Newcastle Confidence in Concept 2015
Lead Research Organisation:
Newcastle University
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
People |
ORCID iD |
Publications
Attard V
(2020)
Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI.
in The bone & joint journal
Back C
(2017)
Utilising Staphylococcus aureus immune evasion protein Sbi as a novel vaccine conjugate
in Molecular Immunology
Bainbridge A
(2020)
IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway.
in Nucleic acids research
Bennett JL
(2019)
Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?
in Pediatric rheumatology online journal
Birkbeck MG
(2020)
Non-invasive imaging of single human motor units.
in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Birkbeck MG
(2021)
The role of novel motor unit magnetic resonance imaging to investigate motor unit activity in ageing skeletal muscle.
in Journal of cachexia, sarcopenia and muscle
Bojic S
(2018)
CD200 Expression Marks a Population of Quiescent Limbal Epithelial Stem Cells with Holoclone Forming Ability
in Stem Cells
Charman SJ
(2018)
A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care.
in ESC heart failure
Chen YC
(2017)
Thermal stability, storage and release of proteins with tailored fit in silica.
in Scientific reports
| Description | 3D hiPSC derived laminated retina model as a tool for toxicology studies |
| Amount | £1,000,000 (GBP) |
| Funding ID | NC/C016106/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2020 |
| Description | A new way to do motoneuron disease research |
| Amount | £1,011,726 (GBP) |
| Organisation | The William Leech Charity |
| Sector | Charity/Non Profit |
| Start | 04/2018 |
| End | 03/2021 |
| Description | A single cell sequencing approach to determine the heterogeneity, dynamics and cell fate decisions of retinal progenitor cells in vivo and in vitro |
| Amount | £917,013 (GBP) |
| Funding ID | BB/T004460/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2023 |
| Description | Adjunctive vagus nerve stimulation for improving gait in Parkinson's Disease (AdVaNSING-PD) |
| Amount | £128,048 (GBP) |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2019 |
| Description | Assessing SARS-CoV-2 entry, replication and prevention in a primary human conjunctival cell model and organ cultured cornea/conjunctiva. |
| Amount | £195,489 (GBP) |
| Funding ID | BB/V01126X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 02/2022 |
| Description | Assessing the feasibility of induced pluripotent stem cells to provide a disease model for Retinoblastoma |
| Amount | £169,982 (GBP) |
| Funding ID | 5095/5096 |
| Organisation | Fight for Sight |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 09/2021 |
| Description | CX3CR1 antagonist to prevent ischemia/reperfusion injury in patients undergoing primary PCI for STEMI |
| Amount | £1,700,010 (GBP) |
| Organisation | Kancera |
| Sector | Private |
| Country | Sweden |
| Start | 02/2021 |
| Description | Clinical Academic Research Partnership (CARP) award - Novel MRI Biomarkers in Neuromuscular Disease |
| Amount | £146,625 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| Description | Commercialisation of a Breath-Acetone Sensor |
| Amount | £50,000 (GBP) |
| Organisation | SETsquared Partnership |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Confidence in Concept 2016 - Cell surface marking of corneal epithelial stem cells: a powerful approach to stem cell enrichment prior to transplantation |
| Amount | £59,664 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2018 |
| Description | DESIGN AND PRODUCTION OF A COMMERCIAL PROTOTYPE OF A BREATH-ACETONE ANALYSER TO IMPROVE TREATMENT OF CHILDREN WITH LIFE-THREATENING DIABETIC KETOACIDOSIS |
| Amount | £49,200 (GBP) |
| Organisation | Durham University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Development of a novel imaging method "Motor Unit Magnetic Resonance Imaging" (MUMRI) to investigate motor unit activity in ageing. |
| Amount | £165,672 (GBP) |
| Funding ID | NIHRBRC14 |
| Organisation | National Institute for Health Research |
| Department | NIHR Newcastle Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2021 |
| Description | Elucidating splicing factor function and retinal splicing programmes: developing new therapeutic strategies for splicing factor retinitis pigmentosa |
| Amount | £1,319,396 (GBP) |
