UK Biobank (core renewal)
Lead Research Organisation:
UK Biobank
Department Name: UNLISTED
Abstract
UK Biobank is supported by The Wellcome Trust, The National Institute of Health Research, The Medical Research Council, The British Heart Foundation and Cancer Research UK. The figures presented on this record represent the Medical Research Council funding contribution only with some additional UKRI Infrastructure funds in addition.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
Technical Summary
The UK Biobank resource has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. There are now sufficient numbers of incident cases of the commoner conditions to support extensive and powerful research into their determinants.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
Organisations
People |
ORCID iD |
Rory Collins (Principal Investigator) |
Publications
Oksuz I
(2020)
Deep Learning-Based Detection and Correction of Cardiac MR Motion Artefacts During Reconstruction for High-Quality Segmentation.
in IEEE transactions on medical imaging
Olafsdottir T
(2020)
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.
in Communications biology
Olafsdottir TA
(2020)
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.
in Nature communications
Olinger E
(2022)
An intermediate-effect size variant in UMOD confers risk for chronic kidney disease.
in Proceedings of the National Academy of Sciences of the United States of America
Olivo G
(2019)
Low neuroticism and cognitive performance are differently associated to overweight and obesity: A cross-sectional and longitudinal UK Biobank study.
in Psychoneuroendocrinology
Olvera-Barrios A
(2022)
Foveal Curvature and Its Associations in UK Biobank Participants.
in Investigative ophthalmology & visual science
Omiyale W
(2020)
Body size, body composition and endometrial cancer risk among postmenopausal women in UK Biobank.
in International journal of cancer
Ong JS
(2018)
Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study.
in Human molecular genetics
Ong JS
(2018)
Height and overall cancer risk and mortality: evidence from a Mendelian randomisation study on 310,000 UK Biobank participants.
in British journal of cancer
Ong JS
(2019)
Association between coffee consumption and overall risk of being diagnosed with or dying from cancer among >300 000 UK Biobank participants in a large-scale Mendelian randomization study.
in International journal of epidemiology
Ong JS
(2018)
Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization.
in Scientific reports
Orliac EJ
(2022)
Improving GWAS discovery and genomic prediction accuracy in biobank data.
in Proceedings of the National Academy of Sciences of the United States of America
Ortega N
(2022)
Hippocampal volume mediates the association between depression and cognitive function differently by sex
in Alzheimer's & Dementia
Ortiz A
(2022)
Sex-specific associations between lifetime diagnosis of bipolar disorder and cardiovascular disease: A cross-sectional analysis of 257,673 participants from the UK Biobank.
in Journal of affective disorders
Ostendorf BN
(2022)
Common human genetic variants of APOE impact murine COVID-19 mortality.
in Nature
Oster J
(2020)
Identification of patients with atrial fibrillation: a big data exploratory analysis of the UK Biobank.
in Physiological measurement
Ou Y
(2022)
Causal effects of serum sex hormone binding protein levels on the risk of amyotrophic lateral sclerosis: a mendelian randomization study
in Annals of Translational Medicine
Owen D
(2018)
Effects of pathogenic CNVs on physical traits in participants of the UK Biobank.
in BMC genomics
Paccou J
(2018)
Prior fragility fracture and risk of incident ischaemic cardiovascular events: results from UK Biobank.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Pack A
(2022)
Sleep and its Disorders - Translational Medicine
Page ML
(2022)
The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores.
in Communications biology
Paik H
(2022)
Analysis of the docking property of host variants of hACE2 for SARS-CoV-2 in a large cohort.
in PLoS computational biology
Paik H
(2022)
Identification of a pleiotropic effect of ADIPOQ on cardiac dysfunction and Alzheimer's disease based on genetic evidence and health care records.
in Translational psychiatry
Pain O
(2022)
A tool for translating polygenic scores onto the absolute scale using summary statistics.
in European journal of human genetics : EJHG
Pain O
(2021)
Evaluation of polygenic prediction methodology within a reference-standardized framework.
