Cambridge Confidence in Concepts: translating pathophysiological insights for patient benefit
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
| Patrick Maxwell (Principal Investigator) |
Publications
Thackray AM
(2021)
A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila.
in The Journal of biological chemistry
Swaddiwudhipong N
(2021)
Investigating the Electrical Properties of Different Cochlear Implants.
in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Ramakrishnan NK
(2021)
Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971.
in European journal of nuclear medicine and molecular imaging
Popescu DM
(2019)
Decoding human fetal liver haematopoiesis.
in Nature
Oedekoven C
(2021)
Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures
in Stem Cell Reports
Meijers A
(2020)
Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9
in Tuberculosis
Lyne AM
(2018)
A track of the clones: new developments in cellular barcoding.
in Experimental hematology
Lee-Six H
(2018)
Population dynamics of normal human blood inferred from somatic mutations.
in Nature
| Description | 4th year extension for Serena Belluschi's PhD Cambridge Cancer Centre fellowship |
| Amount | £24,521 (GBP) |
| Funding ID | RG81381 |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 09/2018 |
| End | 09/2019 |
| Description | 779822 BioMagMat - Functional magnetic materials for biomedical applications |
| Amount | € 149,997 (EUR) |
| Funding ID | 779822 BioMagMat |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2017 |
| End | 05/2019 |
| Description | A preclinical PET-CT scanner for advancing dementia research |
| Amount | £150,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 02/2019 |
| Description | ACF 25% protected time for clinical trainees for research |
| Amount | £60,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 05/2021 |
| Description | Adaptive Molecular Diagnostics |
| Amount | £750,858 (GBP) |
| Funding ID | 218453/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 11/2024 |
| Description | Amendment PhD studentship: Impact of cell & gene therapy on the function and molecular regulation of haematopoietic stem cells |
| Amount | £64,766 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 09/2018 |
| End | 09/2019 |
| Description | Bioassay of cervid prions in Drosophila |
| Amount | £476,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | CRUK small grant |
| Amount | £50,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 01/2018 |
| Description | Cambridge Enterprise Seed Funds: Pathfinder Grant |
| Amount | £20,000 (GBP) |
| Organisation | University of Cambridge |
| Department | Cambridge Enterprise |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2017 |
| Description | DEVELOPMENT OF A PERSONALISED RISK PREDICTION TOOL TO INFORM TREATMENT SELECTION AND IMPROVE OUTCOMES IN MEN WITH NEWLY DIAGNOSED PRIMARY NON-METASTATIC PROSTATE CANCER |
| Amount | £42,376 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2018 |
| Description | DEVELOPMENT OF A PERSONALISED RISK PREDICTION TOOL TO INFORM TREATMENT SELECTION AND IMPROVE OUTCOMES IN MEN WITH NEWLY DIAGNOSED PRIMARY NON-METASTATIC PROSTATE CANCER |
| Amount | £42,376 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2018 |
| Description | Detection of blood-borne prions |
| Amount | £1,280,000 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | |
| Description | EPSRC Project grant |
| Amount | £783,024 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| Description | Host-TB: Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis |
| Amount | € 2,160,926 (EUR) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 05/2019 |
| End | 05/2024 |
| Description | Improving Localisation, Diagnosis and Quantification in Clinical and Medical PET Imaging with Randomised |
| Amount | £1,013,321 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| Description | Improving outcomes of cochlear implants using an integrated engineering, basic science and clinical research team approach |
| Amount | £167,000 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 08/2021 |
| Description | NIH Programme Grant - Detection of blood-borne prions |
| Amount | £1,000,200 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | |
| Description | Platform for next generation of cochlear implants |
| Amount | £187,000 (GBP) |
| Organisation | William Demant Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | |
| Description | Quantitative Analysis of Clonality in Haematopoiesis - Concepts, methods and potential |
| Amount | £9,073 (GBP) |
| Funding ID | BB/R021465/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 10/2018 |
| Description | Rapid Multi-antigen COVID-19 Point-of-Care Antibody Test from a Pin-Prick Blood Sample |
| Amount | £256,000 (GBP) |
| Funding ID | EP/V043277/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 04/2022 |
| Description | Rapid bioassay of cervid prions in PrP transgenic Drosophila: addressing the threat to animal and human health from Chronic Wasting Disease |
| Amount | £475,660 (GBP) |
| Funding ID | BB/T00343X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2023 |
| Description | Serena Belluschi's PhD Cambridge Cancer Centre fellowship |
| Amount | £64,766 (GBP) |
| Funding ID | • RG91305 |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 09/2017 |
| End | 09/2021 |
| Description | The use of PrP transgenic Drosophila to replace and reduce mice in the bioassay of mammalian prions |
| Amount | £75,608 (GBP) |
| Funding ID | NC/R00093X/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 06/2019 |
