UK Biobank (core renewal)
Lead Research Organisation:
UK Biobank
Department Name: UNLISTED
Abstract
UK Biobank is supported by The Wellcome Trust, The National Institute of Health Research, The Medical Research Council, The British Heart Foundation and Cancer Research UK. The figures presented on this record represent the Medical Research Council funding contribution only with some additional UKRI Infrastructure funds in addition.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
Technical Summary
The UK Biobank resource has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. There are now sufficient numbers of incident cases of the commoner conditions to support extensive and powerful research into their determinants.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
Organisations
People |
ORCID iD |
Rory Collins (Principal Investigator) |
Publications
Leming M
(2021)
Deep learning for sex classification in resting-state and task functional brain networks from the UK Biobank.
in NeuroImage
Chormai P
(2022)
Machine learning of large-scale multimodal brain imaging data reveals neural correlates of hand preference.
in NeuroImage
Cherkaoui H
(2021)
Multivariate semi-blind deconvolution of fMRI time series.
in NeuroImage
Rolls ET
(2022)
Risk-taking in humans and the medial orbitofrontal cortex reward system.
in NeuroImage
Fraza CJ
(2021)
Warped Bayesian linear regression for normative modelling of big data.
in NeuroImage
Davenport S
(2020)
Selective peak inference: Unbiased estimation of raw and standardized effect size at local maxima.
in NeuroImage
Williams CM
(2022)
Comparing brain asymmetries independently of brain size.
in NeuroImage
Sundaresan V
(2019)
Modelling the distribution of white matter hyperintensities due to ageing on MRI images using Bayesian inference.
in NeuroImage
Shadrin AA
(2021)
Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.
in NeuroImage
Bowring A
(2021)
Confidence Sets for Cohen's d effect size images.
in NeuroImage
Loughnan RJ
(2022)
Generalization of cortical MOSTest genome-wide associations within and across samples.
in NeuroImage
Warrington S
(2020)
XTRACT - Standardised protocols for automated tractography in the human and macaque brain.
in NeuroImage
Rafipoor H
(2022)
Identifying microstructural changes in diffusion MRI; How to circumvent parameter degeneracy.
in NeuroImage
Mekki Y
(2022)
The genetic architecture of language functional connectivity.
in NeuroImage
Buchanan CR
(2020)
The effect of network thresholding and weighting on structural brain networks in the UK Biobank.
in NeuroImage
Lemaitre H
(2023)
Genetic variations within human gained enhancer elements affect human brain sulcal morphology
in NeuroImage
Farahibozorg SR
(2021)
Hierarchical modelling of functional brain networks in population and individuals from big fMRI data.
in NeuroImage
Jiao Z
(2022)
A model-based approach to assess reproducibility for large-scale high-throughput MRI-based studies
in NeuroImage
Griffanti L
(2022)
Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic.
in NeuroImage. Clinical
Pan X
(2022)
Exploring the genetic correlation between obesity-related traits and regional brain volumes: Evidence from UK Biobank cohort.
in NeuroImage. Clinical
Schindler LS
(2022)
Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women.
in NeuroImage. Clinical
Veldsman M
(2020)
Spatial distribution and cognitive impact of cerebrovascular risk-related white matter hyperintensities.
in NeuroImage. Clinical
Topiwala A
(2022)
Alcohol consumption and MRI markers of brain structure and function: Cohort study of 25,378 UK Biobank participants.
in NeuroImage. Clinical
Zhang B
(2023)
Age-level bias correction in brain age prediction
in NeuroImage: Clinical
Lu H
(2021)
Relationships between accelerometer-measured and multiple sclerosis: a 2-sample Mendelian randomization study.
in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Hamer M
(2019)
Association of body mass index and waist-to-hip ratio with brain structure: UK Biobank study.
in Neurology
Guo Y
(2021)
Phenotypic and Genotypic Associations Between Migraine and Lipoprotein Subfractions.
in Neurology
Hooshmand B
(2022)
Diabetes and Dementia: Spotlight on Multidomain Lifestyle Strategies.
in Neurology
Whalley L
(2022)
The Cognitive Costs of Social Isolation.
in Neurology
Acosta JN
(2023)
Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors.
in Neurology
Furlong MA
(2022)
Association of Air Pollution and Physical Activity With Brain Volumes.
in Neurology
Peters SAE
(2020)
Sex differences in the association between major risk factors and the risk of stroke in the UK Biobank cohort study.
in Neurology
Li H
(2022)
Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort Study.
in Neurology
Rutten JW
(2020)
Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance.
in Neurology
Shen C
(2022)
Associations of Social Isolation and Loneliness With Later Dementia.
in Neurology
Taylor-Bateman V
(2022)
Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study.
in Neurology
Rannikmäe K
(2020)
Accuracy of identifying incident stroke cases from linked health care data in UK Biobank.
in Neurology
Bowman K
(2019)
Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.
in Neurology
Description | Impact of clinically silent atrial fibrillation on cerebrovascular disease and cognitive decline in the UK Biobank Imaging Cohort |
Amount | £2,474,260 (GBP) |
Funding ID | RG/18/6/33576 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2019 |
End | 06/2024 |
Description | UK Biobank - The Repeat Imaging Project |
Amount | £2,500,000 (GBP) |
Funding ID | R39738/CN039 |
Organisation | MRC Dementias Platform UK |
Sector | Academic/University |
Country | United Kingdom |
Start | 04/2019 |
End | 01/2023 |
Description | UK Biobank - Whole genome sequencing of 50,000 UKB participants |
Amount | £30,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2020 |
Description | UK Biobank- Expansion of the UKB imaging to a 4th centre and repeat imaging assessment of 10,000 participants |
Amount | £8,500,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 12/2022 |
Description | UK Biobank Scientific Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The UK Biobank Scientific Symposium included presentations about the successes and future plans of the UK Biobank. It took place on 21 June 2018 in London |
Year(s) Of Engagement Activity | 2018 |
Description | UK Biobank participant imaging event |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UK Biobank for participants of the imaging work |
Year(s) Of Engagement Activity | 2021 |
Description | UKBiobank participant events - 2014 - 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UKB Biobank participants regularly attend events aimed at informing them about the work being undertaken with their data. Usually, the events last a few hours and include an overview from the chief scientist and two talks from scientists that have used UKB data. From 2014 - 2020 over 4,000 participants have taken part in events in Edinburgh (4), Manchester (4), Nottingham, Leeds, Cardiff (2), Newcastle (5), Glasgow (2), Bristol (2) and Reading(4). They are often over-subscribed and participants leave these events wishing to seek more information and support he programme in new ways (EG in imaging, genome sequencing) |
Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018,2019 |
URL | http://www.ukbiobank.ac.uk |