| Funding ID | MR/T017503/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 09/2023 |
| Description | Examining efficacy of a novel bromodomain inhibitor AZD5153 in castrate resistant prostate cancer (MRC) |
| Amount | £313,973 (GBP) |
| Funding ID | MR/P009972/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 01/2020 |
| Description | Heriot Watt University EPSRC IAA |
| Amount | £27,600 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Improved conjugate vaccines derived from bacterial immunomodulatory protein |
| Amount | £238,883 (GBP) |
| Funding ID | BB/N022165/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 07/2018 |
| Description | Investigating inflammation as a cause of pain and stiffness after knee replacement |
| Amount | £15,000 (GBP) |
| Organisation | The Royal College of Surgeons of Edinburgh |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2019 |
| Description | MR imaging of motor unit dynamics as a non-invasive disease biomarker in spinal muscular atrophy |
| Amount | £218,566 (GBP) |
| Funding ID | 18GRO-PG36-0246 |
| Organisation | Muscular Dystrophy UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2022 |
| Description | NWO Rubicon Fellowship - Motor unit assessment with magnetic resonance imaging. A new way to measure and understand the pathophysiology behind amyotrophic Iateral sclerosis |
| Amount | £154,220 (GBP) |
| Organisation | NWO Rubicon Fellowship |
| Sector | Private |
| Country | Netherlands |
| Start | 02/2020 |
| Description | RNA helicase DDX3X regulates JAK-STAT signalling in acute lymphoblastic leukaemia |
| Amount | £100,580 (GBP) |
| Organisation | Children's Cancer and Leukaemia Group (CCLG) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | RfPB A systematic review of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes |
| Amount | £144,908 (GBP) |
| Funding ID | P21533 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 09/2018 |
| Description | Understanding the molecular and cellular complexity of human cornea through single cell analyses |
| Amount | £458,770 (GBP) |
| Funding ID | MR/S035826/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 12/2020 |
| Description | Validating SGK1 as a therapeutic target in advanced prostate cancer |
| Amount | £132,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | nvestigating the role of alternative splicing in autosomal dominant retinitis pigmentosa using a PRPF31 patient specific induced pluripotent stem cell disease model |
| Amount | £161,876 (GBP) |
| Funding ID | GR595 |
| Organisation | Retina UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 02/2021 |
| Title | GAS PHASE FLUORESCENCE ANALYSIS |
| Description | A method and apparatus for quantifying an analyte in a gas phase or liquid sample comprises: a pulsed or continuous, coherent or incoherent light source (10), a pair of reflective mirrors (13) located on the optical axis forming an optical cavity, and a cell (4) located between the mirrors (13), the cell (4) having a gas inlet (3) and a gas outlet (5); a fluorescence detector (17) located off the cavity axis and arranged to provide a first signal in response to fluorescence within the cavity; a photon detector (14) located axially external to the cavity and arranged to provide a second signal; wherein the apparatus including the axial photon detector (14) is configured to comprise a cavity enhanced absorption spectrometer; wherein apparatus including the off-axis photon detector is configured to comprise a cavity-enhanced laser-induced fluorescence (CELIF) spectrophotometer; means for supplying a pure sample or an analyte-containing sample to the cavity; a processor (9) adapted to receive a first signal to calibrate the apparatus and to receive a second signal to provide a measurement of the concentration of the analyte in the sample. |
| IP Reference | WO2017021424 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | N/A |
| Title | Immunogenic compositions comprising Sbi protein and uses thereof |
| Description | pro-vaccine adjuvant SCOF ability to enhance the potency of immunisation of a candidate mycobacterium tuberculosis vaccine |
| IP Reference | GB1619965.5 |
| Protection | Patent application published |
| Year Protection Granted | 2016 |
| Licensed | No |
| Impact | builds on existing data to confirm that SCOF can induce improved/lasting immune cell memory. ability to function cross-species. |