| Description | Wellcome Trust Innovator Award - for further testing the diagnostic system |
| Amount | £750,858 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | cochlear implants |
| Amount | £62,099 (GBP) |
| Organisation | University of Cambridge |
| Department | Trinity College Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2021 |
| Description | funding for clinician-scientist |
| Amount | £210,000 (GBP) |
| Organisation | Oticon Medical |
| Sector | Private |
| Country | France |
| Start | |
| Title | A novel split mode TFBAR device for quantitative measurements of prostate specific antigen in a small sample of whole blood |
| Description | The project brought together research into biomarkers for prostate cancer with the novel FBAR sensing technology with a particular focus on demonstrating operation with whole blood samples for the first time. |
| Type Of Material | Biological samples |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | But important milestones are completed: 1 and 2 completed. 3 and 4 partially completed as problem with getting PSA isoform antibody, but it has been shown that measurement of total PSA can be performed in whole blood samples without significant preparation with both the sensitivity and selectivity required for clinical applications. This was the key proof of concept that was required |
| Description | Measuring electrical spread outside the cochlea |
| Organisation | Advanced Bionics Inc. (AB) |
| Department | Advanced Bionics UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have developed methods to measure electrical potentials in cadavers at sites distant to the cochlea |
| Collaborator Contribution | They have provided several fully functioning electrodes |
| Impact | ongoing |
| Start Year | 2019 |
| Company Name | Sorex Sensors |
| Description | Sorex Sensors develops very small sensors designed to detect small masses. |
| Year Established | 2017 |
| Impact | Sorex Sensors has now produced a stand-alone box of electronics which connects via USB to a computer and an associated app to drive the box. This allows the sensors to be driven without the need for an expensive Network Analyser and LabVIEW. The company has also transferred production of the sensor devices to a foundry. |
| Website | http://sorexsensors.com |
| Company Name | Spliceor Therapeutics |
| Description | Spliceor Therapeutics develops medical therapies, specialising in cancer treatments. |
| Year Established | 2020 |
| Impact | N/A |
| Company Name | Cambridge Medical Innovation Ltd |
| Description | |
| Year Established | 2020 |
| Impact | CMI Ltd has been awarded an Innovate UK grant to pilot the technology in NHS Scotland. An NIHR i4i grant application was submitted in December 2020 to cover development and pilot of an integrated platform to enable DigiVis and other digital tests to work within NHS clinician and patient workflows. Cambridge Enterprise has enabled Free of Charge use of DigiVis during the Covid crisis to support remote consultations at CUH and catch up vision screening by CCS. |
| Description | A novel split mode TFBAR device for quantitative measurements of prostate specific antigen in a small sample of whole blood |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Appearance on - BBC Look East - BBC Breakfast |
| Year(s) Of Engagement Activity | 2020 |
| Description | Abstract selected for short-talk at Single Cell Biology Conference (Wellcome Sanger Institute) virtual edition. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Abstract selected for short talk Virtual edition presented by Carys Johnson, PhD Student at the Wellcome Sanger Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Engaging Public Health for Development and Deployment of Adaptive Molecular Diagnostics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The test and strategy was presented to the WHO and it was very well received. They wanted speedy progress but that has been stalled due to absence of dedicated funds for the project since the closure of MRC-CiC award. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Great Ormond Street Hospital Academic Teaching - Activated PI3 kinase Delta Syndrome (APDS): from genetics to therapy and beyond |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited Speaker at MRC Centre for Regenerative Medicine, Edinburgh |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Requests for further information |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited speaker at Columbia, Genetics and Development Seminar Series, New York |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Columbia, Genetics and Development Seminar Series, New York, United States. (Virtual seminar) Requests for further information. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker at IBSC virtual seminar, University of Exeter |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at IBSC virtual seminar, University of Exeter - Requests for further information |
| Year(s) Of Engagement Activity | 2012,2021 |
| Description | Virtual reality can spot navigation problems in early Alzheimer's disease |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Virtual reality (VR) can identify early Alzheimer's disease more accurately than 'gold standard' cognitive tests currently in use, suggests new research from the University of Cambridge. We've wanted to do this for years, but it's only now that virtual reality technology has evolved to the point that we can readily undertake this research in patients |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.cam.ac.uk/research/news/virtual-reality-can-spot-navigation-problems-in-early-alzheimers... |