount £313,973 (GBP)
Funding ID MR/P009972/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Heriot Watt University EPSRC IAA
Amount £27,600 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Improved conjugate vaccines derived from bacterial immunomodulatory protein
Amount £238,883 (GBP)
Funding ID BB/N022165/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 07/2018
 
Description Investigating inflammation as a cause of pain and stiffness after knee replacement
Amount £15,000 (GBP)
Organisation The Royal College of Surgeons of Edinburgh 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2019 
 
Description MR imaging of motor unit dynamics as a non-invasive disease biomarker in spinal muscular atrophy
Amount £218,566 (GBP)
Funding ID 18GRO-PG36-0246 
Organisation Muscular Dystrophy UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2022
 
Description NWO Rubicon Fellowship - Motor unit assessment with magnetic resonance imaging. A new way to measure and understand the pathophysiology behind amyotrophic Iateral sclerosis
Amount £154,220 (GBP)
Organisation NWO Rubicon Fellowship 
Sector Private
Country Netherlands
Start 02/2020 
 
Description RNA helicase DDX3X regulates JAK-STAT signalling in acute lymphoblastic leukaemia
Amount £100,580 (GBP)
Organisation Children's Cancer and Leukaemia Group (CCLG) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description RfPB A systematic review of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes
Amount £144,908 (GBP)
Funding ID P21533 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 08/2017 
End 09/2018
 
Description Understanding the molecular and cellular complexity of human cornea through single cell analyses
Amount £458,770 (GBP)
Funding ID MR/S035826/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 12/2020
 
Description Validating SGK1 as a therapeutic target in advanced prostate cancer
Amount £132,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description nvestigating the role of alternative splicing in autosomal dominant retinitis pigmentosa using a PRPF31 patient specific induced pluripotent stem cell disease model
Amount £161,876 (GBP)
Funding ID GR595 
Organisation Retina UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 02/2021
 
Title GAS PHASE FLUORESCENCE ANALYSIS 
Description A method and apparatus for quantifying an analyte in a gas phase or liquid sample comprises: a pulsed or continuous, coherent or incoherent light source (10), a pair of reflective mirrors (13) located on the optical axis forming an optical cavity, and a cell (4) located between the mirrors (13), the cell (4) having a gas inlet (3) and a gas outlet (5); a fluorescence detector (17) located off the cavity axis and arranged to provide a first signal in response to fluorescence within the cavity; a photon detector (14) located axially external to the cavity and arranged to provide a second signal; wherein the apparatus including the axial photon detector (14) is configured to comprise a cavity enhanced absorption spectrometer; wherein apparatus including the off-axis photon detector is configured to comprise a cavity-enhanced laser-induced fluorescence (CELIF) spectrophotometer; means for supplying a pure sample or an analyte-containing sample to the cavity; a processor (9) adapted to receive a first signal to calibrate the apparatus and to receive a second signal to provide a measurement of the concentration of the analyte in the sample. 
IP Reference WO2017021424 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact N/A
 
Title Immunogenic compositions comprising Sbi protein and uses thereof 
Description pro-vaccine adjuvant SCOF ability to enhance the potency of immunisation of a candidate mycobacterium tuberculosis vaccine 
IP Reference GB1619965.5 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact builds on existing data to confirm that SCOF can induce improved/lasting immune cell memory. ability to function cross-species.