in PLoS genetics
Pairo-Castineira E
(2022)
GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19
Palamara PF
(2018)
High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability.
in Nature genetics
Palmer MR
(2021)
Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.
in Genetic epidemiology
Palpatzis E
(2022)
Longitudinal association of apolipoprotein E and sleep with incident dementia.
in Alzheimer's & dementia : the journal of the Alzheimer's Association
Paludan-Muller C
(2022)
Loss-of-function variants in founder population highlight atrial myopathy as susceptibility to atrial fibrillation
in European Heart Journal
Pan C
(2022)
The Comprehensive Effect of Socioeconomic Deprivation on Smoking Behavior: an Observational and Genome-Wide by Environment Interaction Analyses in UK Biobank
in International Journal of Mental Health and Addiction
Pan DZ
(2021)
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.
in Genome medicine
Pan F
(2019)
Association between musculoskeletal pain at multiple sites and objectively measured physical activity and work capacity: Results from UK Biobank study.
in Journal of science and medicine in sport
Pan GQ
(2022)
The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study.
in European journal of medical research
Pan W
(2022)
Sex-Specific Associations of Dietary Iron Intake with Brain Iron Deposition on Imaging and Incident Dementia: A Prospective Cohort Study.
in The journal of nutrition, health & aging
Pan X
(2022)
Exploring the genetic correlation between obesity-related traits and regional brain volumes: Evidence from UK Biobank cohort.
in NeuroImage. Clinical
Pang S
(2023)
Genetic and modifiable risk factors combine multiplicatively in common disease.
in Clinical research in cardiology : official journal of the German Cardiac Society
Pang Y
(2020)
Observational and Genetic Associations of Body Mass Index and Hepatobiliary Diseases in a Relatively Lean Chinese Population
in JAMA Network Open
Panter J
(2018)
Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality.
in Heart (British Cardiac Society)
Papadimitriou N
(2023)
Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.
in BMC medicine
Papadopoulou A
(2022)
Prediction of atrial fibrillation and stroke using machine learning models in UK Biobank
Papadopoulou A
(2021)
COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases.
in PloS one
Papageorgiou M
(2019)
Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women.
in Journal of cachexia, sarcopenia and muscle
Description | Impact of clinically silent atrial fibrillation on cerebrovascular disease and cognitive decline in the UK Biobank Imaging Cohort |
Amount | £2,474,260 (GBP) |
Funding ID | RG/18/6/33576 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2019 |
End | 06/2024 |
Description | UK Biobank - The Repeat Imaging Project |
Amount | £2,500,000 (GBP) |
Funding ID | R39738/CN039 |
Organisation | MRC Dementias Platform UK |
Sector | Academic/University |
Country | United Kingdom |
Start | 04/2019 |
End | 01/2023 |
Description | UK Biobank - Whole genome sequencing of 50,000 UKB participants |
Amount | £30,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2020 |
Description | UK Biobank- Expansion of the UKB imaging to a 4th centre and repeat imaging assessment of 10,000 participants |
Amount | £8,500,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 12/2022 |
Description | UK Biobank Scientific Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The UK Biobank Scientific Symposium included presentations about the successes and future plans of the UK Biobank. It took place on 21 June 2018 in London |
Year(s) Of Engagement Activity | 2018 |
Description | UK Biobank participant imaging event |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UK Biobank for participants of the imaging work |
Year(s) Of Engagement Activity | 2021 |
Description | UKBiobank participant events - 2014 - 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UKB Biobank participants regularly attend events aimed at informing them about the work being undertaken with their data. Usually, the events last a few hours and include an overview from the chief scientist and two talks from scientists that have used UKB data. From 2014 - 2020 over 4,000 participants have taken part in events in Edinburgh (4), Manchester (4), Nottingham, Leeds, Cardiff (2), Newcastle (5), Glasgow (2), Bristol (2) and Reading(4). They are often over-subscribed and participants leave these events wishing to seek more information and support he programme in new ways (EG in imaging, genome sequencing) |
Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018,2019 |
URL | http://www.ukbiobank.ac.uk |